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Explainable AI in Medical Informatics and Decision Support

Guest Editor: Professor Andreas Holzinger

Based on a successful workshop on explainable AI during the Cross Domain for Machine Learning and Knowledge Extraction (CD-MAKE) 2018 conference, BMC Medical Informatics and Decision Making is delighted to showcase this special collection of papers. The grand goal of future explainable AI is to make results understandable and transparent  and to answer questions of how and why a result was achieved. In fact: “Can we explain how and why a specific result was achieved by an algorithm?”

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  1. This study was designed for the research and development (R&D) and application of a storage inflow and outflow management system enabling departments to perform efficient, scientific, and information-based con...

    Authors: Jiang Luo, Yan Wang, Yongze Zhang, Xiaofang Yan, Xiaoting Huang and Fengying Zhao
    Citation: BMC Medical Informatics and Decision Making 2022 22:9
  2. Although deep neural networks (DNNs) are showing state of the art performance in clinical gait analysis, they are considered to be black-box algorithms. In other words, there is a lack of direct understanding ...

    Authors: Benjamin Filtjens, Pieter Ginis, Alice Nieuwboer, Muhammad Raheel Afzal, Joke Spildooren, Bart Vanrumste and Peter Slaets
    Citation: BMC Medical Informatics and Decision Making 2021 21:341
  3. Vietnam is undergoing a fast-aging process that poses potential critical issues for older people and central among those is demand for healthcare utilization. However, healthcare utilization, here measured as ...

    Authors: Duc Dung Le, Roberto Leon Gonzalez and Joseph Upile Matola
    Citation: BMC Medical Informatics and Decision Making 2021 21:265
  4. Adverse drug reactions (ADRs) are statistically characterized within randomized clinical trials and postmarketing pharmacovigilance, but their molecular mechanism remains unknown in most cases. This is true ev...

    Authors: Emmanuel Bresso, Pierre Monnin, Cédric Bousquet, François-Elie Calvier, Ndeye-Coumba Ndiaye, Nadine Petitpain, Malika Smaïl-Tabbone and Adrien Coulet
    Citation: BMC Medical Informatics and Decision Making 2021 21:171
  5. Heterogeneity among patients’ responses to treatment is prevalent in psychiatric disorders. Personalized medicine approaches—which involve parsing patients into subgroups better indicated for a particular trea...

    Authors: Monika S. Mellem, Matt Kollada, Jane Tiller and Thomas Lauritzen
    Citation: BMC Medical Informatics and Decision Making 2021 21:162
  6. The motion capture has been used as the usual method for measuring movement parameters of human, and most of the measuring data are obtained by partial manual process based on commercial software. An automatic...

    Authors: Jian-ping Wang, Shi-hua Wang, Yan-qing Wang, Hai Hu, Jin-wei Yu, Xuan Zhao, Jin-lai Liu, Xu Chen and Yu Li
    Citation: BMC Medical Informatics and Decision Making 2021 21:121
  7. Fatigue is a kind of non-specific symptom, which occurs widely in sub-health and various diseases. It is closely related to people's physical and mental health. Due to the lack of objective diagnostic criteria...

    Authors: Yulin Shi, Xiaojuan Hu, Ji Cui, Longtao Cui, Jingbin Huang, Xuxiang Ma, Tao Jiang, Xinghua Yao, Fang Lan, Jun Li, Zijuan Bi, Jiacai Li, Yu Wang, Hongyuan Fu, Jue Wang, Yanting Lin…
    Citation: BMC Medical Informatics and Decision Making 2021 21:72
  8. Health Information System is the key to making evidence-based decisions. Ethiopia has been implementing the Health Management Information System (HMIS) since 2008 to collect routine health data and revised it ...

    Authors: Moges Asressie Chanyalew, Mezgebu Yitayal, Asmamaw Atnafu and Binyam Tilahun
    Citation: BMC Medical Informatics and Decision Making 2021 21:28
  9. Early alarm of hypoglycemia, detection of asymptomatic hypoglycemia, and effective control of blood glucose fluctuation make a great contribution to diabetic treatment. In this study, we designed a multi-level...

    Authors: Xia Yu, Ning Ma, Tao Yang, Yawen Zhang, Qing Miao, Junjun Tao, Hongru Li, Yiming Li and Yehong Yang
    Citation: BMC Medical Informatics and Decision Making 2021 21:22
  10. Explainability is one of the most heavily debated topics when it comes to the application of artificial intelligence (AI) in healthcare. Even though AI-driven systems have been shown to outperform humans in ce...

    Authors: Julia Amann, Alessandro Blasimme, Effy Vayena, Dietmar Frey and Vince I. Madai
    Citation: BMC Medical Informatics and Decision Making 2020 20:310
  11. Syndrome differentiation aims at dividing patients into several types according to their clinical symptoms and signs, which is essential for traditional Chinese medicine (TCM). Several previous works were devo...

    Authors: Huaxin Pang, Shikui Wei, Yufeng Zhao, Liyun He, Jian Wang, Baoyan Liu and Yao Zhao
    Citation: BMC Medical Informatics and Decision Making 2020 20:264
  12. Emergency room reports pose specific challenges to natural language processing techniques. In this setting, violence episodes on women, elderly and children are often under-reported. Categorizing textual descr...

    Authors: Enrico Mensa, Davide Colla, Marco Dalmasso, Marco Giustini, Carlo Mamo, Alessio Pitidis and Daniele P. Radicioni
    Citation: BMC Medical Informatics and Decision Making 2020 20:263
  13. A decade ago, the advancements in the microbiome data sequencing techniques initiated the development of research of the microbiome and its relationship with the host organism. The development of sophisticated...

    Authors: Jasminka Hasic Telalovic and Azra Music
    Citation: BMC Medical Informatics and Decision Making 2020 20:262
  14. There is an increasing interest in clinical prediction tools that can achieve high prediction accuracy and provide explanations of the factors leading to increased risk of adverse outcomes. However, approaches...

    Authors: Amie J. Barda, Christopher M. Horvat and Harry Hochheiser
    Citation: BMC Medical Informatics and Decision Making 2020 20:257
  15. We focus on the importance of interpreting the quality of the labeling used as the input of predictive models to understand the reliability of their output in support of human decision-making, especially in cr...

    Authors: Federico Cabitza, Andrea Campagner and Luca Maria Sconfienza
    Citation: BMC Medical Informatics and Decision Making 2020 20:219
  16. One of the most challenging tasks for bladder cancer diagnosis is to histologically differentiate two early stages, non-invasive Ta and superficially invasive T1, the latter of which is associated with a signi...

    Authors: Peng-Nien Yin, Kishan KC, Shishi Wei, Qi Yu, Rui Li, Anne R. Haake, Hiroshi Miyamoto and Feng Cui
    Citation: BMC Medical Informatics and Decision Making 2020 20:162
  17. Infectious diseases that can cause epidemics, such as COVID-19, SARS-CoV, and MERS-CoV, constitute a major social issue, with healthcare providers fearing secondary, tertiary, and even quaternary infections. T...

    Authors: Dong-won Kim, Jin-young Choi and Keun-hee Han
    Citation: BMC Medical Informatics and Decision Making 2020 20:106
  18. In this study, we focus on building a fine-grained entity annotation corpus with the corresponding annotation guideline of traditional Chinese medicine (TCM) clinical records. Our aim is to provide a basis for...

    Authors: Tingting Zhang, Yaqiang Wang, Xiaofeng Wang, Yafei Yang and Ying Ye
    Citation: BMC Medical Informatics and Decision Making 2020 20:64
  19. A variant of unknown significance (VUS) is a variant form of a gene that has been identified through genetic testing, but whose significance to the organism function is not known. An actual challenge in precis...

    Authors: Priscilla Machado do Nascimento, Inácio Gomes Medeiros, Raul Maia Falcão, Beatriz Stransky and Jorge Estefano Santana de Souza
    Citation: BMC Medical Informatics and Decision Making 2020 20:52
  20. The penetration level of mobile technology has grown exponentially and is part of our lifestyle, at all levels. The use of the smartphone has opened up a new horizon of possibilities in the treatment of health...

    Authors: A. Hernández-Reyes, G. Molina-Recio, R. Molina-Luque, M. Romero-Saldaña, F. Cámara-Martos and R. Moreno-Rojas
    Citation: BMC Medical Informatics and Decision Making 2020 20:40
  21. Cloud storage facilities (CSF) has become popular among the internet users. There is limited data on CSF usage among university students in low middle-income countries including Sri Lanka. In this study we pre...

    Authors: Samankumara Hettige, Eshani Dasanayaka and Dileepa Senajith Ediriweera
    Citation: BMC Medical Informatics and Decision Making 2020 20:10
  22. In classification and diagnostic testing, the receiver-operator characteristic (ROC) plot and the area under the ROC curve (AUC) describe how an adjustable threshold causes changes in two types of error: false...

    Authors: André M. Carrington, Paul W. Fieguth, Hammad Qazi, Andreas Holzinger, Helen H. Chen, Franz Mayr and Douglas G. Manuel
    Citation: BMC Medical Informatics and Decision Making 2020 20:4
  23. Fetal heart rate (FHR) monitoring is a screening tool used by obstetricians to evaluate the fetal state. Because of the complexity and non-linearity, a visual interpretation of FHR signals using common guideli...

    Authors: Zhidong Zhao, Yanjun Deng, Yang Zhang, Yefei Zhang, Xiaohong Zhang and Lihuan Shao
    Citation: BMC Medical Informatics and Decision Making 2019 19:286
  24. Predictive modeling with longitudinal electronic health record (EHR) data offers great promise for accelerating personalized medicine and better informs clinical decision-making. Recently, deep learning models...

    Authors: Rawan AlSaad, Qutaibah Malluhi, Ibrahim Janahi and Sabri Boughorbel
    Citation: BMC Medical Informatics and Decision Making 2019 19:214