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Emerging biomarkers in oncology research and practice

This thematic series of state-of-the-science publications covers cutting-edge developments in the field of oncology and pathology with reference to diagnostic, prognostic, predictive and pharmacodynamics biomarkers.

It includes articles on recent advances in discovery, methodology development, analytical and clinical validation and clinical qualification of novel tissue-based oncology biomarkers. Articles in the series also demonstrate the clinical utility and value of promising tissue-biomarkers in advancing the development of targeted therapeutics in oncology clinical trials and practice. 

The collection, guest edited by Dr. Aejaz Nasir, MD, MPhil, FCAP, is published in Cancer Cell International.

  1. Galectin-3 as a β-galactoside-binding protein, has been found to be involved in tumor cell growth, anti-apoptosis, adhesion, angiogenesis, invasion, and distant metastases, indicating that it may play a pivota...

    Authors: Yi Wang, Shiwei Liu, Ye Tian, Yamin Wang, Qijie Zhang, Xiang Zhou, Xianghu Meng and Ninghong Song
    Citation: Cancer Cell International 2018 18:172
  2. Inflammation is a major player in breast cancer (BC) progression. Allograft-inflammatory factor-1 (AIF1) is a crucial mediator in the inflammatory response. AIF1 reportedly plays a role in BC, but the mechanis...

    Authors: Ferial Amira Slim, Geneviève Ouellette, Kaoutar Ennour-Idrissi, Simon Jacob, Caroline Diorio and Francine Durocher
    Citation: Cancer Cell International 2018 18:167
  3. Follistatin (FST), an activin-binding protein, inhibits activin action by interfering with activin binding to its receptor. The prognostic value of FST has been studied in various cancers. However, these studi...

    Authors: Pengyu Zhang, Yingxin Ruan, Jun Xiao, Fangfang Chen and Xuejun Zhang
    Citation: Cancer Cell International 2018 18:162
  4. While the somatic mutation profiles of renal cell carcinoma (RCC) have been revealed by several studies worldwide, the overwhelming majority of those were not derived from Chinese patients. The landscape of so...

    Authors: Jie Wang, Zhijun Xi, Jianzhong Xi, Hanshuo Zhang, Juan Li, Yuchao Xia and Yuanxue Yi
    Citation: Cancer Cell International 2018 18:159
  5. Colorectal cancer (CRC) is one of the most common cancers diagnosed and among the commonest causes of cancer-related mortality globally. Despite the various available treatment options, millions of people stil...

    Authors: Adewale Oluwaseun Fadaka, Babajide A. Ojo, Olusola Bolaji Adewale, Temitope Esho and Ashley Pretorius
    Citation: Cancer Cell International 2018 18:130
  6. Multidrug resistance (MDR) is a major obstacle in breast cancer treatment. The predominant mechanism underlying MDR is an increase in the activity of adenosine triphosphate (ATP)-dependent drug efflux transpor...

    Authors: Shao-hsuan Wen, Shey-chiang Su, Bo-huang Liou, Cheng-hao Lin and Kuan-rong Lee
    Citation: Cancer Cell International 2018 18:128
  7. Increasing data has indicated an association between increased soluble B7-H3 (sB7-H3) levels and unfavorable prognosis in patients with malignancies. However, the level of sB7-H3 and its clinical significance ...

    Authors: Ling Wang, Fu-biao Kang, Guo-chuan Zhang, Juan Wang, Ming-fang Xie and Ying-ze Zhang
    Citation: Cancer Cell International 2018 18:115
  8. The aberrant regulation of MALAT1 has been indicated to be involved in various carcinogenic pathways contributing to the tumourigenesis and progression of cancers. The current meta-analysis summarized the rese...

    Authors: Juan Li, Zhigang Cui, Hang Li, Xiaoting Lv, Min Gao, Zitai Yang, Yanhong Bi, Ziwei Zhang, Shengli Wang, Baosen Zhou and Zhihua Yin
    Citation: Cancer Cell International 2018 18:109
  9. Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investiga...

    Authors: Yongchen Ma, Jing Zhu, Shanwen Chen, Tengyu Li, Ju Ma, Shihao Guo, Jianwen Hu, Taohua Yue, Junling Zhang, Pengyuan Wang, Xin Wang, Guowei Chen and Yucun Liu
    Citation: Cancer Cell International 2018 18:104
  10. Ferulic acid (4-hydroxy-3-methoxycinnamic acid, FA) is a hydroxycinnamic acid derived from a rich polyphenolic compound. This study aimed to investigate the effect of ferulic acid (4-hydroxy-3-methoxycinnamic ...

    Authors: Jinhua Gao, Hui Yu, Weikang Guo, Ying Kong, lina Gu, Qi Li, Shanshan Yang, Yunyan Zhang and Yaoxian Wang
    Citation: Cancer Cell International 2018 18:102
  11. The expression of the immunoregulatory protein B7-H4 has been reported in many types of cancer, including breast cancer. However, its role in triple-negative breast cancer (TNBC), especially its correlation wi...

    Authors: Ling Wang, Chao Yang, Xin-bo Liu, Li Wang and Fu-biao Kang
    Citation: Cancer Cell International 2018 18:100
  12. Gastro-esophageal adenocarcinomas (GEA) represent a severe global health burden and despite improvements in the multimodality treatment of these malignancies the prognosis of patients remains poor. HER2 overex...

    Authors: Francesca Battaglin, Madiha Naseem, Alberto Puccini and Heinz-Josef Lenz
    Citation: Cancer Cell International 2018 18:99
  13. Breast cancer (BC) is the most frequent malignancy among females worldwide. Despite several efforts and improvements in early diagnosis and treatment, there are still tumors characterized by an aggressive beha...

    Authors: Jessica Iorio, Icro Meattini, Simonetta Bianchi, Marco Bernini, Virginia Maragna, Luca Dominici, Donato Casella, Vania Vezzosi, Lorenzo Orzalesi, Jacopo Nori, Lorenzo Livi, Annarosa Arcangeli and Elena Lastraioli
    Citation: Cancer Cell International 2018 18:93
  14. Long non-coding RNAs play pivotal roles in the carcinogenesis of multiple types of cancers. This study is firstly to evaluate influence of rs4848320 and rs1110839 polymorphisms in long non-coding RNA AC016683....

    Authors: Juan Li, Hang Li, Xiaoting Lv, Zitai Yang, Min Gao, Yanhong Bi, Ziwei Zhang, Shengli Wang, Zhigang Cui, Baosen Zhou and Zhihua Yin
    Citation: Cancer Cell International 2018 18:91
  15. Lung cancer is a leading public health issue worldwide. Although therapeutic approaches have improved drastically in the last decades, the prognosis of lung cancer patients remains suboptimal. The canonical nu...

    Authors: Hualong Qin, Jun Zhou, Jingjing Xu, Li Cheng, Zaixiang Tang, Haitao Ma and Feng Guo
    Citation: Cancer Cell International 2018 18:88
  16. Ovarian cancer is a heterogeneous disease with a high degree of genomic instability, pro-/antitumor immunity and inflammation, and remains the most lethal gynecologic cancer worldwide. APOBEC3B, a member of th...

    Authors: Yan Du, Xiang Tao, Jing Wu, Huandi Yu, Yinhua Yu and Hongbo Zhao
    Citation: Cancer Cell International 2018 18:78
  17. Meningioma cancer stem cells (MCSCs) contribute to tumor aggressiveness and drug resistance. Successful therapies developed for inoperable, recurrent, or metastatic tumors must target these cells and restrict ...

    Authors: Hanin Alamir, Mona Alomari, Abdulla Ahmed A. Salwati, Mohamad Saka, Mohammed Bangash, Saleh Baeesa, Fahad Alghamdi, Angel Carracedo, Hans-Juergen Schulten, Adeel Chaudhary, Adel Abuzenadah and Deema Hussein
    Citation: Cancer Cell International 2018 18:77
  18. The aberrant expression of long non-coding RNA (lncRNA) X inactivate-specific transcript (XIST) has been demonstrated to be involved in the tumourigenesis and the development of various cancers. Therefore, we ...

    Authors: Huihui Mao, Kai Wang, Yuehua Feng, Jun Zhang, Lili Pan, Yuxia Zhan, Haijun Sheng and Guanghua Luo
    Citation: Cancer Cell International 2018 18:34