Skip to main content

Kinases, adaptor proteins, and actin cytoskeleton rearrangements in EMT and cancer

New Content Item

Edited by
Leszek Kotula, SUNY Upstate Medical University, USA
Patrycja Dubielecka-Szczerba, Brown University, USA

Cell Communications and Signaling invites you to submit to our new thematic series: Kinases, adaptor proteins, and actin cytoskeleton rearrangements in EMT and cancer.

Epithelial Mesenchymal Transition (EMT) is a complex molecular and cellular process defined by genetic and phenotypic changes in epithelial cells during embryonic development, tissue repair and cancer. EMT is characterized by changes in gene expression and epigenetic programs that profoundly change cellular phenotype and ultimately promote loss of cell-cell adhesion and gain in cell migratory activity. EMT appears to be a strong requisite not only for cancer development but also for metastatic dispersion of primary tumor cells. Comprehensive insight in EMT regulation will not only expand our understanding of tumor development and metastatic processes but it may also inform optimized diagnostics and therapeutic strategies.

Historically, the literature reviewed the role of transcriptional and epigenetic factors that regulate EMT. Here, in this special issue Cell Communication and Signaling, we focus on the molecular and mechanistic links between kinases, adaptor proteins, and actin cytoskeleton as critical components and executors of the EMT regulatory machinery. The EMT transcriptional and epigenetic programs ultimately govern phenotypic changes through actin cytoskeleton rearrangements orchestrated by activation of specific kinases such as SRC or ABL family kinases, or Focal Adhesion Kinase. These signals are then relayed to actin cytoskeleton by adaptor proteins such as ABI1, CRK, EPS8, and other important modulators of cell migration. 

Through this review series we hope to shed some more light on mechanistic links between genetic, epigenetic, enzymatic, spatial-signalling regulatory adaptor proteins and actin exoskeleton and their role in execution of phenotypic changes leading to EMT and cancer development and metastasis. We welcome the submission of additional manuscripts to this series. 

Submission deadline: December 31, 2021 (new)
Submit your manuscript here.

  1. Diabetic nephropathy (DN) involves various structural and functional changes because of chronic glycemic assault and kidney failure. Proteinuria is an early clinical manifestation of DN, but the associated pat...

    Authors: Lingfei Li, Yanhai Feng, Junhui Zhang, Qiong Zhang, Jun Ren, Cheng Sun, Shujing Li, Xia Lei, Gaoxing Luo, Jiongyu Hu and Yuesheng Huang
    Citation: Cell Communication and Signaling 2022 20:115
  2. The tumor microenvironment consists of stromal cells, extracellular matrix, and physicochemical properties (e.g., oxygenation, acidification). An important element of the tumor niche are cancer-associated fibr...

    Authors: Justyna Mazurkiewicz, Aleksandra Simiczyjew, Ewelina Dratkiewicz, Katarzyna Pietraszek-Gremplewicz, Michał Majkowski, Magdalena Kot, Marcin Ziętek, Rafał Matkowski and Dorota Nowak
    Citation: Cell Communication and Signaling 2022 20:63
  3. Pancreatic cancer is a highly malignant tumor and, is extremely difficult to diagnose and treat. Metastasis is one of the critical steps in the development of cancer and uses cell to cell communication to medi...

    Authors: Wenjie Zhang, Juan Xing, Tian Liu, Jie Zhang, Zhujiang Dai, Huan Zhang, Daorong Wang and Dong Tang
    Citation: Cell Communication and Signaling 2022 20:1
  4. The urinary tract is highly innervated by autonomic nerves which are essential in urinary tract development, the production of growth factors, and the control of homeostasis. These neural signals may become dy...

    Authors: M. Archer, N. Dogra, Z. Dovey, T. Ganta, H.-S. Jang, J. A. Khusid, A. Lantz, M. Mihalopoulos, J. A. Stockert, A. Zahalka, L. Björnebo, S. Gaglani, M. R. Noh, S. A. Kaplan, R. Mehrazin, K. K. Badani…
    Citation: Cell Communication and Signaling 2021 19:78
  5. Over a century of scientific inquiry since the discovery of v-SRC but still no final judgement on SRC function. However, a significant body of work has defined Src family kinases as key players in tumor progre...

    Authors: Maria A. Ortiz, Tatiana Mikhailova, Xiang Li, Baylee A. Porter, Alaji Bah and Leszek Kotula
    Citation: Cell Communication and Signaling 2021 19:67
  6. The ABL kinases, ABL1 and ABL2, promote tumor progression and metastasis in various solid tumors. Recent reports have shown that ABL kinases have increased expression and/or activity in solid tumors and that A...

    Authors: Jillian Hattaway Luttman, Ashley Colemon, Benjamin Mayro and Ann Marie Pendergast
    Citation: Cell Communication and Signaling 2021 19:59
  7. Alzheimer’s disease is one of the neurodegenerative diseases, characterized by the accumulation of abnormal protein deposits, which disrupts signal transduction in neurons and other glia cells. The pathologica...

    Authors: Smita Eknath Desale and Subashchandrabose Chinnathambi
    Citation: Cell Communication and Signaling 2021 19:28