Skip to main content

Control strategy and case management of human brucellosis

Guest edited by David O’Callaghan, Jun-Xia Song, Adrian M. Whatmore, Caterina Guzmán Verri, and Xiao-Nong Zhou

A thematic series published in Infectious Diseases of Poverty

brucella © © Manjurul / Getty Images / iStock

Brucellosis is a widespread zoonosis mainly transmitted from cattle, sheep, goats, pigs and camels through direct contact with blood, placenta, fetuses or uterine secretions, or through consumption of contaminated raw animal products. In endemic areas, human brucellosis has serious public health consequences. It is a disease of poverty, a huge socioeconomic cost not only occurred when livestock infected with bacteria of the genus Brucella, but also as human brucellosis that starts as a debilitating acute infection and can become chronic with many complications.

In most countries, brucellosis is a notifiable disease. Control of brucellosis requires a ‘One Health’ strategy. Animal and human health must work together to prevent human infection by raising awareness, food-safety measures, occupational hygiene and laboratory safety, and good performance of surveillance in human and animal populations. We need to develop better tools to be used in control programmes, efficient and safe vaccines, and diagnostic tests with high specificity and sensitivity that will be accessible to low income countries.

The series covers a wide range of research interests ranging from animal-human transmission, intervention and case management, diagnostics and veterinary/human medicine, strain identification and molecular epidemiology. 

  1. Brucellosis is a common zoonotic infectious disease in China. This study aimed to investigate the incidence trends of brucellosis in China, construct an optimal prediction model, and analyze the driving role o...

    Authors: Hui Chen, Meng-Xuan Lin, Li-Ping Wang, Yin-Xiang Huang, Yao Feng, Li-Qun Fang, Lei Wang, Hong-Bin Song and Li-Gui Wang
    Citation: Infectious Diseases of Poverty 2023 12:36
  2. A new candidate vector vaccine against human brucellosis based on recombinant influenza viral vectors (rIVV) subtypes H5N1 expressing Brucella outer membrane protein (Omp) 16, L7/L12, Omp19 or Cu–Zn SOD proteins ...

    Authors: Dina Bugybayeva, Zhailaubay Kydyrbayev, Nadezhda Zinina, Nurika Assanzhanova, Bolat Yespembetov, Yerken Kozhamkulov, Kunsulu Zakarya, Sholpan Ryskeldinova and Kaissar Tabynov
    Citation: Infectious Diseases of Poverty 2021 10:13
  3. Brucellosis is a major public health issue in China, while its temporal and spatial distribution have not been studied in depth. This study aims to better understand the epidemiology of brucellosis in the main...

    Authors: Pei-Feng Liang, Yuan Zhao, Jian-Hua Zhao, Dong-Feng Pan and Zhong-Qin Guo
    Citation: Infectious Diseases of Poverty 2020 9:142
  4. Previous studies showed that soluble IL-2Rα is an important marker of cellular immune activation and might be a marker of treatment efficacy for children with brucellosis. However, data regarding adult patient...

    Authors: Hua-Li Sun, Cheng-Jie Ma, Xiu-Fang Du, Si-Yuan Yang, Xiao Lv, Hong Zhao, Ling-Hang Wang, Yun-Xia Tang, Xing-Wang Li and Rong-Meng Jiang
    Citation: Infectious Diseases of Poverty 2020 9:92
  5. Hinggan League is located in the Northeast of the Inner Mongolia Autonomous Region, the historically endemic area of animal and human brucellosis. In this study, the epidemiological characteristics of human br...

    Authors: Hai-Tao Yuan, Cheng-Ling Wang, Li-Na Liu, Dan Wang, Dan Li, Zhen-Jun Li and Zhi-Guo Liu
    Citation: Infectious Diseases of Poverty 2020 9:79
  6. Brucellosis is a neglected zoonosis. It causes acute febrile illness and a potentially debilitating chronic infection in humans, and livestock infection has substantial socioeconomic impact. Over the past two ...

    Authors: Hai Jiang, David O’Callaghan and Jia-Bo Ding
    Citation: Infectious Diseases of Poverty 2020 9:55
  7. The incidence of brucellosis, which is caused by the Brucella species of bacteria, is rapidly rising worldwide; however, few studies have investigated the immune response to this pathogen and clinical biochemical...

    Authors: Zhi-Qiang Lin, Guo-Yue Lin, Wen-Wen He, Chi Zhang, Rui Zhang, Yuan-Da Li, Fan Wang, Ying Qin, Li Duan, Dou-Dou Zhao, Xiao-Juan Qu, Hui Gao and Hai Jiang
    Citation: Infectious Diseases of Poverty 2020 9:47