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Developing the evidence base for Traditional and Complementary Medicine

Guested edited by Dr Joanna Harnett and Dr Carolina Oi Lam Ung 

A thematic series published in Chinese Medicine

Chinese Medicine © Kay Ransom / Fotolia

Many scientists and clinicians around the world are working on developing and building the evidence base for the safety and efficacy of Traditional and Complementary Medicine (T&CM). Despite the substantial effort to evaluate the efficacy and safety of T&CM medicinal products and practices, often in the form of randomized controlled trials, there remains a general consensus that “for most conditions, there is not enough rigorous scientific evidence to know whether T&CM methods work for the conditions for which they are used”. Traditional Medicine practices that are indigenous to specific regions and cultures around the world are also considered to be largely under-investigated or under-reported. The global acceptance of T&CM as a preferred choice of healthcare is evidenced by the substantial global prevalence of use. Recently, the inclusion of Traditional Chinese Medicine into the ICD-11 represents an opportunity for T&CM to become an integral part of global health care in the UN member states and beyond. Therefore, it is critical to gather evidence that informs the development and execution of rigorous scientific research and regulatory processes that subsequently facilitates the effective and appropriate integration of T&CM into health care around the world.

In order to contribute to the evidence base that supports rigorous research, scientific regulation and appropriate integration of traditional medicines and therapies, we are delighted to host this thematic series “Developing the evidence base for Traditional and Complementary Medicine”. The overall goal is to highlight the importance of adopting an inter-disciplinary approach that strategically builds the evidence-base for T&CM approaches to health care.

  1. Complementary remedies such as the Chinese herb ‘Sheng Ma’ (Black cohosh; Actaea racemosa ‘AR’) are being sought to overcome the shortcomings of conventional hormonal and surgical therapies developed for the trea...

    Authors: Asmaa A. Azouz, Sara E. Ali, Reham M. Abd-Elsalam, Shimaa R. Emam, Mona K. Galal, Sherif H. Elmosalamy, Muhammed A. Alsherbiny, Bardes B. Hassan, Chun Guang Li and Shymaa A. El Badawy
    Citation: Chinese Medicine 2021 16:36
  2. The National Medical Products Administration (NMPA) in China has set to advance the regulatory capacity of traditional Chinese medicines (TCMs) with the adoption of regulatory science (RS). However, the priori...

    Authors: Zuanji Liang, Yunfeng Lai, Meng Li, Junnan Shi, Chi Ieong Lei, Hao Hu and Carolina Oi Lam Ung
    Citation: Chinese Medicine 2021 16:23
  3. Galli gigeriae endothelium corneum (GGEC) has been effectively used for centuries for the treatment of functional dyspepsia (FD) in clinical practice in Asian countries. However, its potential mechanism and ch...

    Authors: Shanshan Li, Meng Zheng, Zhentang Zhang, Hengying Peng, Wenling Dai and Jihua Liu
    Citation: Chinese Medicine 2021 16:22
  4. Shende’an tablet (SDA) is a newly capsuled Chinese herbal formula derived from the Chinese traditional medicine Zhengan Xifeng Decoction which is approved for the treatment of neurasthenia and insomnia in Chin...

    Authors: Xiaoyan Sheng, Shuiyuan Yang, Xiaomin Wen, Xin Zhang, Yongfeng Ye, Peng Zhao, Limin Zang, Kang Peng, Enming Du and Sai Li
    Citation: Chinese Medicine 2021 16:18
  5. This study was aimed to investigate the therapeutic effects and potential mechanism of higenamine combined with [6]-gingerol (HG/[6]-GR) against doxorubicin (DOX)—induced chronic heart failure (CHF) in rats.

    Authors: Jianxia Wen, Xiao Ma, Ming Niu, Junjie Hao, Ying Huang, Ruilin Wang, Ruisheng Li, Jian Wang and Yanling Zhao
    Citation: Chinese Medicine 2020 15:120
  6. Stroke in Chinese Medicine (CM) includes the concepts of ischemic and hemorrhagic strokes from Western Medicine and is a common disease in Hong Kong. This clinical practice guideline (CPG) aims to evaluate and...

    Authors: Linda L. D. Zhong, Wai Kun, Nannan Shi, Tat Chi Ziea, Bacon F. L. Ng, Ying Gao, Zhaoxiang Bian and Aiping Lu
    Citation: Chinese Medicine 2020 15:116
  7. Migraine is painful disease in which neurotransmitters related to pain transmission play an important role. Hejie Zhitong prescription (HJZT) has been used in the clinic as an effective prescription for the tr...

    Authors: Xinna Wang, Hongfei Zhao, Liming Liu, Ping Niu, Chao Zhai, Jinjian Li, Qiaoli Xu and Dexi Zhao
    Citation: Chinese Medicine 2020 15:105
  8. Moxibustion is one of the major interventions of Chinese medicine (CM). The systematic reviews (SRs) are essential references for evaluating the efficacy and safety of moxibustion interventions. This study aim...

    Authors: Ran Tian, Xuan Zhang, Si-Yao Li, Qi-Ying Aixinjueluo, Wai Ching Lam and Zhao-Xiang Bian
    Citation: Chinese Medicine 2020 15:104
  9. Poor access to healthcare in rural communities causes many people to seek herbalists who use medicinal plants for the treatment of various disease conditions. Most knowledge of traditional herbal medicine make...

    Authors: James Kiamba Mailu, Joseph Mwanzia Nguta, James Mucunu Mbaria and Mitchel Otieno Okumu
    Citation: Chinese Medicine 2020 15:95
  10. Huyang Yangkun Formula (HYYKF) was developed based on theory of traditional Chinese medicine as well as clinical experience and used to improve ovarian function of premature ovarian insufficiency (POI) patient...

    Authors: Meifang Li, Li Xie, Yang Li, Jian Liu, Guangning Nie and Hongyan Yang
    Citation: Chinese Medicine 2020 15:83
  11. Organic anion transporting polypeptides (OATPs) are important transporter proteins that are expressed at the plasma membrane of cells, where they mediate the influx of endogenous and exogenous substances inclu...

    Authors: Youmna Ali, Tahiatul Shams, Ke Wang, Zhengqi Cheng, Yue Li, Wenying Shu, Xiaofeng Bao, Ling Zhu, Michael Murray and Fanfan Zhou
    Citation: Chinese Medicine 2020 15:71
  12. At present, coronavirus disease 2019 (COVID-19), caused by infection with severe acute respiratory syndrome coronavirus 2, is spreading all over the world, with disastrous consequences for people of all countr...

    Authors: Xiaofeng Ruan, Peng Du, Kang Zhao, Jucun Huang, Hongmei Xia, Dan Dai, Shu Huang, Xiang Cui, Liming Liu and Jianjun Zhang
    Citation: Chinese Medicine 2020 15:62
  13. Salvia miltiorrhiza (Danshen, DS) and Panax notoginseng (Sanqi, SQ) are famous traditional Chinese herbs, and their herbal pair (DS–SQ) has been popular used as anti-thrombotic medicines. However, there is still ...

    Authors: Shi-Jun Yin, Ying-Qing Luo, Cong-Peng Zhao, Hua Chen, Zhang-Feng Zhong, Shengpeng Wang, Yi-Tao Wang and Feng-Qing Yang
    Citation: Chinese Medicine 2020 15:35
  14. Traditional Chinese medicine (TCM) encompasses numerous herbal formulas which play critical therapeutic roles through “multi-components, multi-targets and multi-pathways” mechanisms. Exploring the interaction ...

    Authors: Daiyan Zhang, Yun Zhang, Yan Gao, Xingyun Chai, Rongbiao Pi, Ging Chan and Yuanjia Hu
    Citation: Chinese Medicine 2020 15:25
  15. Ophiorrhiza pumila, belonging to the genus Ophiorrhiza (Rubiaceae), is distributed throughout tropical and subtropical Asia. In this study, we evaluated for the first time the anti-proliferation and anti-migratio...

    Authors: Hui Liu, Wanqin Liao, Lixia Fan, Zhaoguang Zheng, Dahai Liu, Qing-Wen Zhang, Anping Yang and Fang Liu
    Citation: Chinese Medicine 2020 15:11
  16. The standards for reporting interventions in clinical trials of cupping (STRICTOC), in the form of a checklist and explanations for users, were designed to improve reporting of cupping trials, particularly the...

    Authors: Xuan Zhang, Ran Tian, Wai Ching Lam, Yuting Duan, Fan Liu, Chen Zhao, Taixiang Wu, Hongcai Shang, Xudong Tang, Aiping Lyu and Zhaoxiang Bian
    Citation: Chinese Medicine 2020 15:10
  17. The potential adverse effects of conventional oral pharmacotherapy of osteoarthritis (OA) restrict their long-term use. Topical application of a Chinese herbal paste for relieving OA knee pain can be effective...

    Authors: Wing Sum Siu, Wai Ting Shum, Wen Cheng, Chun Wai Wong, Hoi Ting Shiu, Chun Hay Ko, Ping Chung Leung, Christopher Wai Kei Lam and Chun Kwok Wong
    Citation: Chinese Medicine 2019 14:55