Tumor talks: exosomes at center stage
Lead guest editor: Dr Tse-Hua Tan
Tumor-derived exosomes emerge as critical mediators in tumorigenesis and malignant tumor progression through reprograming and communicating with the tumor microenvironments in nearby and/or distant organs. The nature of tumor-derived exosomes, including versatile selectivity of dynamic biological contents, abundant existence in blood, specific targeting and uptake by cells, are regarded as promising diagnostic/prognostic biomarkers, therapeutic targets, and drug delivery systems. At present, numerous studies have shed light on the basis of exosome biology and pave the way for clinical applications of tumor-derived exosomes. This special issue is dedicated to review current and future directions of tumor exosomal research and its potential applications, which build the fundamentals for precision medicine of cancer management.