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Inorganic nanoparticles and cellular mechanobiology: from nanotoxicology to cytoskeleton-targeting nanotheranostics

Inorganic nanoparticles and cellular mechanobiology: from nanotoxicology to cytoskeleton-targeting nanotheranostics

Guest Editors: Vladimir Mulens-Arias (National Center for Biotechnology, Spain), Stefaan Soenen (KU Leuven, Belgium).

J Nanobiotechnology presents a collection onFluorescent Cells Inorganic nanoparticles and cellular mechanobiology: from nanotoxicology to cytoskeleton-targeting nanotheranostics

The ever-growing research on nanoparticle use in biomedical applications poses concerns on how nanoparticles interact with cells beyond their intended theranostic purposes. Particularly, researchers have been focusing on how nanoparticles affect the cytoskeleton dynamic in the last decade.  Such interest arises from the need to understand and elucidate the biophysical and biochemical forces underlying the interaction of nanoparticles with the filaments composing the cell cytoskeleton and the adhesive structures. Noteworthy, adhesions (filipodia, focal adhesions, podosomes, invadopodia) connect the intracellular cytoskeleton network with the extracellular matrix (ECM) through mechanosensitive and biochemical signaling and mediates cellular sensing of ECM and cell migration/invasion. Since cytoskeleton and adhesome dynamics are integral to cell migration and invasion, and, thus, to physiological (e.g., angiogenesis, immune response, embryogenesis) and pathological processes (e.g., cancer development and metastasis, toxicology, and injured tissue repair), it is only logical to hypothesize that should nanoparticles interfere with the former, it would have consequences for the latter. Therefore, this special issue aims at promoting and outlining the current knowledge on nanoparticle´s effect on cytoskeleton and adhesome dynamics, and how it affects the underlying biological processes such as embryogenesis, immune response, angiogenesis, tissue repair, cancer, and metastasis. 

The potential subjects concern, but are not limited to:

  • Biophysical and biochemical study of the interaction of non-targeted nanoparticles and cytoskeleton in a cell-free and a cellular system
  • Biophysical study of mechanical forces in nanoparticle-treated cells
  • Non-targeted nanoparticle interference with the cytoskeleton and adhesion dynamics and its consequences for cell migration/invasion within the context of different physiological and pathological scenario (cancer, metastasis, angiogenesis, embryogenesis, cell therapy)
  • Nanoparticle interaction with cytoskeleton and biocompatibility
  • Use of nanoparticles for targeting of cytoskeleton components for theranostic purposes

This collection is now closed to new submissions.

  1. The interactions between nanoparticles and the biological environment have long been studied, with toxicological assays being the most common experimental route. In parallel, recent growing evidence has brough...

    Authors: Jose E. Perez, Florian Fage, David Pereira, Ali Abou-Hassan, Sophie Asnacios, Atef Asnacios and Claire Wilhelm
    Citation: Journal of Nanobiotechnology 2021 19:117
  2. It was shown that some nanomaterials may have anticancer properties, but lack of selectivity is one of challenges, let alone selective suppression of cancer growth by regulating the cellular microenvironment. ...

    Authors: Daomei Chen, Bin Li, Tao Lei, Di Na, Minfang Nie, Yepeng Yang, Congjia, Xie, Zijuan He and Jiaqiang Wang
    Citation: Journal of Nanobiotechnology 2021 19:68
  3. Approximately 80% of brain tumours are gliomas. Despite treatment, patient mortality remains high due to local metastasis and relapse. It has been shown that transferrin-functionalised porous silicon nanoparti...

    Authors: Youssef Abdalla, Meihua Luo, Ermei Mäkilä, Bryan W. Day, Nicolas H. Voelcker and Wing Yin Tong
    Citation: Journal of Nanobiotechnology 2021 19:60
  4. The cellular response to nanoparticles (NPs) for the mechanical clue and biochemical changes are unexplored. Here, we provide the comprehensive analysis of the Chinese Hamster Ovary (CHO-K1) cell line to study...

    Authors: Karmveer Yadav, Syed Azmal Ali, Ashok Kumar Mohanty, Eshwarmoorthy Muthusamy, Kesavan Subaharan and Gautam Kaul
    Citation: Journal of Nanobiotechnology 2021 19:45
  5. Nanoparticles are being increasingly used in biomedical applications owing to their unique physical and chemical properties and small size. However, their biophysical assessment and evaluation of side-effects ...

    Authors: Tae Hwan Shin, Abdurazak Aman Ketebo, Da Yeon Lee, Seungah Lee, Seong Ho Kang, Shaherin Basith, Balachandran Manavalan, Do Hyeon Kwon, Sungsu Park and Gwang Lee
    Citation: Journal of Nanobiotechnology 2021 19:21
  6. Nanoparticles (NPs) can enter cells and cause cellular dysfunction. For example, reactive oxygen species generated by NPs can damage the cytoskeleton and impair cellular adhesion properties. Previously, we rep...

    Authors: Abdurazak Aman Ketebo, Tae Hwan Shin, Myeongjun Jun, Gwang Lee and Sungsu Park
    Citation: Journal of Nanobiotechnology 2020 18:170