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Enterovirus 71

Edited by Prof Ben Berkhout

Enterovirus 71 (EV71) was first isolated and characterized from cases of neurological disease in California in 1969. It spread then to Europe with outbreaks in Bulgaria (1975) and Hungary (1978). It has since spread to various countries in Asia where it has been responsible for several serious outbreaks. EV71 is notable as one of the major causative agents for hand, foot and mouth disease (HFMD), and is sometimes associated with severe central nervous system diseases.

Much remains to be learned about the molecular mechanisms of EV71 replication and the host immune response. This special issue, published in Journal of Biomedical Science, presents reviews and primary research papers on EV71 that cover several topics: a clinical guideline on management of children with HFMD, epidemiology of EV71 in Thailand, the cell and tissue tropism and the regulation of gene expression, and finally animal models for EV71 and the developments of antiviral drugs.

  1. We previously reported that Enterovirus 71 (EV71) infection activates autophagy, which promotes viral replication both in vitro and in vivo. In the present study we further investigated whether EV71 infection of ...

    Authors: Ying-Ray Lee, Po-Shun Wang, Jen-Ren Wang and Hsiao-Sheng Liu
    Citation: Journal of Biomedical Science 2014 21:80
  2. Clinical manifestations of enterovirus 71 (EV71) range from herpangina, hand-foot-and-mouth disease (HFMD), to severe neurological complications. Unlike the situation of switching genotypes seen in EV71 outbre...

    Authors: Sheng-Wen Huang, Hui-Li Cheng, Hsin-Yi Hsieh, Chia-Lun Chang, Huey-Pin Tsai, Pin-Hwa Kuo, Shih-Min Wang, Ching-Chuan Liu, Ih-Jen Su and Jen-Ren Wang
    Citation: Journal of Biomedical Science 2014 21:33
  3. Human enterovirus 71 (EV71) is an important pathogen caused large outbreaks in Asian-Pacific region with severe neurological complications and may lead to death in young children. Understanding of the etiologi...

    Authors: Piyada Linsuwanon, Jiratchaya Puenpa, Sheng-Wen Huang, Ya-Fang Wang, John Mauleekoonphairoj, Jen-Ren Wang and Yong Poovorawan
    Citation: Journal of Biomedical Science 2014 21:16