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Epigenetics and rheumatic diseases

Nan Shen

  1. Review

    microRNA-mediated regulation of innate immune response in rheumatic diseases

    miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the...

    Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen and Yihong Yao

    Arthritis Research & Therapy 2013 15:210

    Published on: 9 April 2013

  2. Review

    Dissecting complex epigenetic alterations in human lupus

    Systemic lupus erythematosus is a chronic relapsing autoimmune disease that primarilyafflicts women, and both a genetic predisposition and appropriate environmentalexposures are required for lupus to develop a...

    Dipak R Patel and Bruce C Richardson

    Arthritis Research & Therapy 2013 15:201

    Published on: 29 January 2013

  3. Review

    MicroRNA control in the development of systemic autoimmunity

    Mammalian immune responses are intended to eradicate microbial pathogens and thus protect individuals from the harmful effects of such infections. However, unresolved inflammation can be devastating to the hos...

    Ruozhen Hu and Ryan M O'Connell

    Arthritis Research & Therapy 2013 15:202

    Published on: 25 January 2013

  4. Review

    Epigenetic contributions in the development of rheumatoid arthritis

    Rheumatoid arthritis (RA) is an autoimmune disease, characterized by chronic inflammation of the joints with severe pain and swelling, joint damage and disability, which leads to joint destruction and loss of ...

    Kerstin Klein, Caroline Ospelt and Steffen Gay

    Arthritis Research & Therapy 2012 14:227

    Published on: 9 November 2012