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Recent advances in disseminated intravascular coagulation

Edited by Prof Satoshi Gando

This article collection is published in Journal of Intensive Care. A half century ago, the concept of disseminated intravascular coagulation (DIC) was ridiculed to be an abbreviation for  Disseminated International Confusion, because intravascular fibrin thrombosis was hardly ever found at autopsy. Since the end of last century, however, it has been emphasized that DIC equals a sign that “Death Is Coming”. DIC is now recognized an independent disease entity characterized by the intravascular activation of coagulation with loss of localization arising from different causes, including trauma and sepsis. It can originate from and cause damage to the microvasculature, which if sufficiently severe, can produce organ dysfunction, leading to poor prognosis of the patients.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

  1. Microparticles (MPs) are small membrane vesicles that are released from many different cell types by exocytic budding of the plasma membrane in response to cellular activation or apoptosis. MPs may also be inv...

    Authors: Shosaku Nomura and Michiomi Shimizu
    Citation: Journal of Intensive Care 2015 3:2
  2. Antithrombin (AT) is known as an important physiological anticoagulant. AT inactivates thrombin and multiple other coagulation factors, thereby strongly inhibiting the over-activation of the coagulation system...

    Authors: Toshiaki Iba and Daizoh Saitoh
    Citation: Journal of Intensive Care 2014 2:66
  3. Thrombosis is generally considered harmful because it compromises the blood supply to organs. However, recent studies have suggested that thrombosis under certain circumstances plays a major physiological role...

    Authors: Takashi Ito
    Citation: Journal of Intensive Care 2014 2:65
  4. Disseminated intravascular coagulation (DIC) is categorized into bleeding, organ failure, massive bleeding, and non-symptomatic types according to the sum of vectors for hypercoagulation and hyperfibrinolysis....

    Authors: Hideo Wada, Takeshi Matsumoto and Yoshiki Yamashita
    Citation: Journal of Intensive Care 2014 2:15