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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. Obesity and steatosis are associated with COVID-19 severe pneumonia. Elevated levels of pro-inflammatory cytokines and reduced immune response are typical of these patients. In particular, adipose tissue is th...

    Authors: Antonino De Lorenzo, Maria Grazia Tarsitano, Carmela Falcone, Laura Di Renzo, Lorenzo Romano, Sebastiano Macheda, Anna Ferrarelli, Demetrio Labate, Marco Tescione, Federico Bilotta and Paola Gualtieri

    Citation: Journal of Translational Medicine 2020 18:299

    Content type: Research

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  2. The severe acute respiratory syndrome virus SARS-CoV-2, a close relative of the SARS-CoV virus, is the cause of the recent COVID-19 pandemic affecting, to date, over 14 million individuals across the globe and...

    Authors: Nophar Geifman and Anthony D. Whetton

    Citation: Journal of Translational Medicine 2020 18:297

    Content type: Research

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  3. The World Health Organization declared on March 11, 2020, that the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) has escalated from epidemic into pandemic. As the initial outbreak ...

    Authors: Yuxi Li, Juan Li, Dongling Zhong, Yue Zhang, Yonggang Zhang, Yan Guo, Mike Clarke and Rongjiang Jin

    Citation: Systematic Reviews 2020 9:170

    Content type: Protocol

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  4. Disabled people are particularly exposed to the risks of COVID-19, as well as to the measures taken to address it, and their impact. The aim of the study was to examine the disability-inclusiveness of governme...

    Authors: Dikaios Sakellariou, Ana Paula Serrata Malfitano and Elena S. Rotarou

    Citation: International Journal for Equity in Health 2020 19:131

    Content type: Research

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  5. More severe cases of COVID- 19 are more likely to be hospitalized and around one-fifth, needing ICU admission. Understanding the common laboratory features of COVID-19 in more severe cases versus non-severe pa...

    Authors: Sulmaz Ghahramani, Reza Tabrizi, Kamran B. Lankarani, Seyyed Mohammad Amin Kashani, Shahla Rezaei, Nazanin Zeidi, Maryam Akbari, Seyed Taghi Heydari, Hamed Akbari, Peyman Nowrouzi-Sohrabi and Fariba Ahmadizar

    Citation: European Journal of Medical Research 2020 25:30

    Content type: Review

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  6. Stage 1: To evaluate the safety and efficacy of candidate agents as add-on therapies to standard of care (SoC) in patients hospitalised with COVID-19 in a screening stage.

    Authors: Tom Wilkinson, Rupert Dixon, Clive Page, Miles Carroll, Gareth Griffiths, Ling-Pei Ho, Anthony De Soyza, Timothy Felton, Keir E. Lewis, Karen Phekoo, James D. Chalmers, Anthony Gordon, Lorcan McGarvey, Jillian Doherty, Robert C. Read, Manu Shankar-Hari…

    Citation: Trials 2020 21:691

    Content type: Letter

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  7. Covid-19 morbidity and mortality are associated with a dysregulated immune response. Tools are needed to enhance existing immune profiling capabilities in affected patients. Here we aimed to develop an approac...

    Authors: Darawan Rinchai, Basirudeen Syed Ahamed Kabeer, Mohammed Toufiq, Zohreh Tatari-Calderone, Sara Deola, Tobias Brummaier, Mathieu Garand, Ricardo Branco, Nicole Baldwin, Mohamed Alfaki, Matthew C. Altman, Alberto Ballestrero, Matteo Bassetti, Gabriele Zoppoli, Andrea De Maria, Benjamin Tang…

    Citation: Journal of Translational Medicine 2020 18:291

    Content type: Research

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  8. Coronavirus disease 2019 (COVID-19) is spreading fast all around the world with more than fourteen millions of detected infected cases and more than 600.000 deaths by 20th July 2020. While scientist are workin...

    Authors: Alberto Sainz-Cort and Joost H. Heeroma

    Citation: Journal of Cannabis Research 2020 2:23

    Content type: Commentary

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  9. Coronavirus disease 2019 (COVID-19) is a new global public health emergency. The therapeutic benefits of Cold‒Damp Plague Formula (CDPF) against COVID-19, which was used to treat “cold‒dampness stagnation in t...

    Authors: Lin Han, Xiu-Xiu Wei, Yu-Jiao Zheng, Li-Li Zhang, Xin-Miao Wang, Hao-Yu Yang, Xu Ma, Lin-Hua Zhao and Xiao-Lin Tong

    Citation: Chinese Medicine 2020 15:78

    Content type: Research

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  10. The health crisis caused by COVID-19 has led many countries to opt for social quarantine of the population. During this quarantine, communication systems have been characterized by disintermediation, the accelera...

    Authors: Álex Escolà-Gascón, Francesc-Xavier Marín, Jordi Rusiñol and Josep Gallifa

    Citation: Globalization and Health 2020 16:72

    Content type: Research

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  11. The aim of this study is to assess the efficacy of the use of pre-exposure prophylaxis (PrEP) with hydroxychloroquine against placebo in healthcare workers with high risk of severe acute respiratory syndrome c...

    Authors: Berta Grau-Pujol, Daniel Camprubí, Helena Marti-Soler, Marc Fernández-Pardos, Caterina Guinovart and Jose Muñoz

    Citation: Trials 2020 21:688

    Content type: Letter

    Published on:

  12. Coronavirus disease 2019 (COVID-19) is a new respiratory and systemic disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The purpose of the present study was to investiga...

    Authors: Li-Da Chen, Zhen-Yu Zhang, Xiao-Jie Wei, Yu-Qing Cai, Weng-Zhen Yao, Ming-Hui Wang, Qiu-Fen Huang and Xiao-Bin Zhang

    Citation: Respiratory Research 2020 21:201

    Content type: Research

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  13. By mid-May 2020, there were over 1.5 million cases of (SARS-CoV-2) or COVID-19 across the U.S. with new confirmed cases continuing to rise following the re-opening of most states. Prior studies have focused ma...

    Authors: Yelena Rozenfeld, Jennifer Beam, Haley Maier, Whitney Haggerson, Karen Boudreau, Jamie Carlson and Rhonda Medows

    Citation: International Journal for Equity in Health 2020 19:126

    Content type: Research

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  14. Headache is one of the most frequent neurologic manifestations in COVID-19. We aimed to analyze which symptoms and laboratory abnormalities were associated with the presence of headache and to evaluate if pati...

    Authors: Javier Trigo, David García-Azorín, Álvaro Planchuelo-Gómez, Enrique Martínez-Pías, Blanca Talavera, Isabel Hernández-Pérez, Gonzalo Valle-Peñacoba, Paula Simón-Campo, Mercedes de Lera, Alba Chavarría-Miranda, Cristina López-Sanz, María Gutiérrez-Sánchez, Elena Martínez-Velasco, María Pedraza, Álvaro Sierra, Beatriz Gómez-Vicente…

    Citation: The Journal of Headache and Pain 2020 21:94

    Content type: Research article

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  15. The COVID pandemic has been devastating for not only its direct impact on lives, physical health, socio-economic status of individuals, but also for its impact on mental health. Some individuals are affected p...

    Authors: Pallab K. Maulik, Graham Thornicroft and Shekhar Saxena

    Citation: International Journal of Mental Health Systems 2020 14:57

    Content type: Debate

    Published on:

  16. COVID-19 has taken the world by surprise; even the most sophisticated healthcare systems have been unable to cope with the volume of patients and lack of resources. Yet the gradual spread of the virus in Leban...

    Authors: Zavi Lakissian, Rami Sabouneh, Rida Zeineddine, Joe Fayad, Rim Banat and Rana Sharara-Chami

    Citation: Advances in Simulation 2020 5:15

    Content type: Research

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  17. The novel coronavirus disease 2019 (COVID-19) pandemic is a global crisis, challenging healthcare systems worldwide. Many patients present with a remarkable disconnect in rest between profound hypoxemia yet wi...

    Authors: Sebastiaan Dhont, Eric Derom, Eva Van Braeckel, Pieter Depuydt and Bart N. Lambrecht

    Citation: Respiratory Research 2020 21:198

    Content type: Review

    Published on:

  18. The outbreak of 2019 coronavirus disease (COVID-19) could increase the risk of depression. However, epidemiological data on outbreak-associated depressive morbidity of female adolescents are not available. Thi...

    Authors: Jiaojiao Zhou, Xiaofei Yuan, Han Qi, Rui Liu, Yaqiong Li, Huanhuan Huang, Xu Chen and Gang Wang

    Citation: Globalization and Health 2020 16:69

    Content type: Research

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  19. In an effort to prevent infants being infected with SARS-CoV-2, some governments, professional organisations, and health facilities are instituting policies that isolate newborns from their mothers and otherwi...

    Authors: Karleen Gribble, Roger Mathisen, Mija-tesse Ververs and Anna Coutsoudis

    Citation: International Breastfeeding Journal 2020 15:67

    Content type: Commentary

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  20. From December 25, 2019 to January 31, 2020, 33 cases of the coronavirus disease 2019 (COVID-19) were identified in the Department of Respiratory and Critical Care Medicine of Zhongnan Hospital of Wuhan Univers...

    Authors: Gu-Qin Zhang, Hua-Qin Pan, Xing-Xing Hu, Shao-Jun He, Yi-Fei Chen, Chao-Jie Wei, Lan Ni, Li-Ping Zhang, Zhen-Shun Cheng and Jiong Yang

    Citation: Infectious Diseases of Poverty 2020 9:104

    Content type: Short Report

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  21. Acute respiratory distress syndrome (ARDS) develops rapidly and has a high mortality rate. Survivors usually have low quality of life. Current clinical management strategies are respiratory support and restric...

    Authors: Kun Xiao, Fei Hou, Xiuyu Huang, Binbin Li, Zhi Rong Qian and Lixin Xie

    Citation: Stem Cell Research & Therapy 2020 11:305

    Content type: Review

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  22. Oxygen saturation to fraction of inspired oxygen ratio (SpO2/FiO2) has been described as potential predictor of poor outcome for COVID-19, without considering its time-varying behavior though.

    Authors: Xiaofan Lu, Liyun Jiang, Taige Chen, Yang Wang, Bing Zhang, Yizhou Hong, Jun Wang and Fangrong Yan

    Citation: Respiratory Research 2020 21:194

    Content type: Letter to the Editor

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  23. From the begging months of 2020 a severe acute respiratory syndrome coronavirus (SARS-CoV-2, also called 2019-nCoV) caused a devastating global outbreak. At present, the diagnosis of coronavirus disease 2019 (...

    Authors: Omid Fakheran, Mandana Dehghannejad and Abbasali Khademi

    Citation: Infectious Diseases of Poverty 2020 9:100

    Content type: Scoping Review

    Published on:

  24. In the pandemic “Corona Virus Disease 2019” (COVID-19) people with diabetes have a high risk to require ICU admission. The management of diabetes in Intensive Care Unit is always challenging, however, when dia...

    Authors: Antonio Ceriello, Eberhard Standl, Doina Catrinoiu, Baruch Itzhak, Nebojsa M. Lalic, Dario Rahelic, Oliver Schnell, Jan Škrha and Paul Valensi

    Citation: Cardiovascular Diabetology 2020 19:114

    Content type: Review

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  25. The outbreak of coronavirus disease 2019 (COVID-19) has caused a public catastrophe and global concern. The main symptoms of COVID-19 are fever, cough, myalgia, fatigue and lower respiratory tract infection si...

    Authors: Xue-Yan Zhang, Hao-Jie Huang, Dong-Lin Zhuang, Moussa Ide Nasser, Ming-Hua Yang, Ping Zhu and Ming-Yi Zhao

    Citation: Infectious Diseases of Poverty 2020 9:99

    Content type: Scoping Review

    Published on:

  26. Over 4.2 million confirmed cases and more than 285,000 deaths, COVID-19 pandemic continues to harm significant number of people worldwide. Several studies have reported the impact of COVID-19 in general popula...

    Authors: Binny Thomas, Abdulrouf Pallivalapila, Wessam El Kassem, Asma Tarannum, Fatema Al Hail, Mohammed Rijims, Hussain Parappil, Arabo Ibrahim Bayo, Shamsa Ahmad, Zachariah Nazar, Derek Stewart and Moza Al Hail

    Citation: Systematic Reviews 2020 9:161

    Content type: Protocol

    Published on:

  27. Coronavirus disease 2019 (COVID-19) is a novel infectious viral disease, which lacks well-established diagnostic laboratory parameters that could be used to evaluate disease severity, thromboembolism or cardio...

    Authors: Changqian Bao, Xiandong Tao, Wei Cui, Bin Yi, Tiewen Pan, Ken H. Young and Wenbin Qian

    Citation: Experimental Hematology & Oncology 2020 9:16

    Content type: Research

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  28. Acute respiratory distress syndrome virus-2 (SARS-CoV-2) responsible for coronavirus disease 2019 (COVID-19) infection, which causes global public health emergencies, has sped widely for more than 5 months and...

    Authors: Hongbing Peng, Tiefeng Gong, Xiaoying Huang, Xun Sun, Hong Luo, Weizhong Wang, Junbiao Luo, Baowei Luo, Yanhui Chen, Xingxing Wang, Haifeng Long, Hua Mei, Chuang Li, Yanni Dai and Honghui Li

    Citation: Stem Cell Research & Therapy 2020 11:291

    Content type: Short report

    Published on:

  29. Since the first case of coronavirus disease 2019 (COVID-19) in Africa was detected on February 14, 2020, the cumulative confirmations reached 15 207 including 831 deaths by April 13, 2020. Africa has been desc...

    Authors: Salihu S. Musa, Shi Zhao, Maggie H. Wang, Abdurrazaq G. Habib, Umar T. Mustapha and Daihai He

    Citation: Infectious Diseases of Poverty 2020 9:96

    Content type: Research Article

    Published on:

  30. Coronavirus disease 2019 (COVID-19) has caused a serious epidemic around the world, but it has been effectively controlled in the mainland of China. The Chinese government limited the migration of people almos...

    Authors: Yong Li, Lian-Wen Wang, Zhi-Hang Peng and Hong-Bing Shen

    Citation: Infectious Diseases of Poverty 2020 9:94

    Content type: Research Article

    Published on:

  31. The world is facing a massive burden from the coronavirus disease 2019 (COVID-19) pandemic. Governments took the extraordinary step of locking down their own countries to curb the spread of the coronavirus. Af...

    Authors: Pier Luigi Ingrassia, Giorgio Capogna, Cristina Diaz-Navarro, Demian Szyld, Stefania Tomola and Esther Leon-Castelao

    Citation: Advances in Simulation 2020 5:13

    Content type: Debate article

    Published on:

  32. Severe acute respiratory syndrome (SARS)-CoV-2-induced coronavirus disease-2019 (COVID-19) is a pandemic disease that affects > 2.8 million people worldwide, with numbers increasing dramatically daily. However...

    Authors: Jincheng Xu, Xiaoyue Xu, Lina Jiang, Kamal Dua, Philip M. Hansbro and Gang Liu

    Citation: Respiratory Research 2020 21:182

    Content type: Research

    Published on:

  33. In December 2019, the outbreak of a disease subsequently termed COVID-19 occurred in Wuhan, China. The number of cases increased rapidly and spread to six continents. However, there is limited information on t...

    Authors: Jie Zhang, Guangping Meng, Wei Li, Bingqing Shi, Hongna Dong, Zhenzhong Su, Qian Huang and Peng Gao

    Citation: Respiratory Research 2020 21:180

    Content type: Research

    Published on:

  34. The COVID-19 pandemic, caused by SARS-CoV-2 virus, has resulted in over 100,000 deaths in the USA. Our institution has treated over 2000 COVID-19 patients during the pandemic in New York City. The pandemic dir...

    Authors: Bo Wang, Oliver Van Oekelen, Tarek H. Mouhieddine, Diane Marie Del Valle, Joshua Richter, Hearn Jay Cho, Shambavi Richard, Ajai Chari, Sacha Gnjatic, Miriam Merad, Sundar Jagannath, Samir Parekh and Deepu Madduri

    Citation: Journal of Hematology & Oncology 2020 13:94

    Content type: Research

    Published on:

  35. The COVID-19 pandemic is a complex global public health crisis presenting clinical, organisational and system-wide challenges. Different research perspectives on health are needed in order to manage and monito...

    Authors: D. Kringos, F. Carinci, E. Barbazza, V. Bos, K. Gilmore, O. Groene, L. Gulácsi, D. Ivankovic, T. Jansen, S. P. Johnsen, S. de Lusignan, J. Mainz, S. Nuti and N. Klazinga

    Citation: Health Research Policy and Systems 2020 18:80

    Content type: Commentary

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  36. Bacillus Calmette-Guérin (BCG) vaccination is routine and near-universal in many low- and middle-income countries (LMIC). It has been suggested that BCG can have a protective effect on COVID-19 morbidity and m...

    Authors: Marcos Pereira, Enny Paixão, Anete Trajman, Ramon Andrade de Souza, Marcio Santos da Natividade, Julia M. Pescarini, Susan Martins Pereira, Florisneide Rodrigues Barreto, Ricardo Ximenes, Margareth Dalcomo, Maria Yury Ichihara, Ceuci Nunes, Manoel Barral-Netto and Maurício L. Barreto

    Citation: Respiratory Research 2020 21:178

    Content type: Letter to the Editor

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  37. The recent outbreak by SARS-CoV-2 has generated a chaos in global health and economy and claimed/infected a large number of lives. Closely resembling with SARS CoV, the present strain has manifested exceptiona...

    Authors: Amrita Banerjee, Dipannita Santra and Smarajit Maiti

    Citation: Journal of Translational Medicine 2020 18:281

    Content type: Research

    Published on:

  38. Shenzhen is a city of 22 million people in south China that serves as a financial and trade center for East Asia. The city has extensive ties to Hubei Province, the first reported epicenter of the coronavirus ...

    Authors: Huachun Zou, Yuelong Shu and Tiejian Feng

    Citation: Infectious Diseases of Poverty 2020 9:89

    Content type: Commentary

    Published on:

  39. The new coronavirus disease COVID-19 began in December 2019 and has spread rapidly by human-to-human transmission. This study evaluated the transmissibility of the infectious disease and analyzed its associati...

    Authors: Xiao-Jing Guo, Hui Zhang and Yi-Ping Zeng

    Citation: Infectious Diseases of Poverty 2020 9:87

    Content type: Research Article

    Published on:

  40. The positive predictive effect of altruism on physical and psychological well-being has been extensively demonstrated in previous studies, but few studies have examined the effect of altruism on negative menta...

    Authors: Yi Feng, Min Zong, Zhizun Yang, Wen Gu, Dan Dong and Zhihong Qiao

    Citation: Globalization and Health 2020 16:61

    Content type: Research

    Published on:

  41. Severe acute respiratory syndrome (SARS) has been initiating pandemics since the beginning of the century. In December 2019, the world was hit again by a devastating SARS episode that has so far infected almos...

    Authors: Nitin Chitranshi, Vivek K. Gupta, Rashi Rajput, Angela Godinez, Kanishka Pushpitha, Ting Shen, Mehdi Mirzaei, Yuyi You, Devaraj Basavarajappa, Veer Gupta and Stuart L. Graham

    Citation: Journal of Translational Medicine 2020 18:278

    Content type: Research

    Published on:

  42. Coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) recently was declared a pandemic by world health organization (WHO) Due to sudden outbreaks, currently, no ...

    Authors: Shahid Hussain, Ya-Jia Xie, Dan Li, Shaukat Iqbal Malik, Jin-cai Hou, Elaine Lai-Han Leung and Xing-Xing Fan

    Citation: Chinese Medicine 2020 15:70

    Content type: Review

    Published on:

  43. Coronavirus Disease is impacting the entire world. As the first country that has needed to confront this disease, China has responded with unprecedented and hugely successful public health initiatives. Almost ...

    Authors: Shitao Chen, Feihan Li, Chaihua Lin, Yuge Han, Xilun Nie, Robert N. Portnoy and Zhihong Qiao

    Citation: Globalization and Health 2020 16:59

    Content type: Commentary

    Published on:

  44. The Coronavirus disease (COVID-19) is highly infectious, with the recent World Health Organization decree confirming a global public health emergency. The outcomes related to maternal and fetal health among pr...

    Authors: Juliana Vasconcellos Freitas-Jesus, Larissa Rodrigues and Fernanda Garanhani Surita

    Citation: Reproductive Health 2020 17:108

    Content type: Study protocol

    Published on: