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Diabetic Kidney Disease: Advances in Disease Burden, Etiology, Pathophysiology, and Therapies

Guest edited by Dr Bernard G. Jaar and Dr Justin Echouffo Tcheugui

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Chronic kidney disease is a common complication of diabetes (both type 1 and type 2), affecting at least 30% of diabetic individuals. Furthermore, chronic kidney disease is a strong risk factor for many adverse outcomes, especially cardiovascular disorders and mortality, and particularly among diabetic patients. Diabetes kidney disease is a complex condition, and there is a need to have a clinical practice that reflects the advances in our understanding of the pathophysiology, etiology, screening/prevention, and treatment of the condition. Our clinical practice and future research efforts would greatly benefit from an endeavor to summarize the many recent advances in the field.  In this collection, BMC Medicine will present a series of papers that highlights the complexity of diabetes kidney disease, and chart a path forward for investigating and more effectively managing the condition.

We are seeking submissions of original research articles on diabetes kidney disease, presenting novel, impactful advances into one or more of the following, but not limited to:

  • The burden of the condition and its related risk factors across countries and populations, including different ethnic groups
  • Recent developments in our understanding of the pathophysiology of diabetes kidney disease
  • Advances in the therapies used to address diabetes kidney disease, including investigational drugs
  • The approaches to effective early detection and/or prevention of diabetes kidney disease both in the clinical setting and at the population level 
  • The impact of technological development in the management of glycaemia 
  • The current state of transplant therapy for diabetes kidney disease, and future perspectives

We welcome direct submission of original research within the article collection's scope. Please submit directly to BMC Medicine, indicating in your cover letter that you are targeting this collection. Alternatively, you can email a pre-submission query to the editorial team at The collection will remain open and accept submissions until June 2022.

Guest Editors provided guidance on the scope of this collection and advised on commissioned content. However, they are not involved in editorial decision-making on papers submitted to this collection. All final editorial decisions are with the Editor-in-Chief, Dr. Lin Lee.​

  1. The pathogenesis of diabetic kidney disease (DKD) is complex, involving metabolic and hemodynamic factors. Although DKD has been established as a heritable disorder and several genetic studies have been conduc...

    Authors: Heejin Jin, Ye An Kim, Young Lee, Seung-hyun Kwon, Ah Ra Do, Sujin Seo, Sungho Won and Je Hyun Seo
    Citation: BMC Medicine 2023 21:16
  2. The empirical evidence remains inconclusive for an association between diabetes mellitus (DM) in children and early-onset kidney disease later in life, and little is known about the effects of DM types (i.e., ...

    Authors: Jiahong Sun, Ce Wang, Min Zhao, Priscilla M. Y. Lee, Bo Xi, Yongfu Yu and Jiong Li
    Citation: BMC Medicine 2022 20:428

    The Correction to this article has been published in BMC Medicine 2023 21:200

  3. Diabetic kidney disease (DKD), the most common cause of kidney failure and end-stage kidney disease worldwide, will develop in almost half of all people with type 2 diabetes. With the incidence of type 2 diabe...

    Authors: Thomas Forst, Chantal Mathieu, Francesco Giorgino, David C. Wheeler, Nikolaos Papanas, Roland E. Schmieder, Atef Halabi, Oliver Schnell, Marina Streckbein and Katherine R. Tuttle
    Citation: BMC Medicine 2022 20:337
  4. Chronic kidney disease (CKD) in people with diabetes is becoming an increasing major public health concern, disproportionately burdening low- and middle-income countries (LMICs). This rising burden is due to v...

    Authors: Cindy George, Justin B. Echouffo-Tcheugui, Bernard G. Jaar, Ikechi G. Okpechi and Andre P. Kengne
    Citation: BMC Medicine 2022 20:247
  5. Reliable assessment of glycemia is central to the management of diabetes. The kidneys play a vital role in maintaining glucose homeostasis through glucose filtration, reabsorption, consumption, and generation....

    Authors: Mohamed Hassanein and Tariq Shafi
    Citation: BMC Medicine 2022 20:117
  6. Data on the relations between kidney function abnormalities and stroke in type 2 diabetes are limited. We evaluated the associations of kidney function abnormalities and chronic kidney disease (CKD) stages wit...

    Authors: Arnaud D. Kaze, Bernard G. Jaar, Gregg C. Fonarow and Justin B. Echouffo-Tcheugui
    Citation: BMC Medicine 2022 20:127
  7. Clinical practice guidelines recommend sodium-glucose co-transporter 2 inhibitors (SGLT2is) to mitigate adverse kidney and cardiovascular outcomes in patients with type 2 diabetes (T2D), including patients wit...

    Authors: Csaba Kovesdy, Niklas Schmedt, Kerstin Folkerts, Kevin Bowrin, Hanaya Raad, Michael Batech and Linda Fried
    Citation: BMC Medicine 2022 20:2
  8. It is unclear whether insulin resistance (IR) contributes to excess mortality in patients with type 2 diabetes independent of diabetic kidney disease (DKD), which is strongly associated with IR and is a major ...

    Authors: Giuseppe Penno, Anna Solini, Emanuela Orsi, Enzo Bonora, Cecilia Fondelli, Roberto Trevisan, Monica Vedovato, Franco Cavalot, Gianpaolo Zerbini, Olga Lamacchia, Antonio Nicolucci and Giuseppe Pugliese
    Citation: BMC Medicine 2021 19:66