Sleep disorders affect billions of people worldwide, including children, adults, and elderly populations from both sexes. Sleep disorders entail problems with the quality, timing, and amount of sleep, which result in daytime distress and impairment in functioning, as well as the occurrence and severity of many morbidities. Evidence from clinical and mechanistic studies demonstrated the association of sleep disorders with metabolic, cardiovascular and cognitive disorders, and also with tumor aggressiveness and poor prognosis in cancer.
Mounting evidence suggests a fundamental role of epigenetic regulation in the pathophysiology of sleep disorders. This has opened a new research field for understanding the disease and its associated morbidities, aiming for new opportunities for therapeutic and diagnosis developments.
In this Collection, we are focusing on the latest advances on the understanding of epigenetic mechanisms in sleep disorders. In addition, we welcome submissions of clinical studies and methodological developments focused on the value of epigenetic variations for detecting, monitoring and predicting the outcomes of sleep disorders.