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Inorganic nanoparticles and cellular mechanobiology: from nanotoxicology to cytoskeleton-targeting nanotheranostics

Call for papers

Guest Editors: Vladimir Mulens-Arias (National Center for Biotechnology, Spain), Stefaan Soenen (KU Leuven, Belgium).

J Nanobiotechnology invites submissions to a collection onFluorescent Cells Inorganic nanoparticles and cellular mechanobiology: from nanotoxicology to cytoskeleton-targeting nanotheranostics

The ever-growing research on nanoparticle use in biomedical applications poses concerns on how nanoparticles interact with cells beyond their intended theranostic purposes. Particularly, researchers have been focusing on how nanoparticles affect the cytoskeleton dynamic in the last decade.  Such interest arises from the need to understand and elucidate the biophysical and biochemical forces underlying the interaction of nanoparticles with the filaments composing the cell cytoskeleton and the adhesive structures. Noteworthy, adhesions (filipodia, focal adhesions, podosomes, invadopodia) connect the intracellular cytoskeleton network with the extracellular matrix (ECM) through mechanosensitive and biochemical signaling and mediates cellular sensing of ECM and cell migration/invasion. Since cytoskeleton and adhesome dynamics are integral to cell migration and invasion, and, thus, to physiological (e.g., angiogenesis, immune response, embryogenesis) and pathological processes (e.g., cancer development and metastasis, toxicology, and injured tissue repair), it is only logical to hypothesize that should nanoparticles interfere with the former, it would have consequences for the latter. Therefore, this special issue aims at promoting and outlining the current knowledge on nanoparticle´s effect on cytoskeleton and adhesome dynamics, and how it affects the underlying biological processes such as embryogenesis, immune response, angiogenesis, tissue repair, cancer, and metastasis. Hence, it is with great pleasure that we invite authors to submit original research papers and reviews for this Special Issue.

The potential subjects concern, but are not limited to:

  • Biophysical and biochemical study of the interaction of non-targeted nanoparticles and cytoskeleton in a cell-free and a cellular system
  • Biophysical study of mechanical forces in nanoparticle-treated cells
  • Non-targeted nanoparticle interference with the cytoskeleton and adhesion dynamics and its consequences for cell migration/invasion within the context of different physiological and pathological scenario (cancer, metastasis, angiogenesis, embryogenesis, cell therapy)
  • Nanoparticle interaction with cytoskeleton and biocompatibility
  • Use of nanoparticles for targeting of cytoskeleton components for theranostic purposes

Submission deadline: 30th March 2021. Please indicate at the Additional Information stage of submission that you are submitting to the Inorganic nanoparticles and cellular mechanobiology article collection. All manuscripts received will be subject to peer review as is standard for the journal.

Articles will be published continuously in the main journal and highlighted on the collection homepage as soon as they are ready.

  1. The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brough...

    Authors: Jose E. Perez, Florian Fage, David Pereira, Ali Abou-Hassan, Sophie Asnacios, Atef Asnacios and Claire Wilhelm

    Citation: Journal of Nanobiotechnology 2021 19:117

    Content type: Research

    Published on:

  2. It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one of challenges, let alone selective suppression of cancer growth by regulating the cellular microenvironment. ...

    Authors: Daomei Chen, Bin Li, Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia, Xie, Zijuan He and Jiaqiang Wang

    Citation: Journal of Nanobiotechnology 2021 19:68

    Content type: Research

    Published on:

  3. Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparti...

    Authors: Youssef Abdalla, Meihua Luo, Ermei Mäkilä, Bryan W. Day, Nicolas H. Voelcker and Wing Yin Tong

    Citation: Journal of Nanobiotechnology 2021 19:60

    Content type: Research

    Published on:

  4. The cellular response to nanoparticles (NPs) for the mechanical clue and biochemical changes are unexplored. Here, we provide the comprehensive analysis of the Chinese Hamster Ovary (CHO-K1) cell line to study...

    Authors: Karmveer Yadav, Syed Azmal Ali, Ashok Kumar Mohanty, Eshwarmoorthy Muthusamy, Kesavan Subaharan and Gautam Kaul

    Citation: Journal of Nanobiotechnology 2021 19:45

    Content type: Research

    Published on:

  5. Nanoparticles are being increasingly used in biomedical applications owing to their unique physical and chemical properties and small size. However, their biophysical assessment and evaluation of side-effects ...

    Authors: Tae Hwan Shin, Abdurazak Aman Ketebo, Da Yeon Lee, Seungah Lee, Seong Ho Kang, Shaherin Basith, Balachandran Manavalan, Do Hyeon Kwon, Sungsu Park and Gwang Lee

    Citation: Journal of Nanobiotechnology 2021 19:21

    Content type: Research

    Published on:

  6. Nanoparticles (NPs) can enter cells and cause cellular dysfunction. For example, reactive oxygen species generated by NPs can damage the cytoskeleton and impair cellular adhesion properties. Previously, we rep...

    Authors: Abdurazak Aman Ketebo, Tae Hwan Shin, Myeongjun Jun, Gwang Lee and Sungsu Park

    Citation: Journal of Nanobiotechnology 2020 18:170

    Content type: Research

    Published on: