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Enterovirus 71

Edited by Prof Ben Berkhout

Enterovirus 71 (EV71) was first isolated and characterized from cases of neurological disease in California in 1969. It spread then to Europe with outbreaks in Bulgaria (1975) and Hungary (1978). It has since spread to various countries in Asia where it has been responsible for several serious outbreaks. EV71 is notable as one of the major causative agents for hand, foot and mouth disease (HFMD), and is sometimes associated with severe central nervous system diseases.

Much remains to be learned about the molecular mechanisms of EV71 replication and the host immune response. This special issue, published in Journal of Biomedical Science, presents reviews and primary research papers on EV71 that cover several topics: a clinical guideline on management of children with HFMD, epidemiology of EV71 in Thailand, the cell and tissue tropism and the regulation of gene expression, and finally animal models for EV71 and the developments of antiviral drugs.

  1. Research

    Mutations in the non-structural protein region contribute to intra-genotypic evolution of enterovirus 71

    Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbre...

    Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su and Jen-Ren Wang

    Journal of Biomedical Science 2014 21:33

    Published on: 26 April 2014

  2. Research

    Epidemiology and seroepidemiology of human enterovirus 71 among Thai populations

    Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Understanding of the etiologi...

    Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang and Yong Poovorawan

    Journal of Biomedical Science 2014 21:16

    Published on: 18 February 2014

  3. Review

    Recent developments in antiviral agents against enterovirus 71 infection

    Enterovirus 71 (EV-71) is the main etiological agent of hand, foot and mouth disease (HFMD). Recent EV-71 outbreaks in Asia-Pacific were not limited to mild HFMD, but were associated with severe neurological c...

    Chee Wah Tan, Jeffrey Kam Fatt Lai, I-Ching Sam and Yoke Fun Chan

    Journal of Biomedical Science 2014 21:14

    Published on: 12 February 2014