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Dissecting the role of immune responses in complex brain disorders

Guest editors: Philip de Jager and Carlos Cruchaga

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Neurodevelopmental, psychiatric and neurodegenerative diseases together contribute a high global burden of morbidity and mortality yet insights into underlying mechanisms of etiology, therapeutic advances and changes to clinical practice remain limited. The development and application of cutting edge technologies and approaches, including disease models, multi-omics, data integration, and artificial intelligence, have advanced our understanding of disease risk and mechanisms underlying these complex brain disorders. Research efforts in this area are expanding our knowledge of the impact of genetic and genomic variation on neuronal function and networks, and are further contributing to novel insights into neuro-immune interactions highlighting their prominent role in disease etiology and how these offer new diagnostic and therapeutic opportunities for translation to the clinic.

To capture advances in this growing, multi-disciplinary area, Genome Medicine is pleased to present a special issue entitled ‘Dissecting the role of immune responses in complex brain disorders: translational and clinical insights', guest edited by Dr. Philip de Jager, from the Center for Translational & Computational Neuroimmunology and the Taub Institute for Research on Alzheimer’s Disease and the Aging Brain at Columbia University and Dr. Carlos Cruchaga, from the Neurogenomics and Informatics Center at Washington University

This collection of articles has not been sponsored and articles will undergo the journal’s standard peer-review process. The Guest Editors declare that they have no competing interests. The Guest Editors serve an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.


  1. Alzheimer’s disease (AD) is a genetically complex and heterogeneous disorder with multifaceted neuropathological features, including β-amyloid plaques, neurofibrillary tangles, and neuroinflammation. Over the ...

    Authors: Mehdi Jorfi, Anna Maaser-Hecker and Rudolph E. Tanzi
    Citation: Genome Medicine 2023 15:6
  2. The rapid advancement of single-cell transcriptomics in neurology has allowed for profiling of post-mortem human brain tissue across multiple diseases. Over the past 3 years, several studies have examined tiss...

    Authors: Tain Luquez, Pallavi Gaur, Ivy M Kosater, Matti Lam, Dylan I Lee, Jason Mares, Fahad Paryani, Archana Yadav and Vilas Menon
    Citation: Genome Medicine 2022 14:136
  3. Neuropsychiatric disorders afflict a large portion of the global population and constitute a significant source of disability worldwide. Although Genome-wide Association Studies (GWAS) have identified many dis...

    Authors: Shuang Liu, Hyejung Won, Declan Clarke, Nana Matoba, Saniya Khullar, Yudi Mu, Daifeng Wang and Mark Gerstein
    Citation: Genome Medicine 2022 14:133
  4. There is large individual variation in both clinical presentation and progression between Parkinson’s disease patients. Generation of deeply and longitudinally phenotyped patient cohorts has enormous potential...

    Authors: Cynthia Sandor, Stephanie Millin, Andrew Dahl, Ann-Kathrin Schalkamp, Michael Lawton, Leon Hubbard, Nabila Rahman, Nigel Williams, Yoav Ben-Shlomo, Donald G. Grosset, Michele T. Hu, Jonathan Marchini and Caleb Webber
    Citation: Genome Medicine 2022 14:129
  5. Primary central nervous system lymphoma (PCNSL) is a rare lymphoma of the central nervous system, usually of diffuse large B cell phenotype. Stereotactic biopsy followed by histopathology is the diagnostic sta...

    Authors: Michael Heming, Svea Haessner, Jolien Wolbert, I-Na Lu, Xiaolin Li, Benjamin Brokinkel, Michael Müther, Markus Holling, Walter Stummer, Christian Thomas, Andreas Schulte-Mecklenbeck, Flavia de Faria, Marlon Stoeckius, Stephan Hailfinger, Georg Lenz, Kornelius Kerl…
    Citation: Genome Medicine 2022 14:109
  6. Emerging RNA viruses that target the central nervous system (CNS) lead to cognitive sequelae in survivors. Studies in humans and mice infected with West Nile virus (WNV), a re-emerging RNA virus associated wit...

    Authors: Sarah F. Rosen, Allison L. Soung, Wei Yang, Shenjian Ai, Marlene Kanmogne, Veronica A. Davé, Maxim Artyomov, Jeffrey A. Magee and Robyn S. Klein
    Citation: Genome Medicine 2022 14:108
  7. The cerebrospinal fluid (CSF) features a unique immune cell composition and is in constant contact with the brain borders, thus permitting insights into the brain to diagnose and monitor diseases. Recently, th...

    Authors: Michael Heming, Anna-Lena Börsch, Heinz Wiendl and Gerd Meyer zu Hörste
    Citation: Genome Medicine 2022 14:94
  8. Recent investigations of the meninges have highlighted the importance of the dura layer in central nervous system immune surveillance beyond a purely structural role. However, our understanding of the meninges...

    Authors: Anthony Z. Wang, Jay A. Bowman-Kirigin, Rupen Desai, Liang-I Kang, Pujan R. Patel, Bhuvic Patel, Saad M. Khan, Diane Bender, M. Caleb Marlin, Jingxian Liu, Joshua W. Osbun, Eric C. Leuthardt, Michael R. Chicoine, Ralph G. Dacey Jr, Gregory J. Zipfel, Albert H. Kim…
    Citation: Genome Medicine 2022 14:49
  9. Depression is a disabling and highly prevalent condition where genetic and epigenetic, such as DNA methylation (DNAm), differences contribute to disease risk. DNA methylation is influenced by genetic variation...

    Authors: Xueyi Shen, Doretta Caramaschi, Mark J. Adams, Rosie M. Walker, Josine L. Min, Alex Kwong, Gibran Hemani, Miruna C. Barbu, Heather C. Whalley, Sarah E. Harris, Ian J. Deary, Stewart W. Morris, Simon R. Cox, Caroline L. Relton, Riccardo E. Marioni, Kathryn L. Evans…
    Citation: Genome Medicine 2022 14:36
  10. The Colombian population, as well as those in other Latin American regions, arose from a recent tri-continental admixture among Native Americans, Spanish invaders, and enslaved Africans, all of whom passed thr...

    Authors: Juliana Acosta-Uribe, David Aguillón, J. Nicholas Cochran, Margarita Giraldo, Lucía Madrigal, Bradley W. Killingsworth, Rijul Singhal, Sarah Labib, Diana Alzate, Lina Velilla, Sonia Moreno, Gloria P. García, Amanda Saldarriaga, Francisco Piedrahita, Liliana Hincapié, Hugo E. López…
    Citation: Genome Medicine 2022 14:27
  11. Alzheimer’s disease (AD) is characterized by robust microgliosis and phenotypic changes that accompany disease pathogenesis. Accumulating evidence from genetic studies suggests the importance of phospholipase ...

    Authors: Andy P. Tsai, Chuanpeng Dong, Peter Bor-Chian Lin, Evan J. Messenger, Brad T. Casali, Miguel Moutinho, Yunlong Liu, Adrian L. Oblak, Bruce T. Lamb, Gary E. Landreth, Stephanie J. Bissel and Kwangsik Nho
    Citation: Genome Medicine 2022 14:17
  12. Deletions and duplications of the multigenic 16p11.2 and 22q11.2 copy number variant (CNV) regions are associated with brain-related disorders including schizophrenia, intellectual disability, obesity, bipolar...

    Authors: Mikhail Vysotskiy, Xue Zhong, Tyne W. Miller-Fleming, Dan Zhou, Nancy J. Cox and Lauren A. Weiss
    Citation: Genome Medicine 2021 13:172
  13. In spite of many years of research, our understanding of the molecular bases of Alzheimer’s disease (AD) is still incomplete, and the medical treatments available mainly target the disease symptoms and are har...

    Authors: Eduardo Pauls, Sergi Bayod, Lídia Mateo, Víctor Alcalde, Teresa Juan-Blanco, Marta Sánchez-Soto, Takaomi C. Saido, Takashi Saito, Antoni Berrenguer-Llergo, Camille Stephan-Otto Attolini, Marina Gay, Eliandre de Oliveira, Miquel Duran-Frigola and Patrick Aloy
    Citation: Genome Medicine 2021 13:168