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Coronavirus research highlights

A novel coronavirus, 2019-nCoV, has been identified as the cause of an outbreak of respiratory illness that originated in Wuhan, China, and which has spread to several other countries around the world.  Recent content from BMC and SpringerOpen journals relevant to coronavirus research, as well as additional commentary on this topic, is included below. 

BMC, as part of Springer Nature, encourages early sharing of research submitted to all our journals through preprints, and our In Review preprint service is available for many journals. We strongly urge authors submitting articles related to this emergency to BMC journals to share underlying interim and final research datasets relating to the outbreak as rapidly and widely as possible, including with public health and research communities and the WHO.

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  1. Dysregulation of transcription and cytokine expression has been implicated in the pathogenesis of a variety inflammatory diseases. The resulting imbalance between inflammatory and resolving transcriptional pro...

    Authors: Gregory Thomas, Elizabeth Frederick, Lisa Thompson, Raphael Bar-Or, Yetti Mulugeta, Melissa Hausburg, Michael Roshon, Charles Mains and David Bar-Or

    Citation: Journal of Translational Medicine 2020 18:452

    Content type: Research

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  2. During the coronavirus disease-2019 (COVID-19) pandemic, Italian hospitals faced the most daunting challenges of their recent history, and only essential therapeutic interventions were feasible. From March to ...

    Authors: Giuseppe Astori, Martina Bernardi, Angela Bozza, Daniela Catanzaro, Katia Chieregato, Anna Merlo, Monica Santimaria, Roberto Barbazza, Giuseppe Amodeo, Rachele Ciccocioppo, Francesca Elice and Marco Ruggeri

    Citation: Journal of Translational Medicine 2020 18:451

    Content type: Research

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  3. During the COVID-19 pandemic, most people had to cope with the restrictions of the lockdown, leaving them to their fears, insecurity and isolation. On the other hand, due to the unexpected ‘extra time’ there w...

    Authors: Arndt Büssing, Daniela Rodrigues Recchia, Rudolf Hein and Thomas Dienberg

    Citation: Health and Quality of Life Outcomes 2020 18:374

    Content type: Research

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  4. The COVID-19 pandemic has imposed an enormous burden on health care systems around the world. In the past, the administration of convalescent plasma of patients having recovered from SARS and severe influenza ...

    Authors: Timothy Devos, Tatjana Geukens, Alexander Schauvlieghe, Kevin K. Ariën, Cyril Barbezange, Myriam Cleeren, Veerle Compernolle, Nicolas Dauby, Daniël Desmecht, David Grimaldi, Bart N. Lambrecht, Anne Luyten, Piet Maes, Michel Moutschen, Marta Romano, Lucie Seyler…

    Citation: Trials 2020 21:981

    Content type: Study protocol

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  5. Currently, the world is in the seventh month of the COVID-19 pandemic. Globally, infections with novel SARS-CoV-2 virus are continuously rising with mounting numbers of deaths. International and local public h...

    Authors: Mitko Madjunkov, Michal Dviri and Clifford Librach

    Citation: Journal of Ovarian Research 2020 13:140

    Content type: Review

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  6. Since December 2019, the outbreak of coronavirus pneumonia was observed in China and quickly propagate in all of the world. Nowadays, many trials are underway on this disease in which the efficacy of various t...

    Authors: Maryam Azimi and Fatemeh Sadat Hasheminasab

    Citation: Trials 2020 21:978

    Content type: Study protocol

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  7. Previous studies have focused on the clinical characteristics of hospitalized patients with the novel 2019 coronavirus disease (COVID-19). Limited data are available for convalescent patients. This study aimed...

    Authors: Siqin Zhang, Lin Liu, Bin Yang, Rou Li, Jianhua Luo, Jing Huang, Yanjun Long, Ying Huang, Jianping Zhou, Yan Zha and Xiangyan Zhang

    Citation: Respiratory Research 2020 21:314

    Content type: Research

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  8. The clinical characteristics and outcomes of the 2019 novel coronavirus (COVID-19) pneumonia are different in Hubei compared to other regions in China. But there are few comparative studies on the differences ...

    Authors: Chang Wang, Lizhi Zhou, Juan Chen, Yong Yang, Tianlong Huang, Min Fu, Ya Li, Daniel M. George and Xiangyu Chen

    Citation: Respiratory Research 2020 21:313

    Content type: Research

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  9. On March 13, 2020, Uganda instituted COVID-19 symptom screening at its international airport, isolation and SARS-CoV-2 testing for symptomatic persons, and mandatory 14-day quarantine and testing of persons tr...

    Authors: Richard Migisha, Benon Kwesiga, Bernadette Basuta Mirembe, Geofrey Amanya, Steven N. Kabwama, Daniel Kadobera, Lilian Bulage, Godfrey Nsereko, Ignatius Wadunde, Tonny Tindyebwa, Bernard Lubwama, Atek A. Kagirita, John T. Kayiwa, Julius J. Lutwama, Amy L. Boore, Julie R. Harris…

    Citation: Globalization and Health 2020 16:114

    Content type: Research

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  10. The COVID-19 pandemic has the potential to cause high morbidity and mortality in crisis-affected populations. Delivering COVID-19 treatment services in crisis settings will likely entail complex trade-offs bet...

    Authors: Sylvia Garry, Nada Abdelmagid, Louisa Baxter, Natalie Roberts, Olivier le Polain de Waroux, Sharif Ismail, Ruwan Ratnayake, Caroline Favas, Elizabeth Lewis and Francesco Checchi

    Citation: Conflict and Health 2020 14:80

    Content type: Research in practice

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  11. Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) emerged from China in December 2019 and has presented as a substantial and serious threat to global health. We aimed to describe the clinical, epide...

    Authors: Abbas Al Mutair, Saad Alhumaid, Waad N. Alhuqbani, Abdul Rehman Z. Zaidi, Safug Alkoraisi, Maha F. Al-Subaie, Alanoud M. AlHindi, Ahmed K. Abogosh, Aljwhara K. Alrasheed, Aya A. Alsharafi, Mohammed N. Alhuqbani, Njoud A. Alhowar, Samer Salih, Mogbil A. Alhedaithy, Jaffar A. Al-Tawfiq, Haifa Al-Shammari…

    Citation: European Journal of Medical Research 2020 25:61

    Content type: Research

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  12. To assess the efficacy of ivermectin in addition to standard treatment compared to standard treatment alone in reducing hospitalizations in the COVID-19 patient population.

    Authors: Julio Vallejos, Rodrigo Zoni, Maria Bangher, Silvina Villamandos, Angelina Bobadilla, Fabian Plano, Claudia Campias, Evangelina Chaparro Campias, Fernando Achinelli, Hector A. Guglielmone, Jorge Ojeda, Fernanda Medina, Diego Farizano Salazar, Gerardo Andino, Natalia E. Ruiz Diaz, Pablo Kawerin…

    Citation: Trials 2020 21:965

    Content type: Letter

    Published on:

  13. Coronavirus disease COVID-19 has become a public health emergency of international concern. Together with the quest for an effective treatment, the question of the post-infectious evolution of affected patient...

    Authors: AN Frix, L. Schoneveld, A. Ladang, M. Henket, B. Duysinx, F. Vaillant, B. Misset, M. Moutschen, R. Louis, E. Cavalier and J. Guiot

    Citation: Respiratory Research 2020 21:309

    Content type: Letter to the Editor

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  14. Pharmacological therapies of proven efficacy in coronavirus disease 2019 (COVID-19) are still lacking. We have identified IFNβ-1a as the most promising drug to be repurposed for COVID-19. The rationale relies ...

    Authors: Emanuele Bosi, Carlo Bosi, Patrizia Rovere Querini, Nicasio Mancini, Giliola Calori, Annalisa Ruggeri, Cecilia Canzonieri, Luciano Callegaro, Massimo Clementi, Francesco De Cobelli, Massimo Filippi and Marco Bregni

    Citation: Trials 2020 21:939

    Content type: Study protocol

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  15. The Coronavirus Disease 2019 (COVID-19) pandemic may have altered emergency workflows established to optimize the outcome of patients with large-vessel occlusion (LVO) stroke.

    Authors: Steffen Tiedt, Felix J. Bode, Timo Uphaus, Anna Alegiani, Klaus Gröschel and Gabor C. Petzold

    Citation: Neurological Research and Practice 2020 2:44

    Content type: Research article

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  16. Flexor tendon injuries most commonly occur following a penetrating injury to the hand or wrist. These are challenging injuries and the standard treatment is surgical repair under general or regional anaesthesia.

    Authors: Grant S. Nolan, Ailbhe L. Kiely, Tomas Madura and Alexia Karantana

    Citation: Systematic Reviews 2020 9:264

    Content type: Protocol

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  17. The novel coronavirus disease (COVID-19) is posing a serious challenge to the health-care systems worldwide, with an enormous impact on health conditions and loss of lives. Notably, obesity and its related com...

    Authors: Antonio Paoli, Stefania Gorini and Massimiliano Caprio

    Citation: Journal of Translational Medicine 2020 18:441

    Content type: Review

    Published on:

  18. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes coronavirus disease 2019 (COVID-19) which has rapidly spread worldwide. Several human randomized clinical trials assessing potential vaccines...

    Authors: Steven Kwasi Korang, Sophie Juul, Emil Eik Nielsen, Joshua Feinberg, Faiza Siddiqui, Giok Ong, Sarah Klingenberg, Areti Angeliki Veroniki, Fanlong Bu, Lehana Thabane, Allan Randrup Thomsen, Janus C. Jakobsen and Christian Gluud

    Citation: Systematic Reviews 2020 9:262

    Content type: Protocol

    Published on:

  19. Welfare states around the world restrict access to public healthcare for some migrant groups. Formal restrictions on migrants’ healthcare access are often justified with economic arguments; for example, as a m...

    Authors: Nora Gottlieb, Ursula Trummer, Nadav Davidovitch, Allan Krasnik, Sol P. Juárez, Mikael Rostila, Louise Biddle and Kayvan Bozorgmehr

    Citation: Globalization and Health 2020 16:113

    Content type: Commentary

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  20. Zilucoplan (complement C5 inhibitor) has profound effects on inhibiting acute lung injury post COVID-19, and can promote lung repair mechanisms that lead to improvement in lung oxygenation parameters. The purp...

    Authors: Jozefien Declercq, Cedric Bosteels, Karel Van Damme, Elisabeth De Leeuw, Bastiaan Maes, Ans Vandecauter, Stefanie Vermeersch, Anja Delporte, Bénédicte Demeyere, Marnik Vuylsteke, Marianna Lalla, Trevor Smart, Laurent Detalle, René Bouw, Johannes Streffer, Thibo Degeeter…

    Citation: Trials 2020 21:934

    Content type: Letter

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  21. The last months have left no-one in doubt that the COVID-19 pandemic is exerting enormous pressure on health systems around the world, bringing to light the sub-optimal resilience of even those classified as h...

    Authors: Charbel El Bcheraoui, Heide Weishaar, Francisco Pozo-Martin and Johanna Hanefeld

    Citation: Globalization and Health 2020 16:112

    Content type: Commentary

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  22. Comparing health care parameters of acute ischemic stroke (AIS) patients with and without concurrent coronavirus disease 2019 (Covid-19, SARS-CoV-2 infection), may be helpful in terms of optimizing clinical an...

    Authors: Daniel Richter, Christos Krogias, Jens Eyding, Dirk Bartig, Armin Grau and Ralph Weber

    Citation: Neurological Research and Practice 2020 2:48

    Content type: Letter to the editor

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  23. In response to the COVID-19 epidemic, caused by a novel coronavirus, it was of great importance to rapidly collect as much accurate information as possible in order to characterize the public health threat and...

    Authors: Nina Van Goethem, Aline Vilain, Chloé Wyndham-Thomas, Jessika Deblonde, Nathalie Bossuyt, Tinne Lernout, Javiera Rebolledo Gonzalez, Sophie Quoilin, Vincent Melis and Dominique Van Beckhoven

    Citation: Archives of Public Health 2020 78:121

    Content type: Methodology

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  24. Early evidence indicates increased mental health burden arising from COVID-19 and related control measures. The study aim was to examine concern about COVID-19 and its association with symptoms of mental disor...

    Authors: Nino Makhashvili, Jana Darejan Javakhishvili, Lela Sturua, Ketevan Pilauri, Daniela C. Fuhr and Bayard Roberts

    Citation: Globalization and Health 2020 16:111

    Content type: Research

    Published on:

  25. Type 2 Diabetes Mellitus (T2DM) is a well-known comorbidity to COVID-19 and coagulopathies are a common accompaniment to both T2DM and COVID-19. In addition, patients with COVID-19 are known to develop micro-c...

    Authors: Etheresia Pretorius, Chantelle Venter, Gert Jacobus Laubscher, Petrus Johannes Lourens, Janami Steenkamp and Douglas B. Kell

    Citation: Cardiovascular Diabetology 2020 19:193

    Content type: Original investigation

    Published on:

  26. The COVID-19 pandemic led to the closure of the IDEA syringe services program medical student-run free clinic in Miami, Florida. In an effort to continue to serve the community of people who inject drugs and p...

    Authors: Marcus Castillo, Brianna Conte, Sam Hinkes, Megan Mathew, C. J. Na, Ainhoa Norindr, David P. Serota, David W. Forrest, Amar R. Deshpande, Tyler S. Bartholomew and Hansel E. Tookes

    Citation: Harm Reduction Journal 2020 17:88

    Content type: Brief report

    Published on:

  27. Investigating clinical characteristics of patients presenting with cerebrovascular events during the pandemic may provide valuable insight into further understanding the phenomenon of decreased stroke admissio...

    Authors: Carolin Hoyer, Lenja Weber, Vesile Sandikci, Anne Ebert, Michael Platten and Kristina Szabo

    Citation: Neurological Research and Practice 2020 2:47

    Content type: Letter to the editor

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  28. COVID-19, the illness caused by the SARS-CoV-2 virus, has reached pandemic proportions. Although the virus can cause disease in anyone, it is particularly dangerous for those with various “co-morbidities” such...

    Authors: A. Mark Clarfield and Alan Jotkowitz

    Citation: Israel Journal of Health Policy Research 2020 9:64

    Content type: Perspective

    Published on:

  29. Only one in four people with eating disorders seeks treatment, and of those who do seek treatment, 20% go on to experience a chronic course. Early intervention has been associated with better prognosis, with t...

    Authors: Emma Bryant, Jane Miskovic-Wheatley, Stephen Touyz, Ross D. Crosby, Eyza Koreshe, Li Cao and Sarah Maguire

    Citation: Journal of Eating Disorders 2020 8:60

    Content type: Study protocol

    Published on:

  30. Prior to the COVID-19 pandemic, 44% of all reported injuries in U.S. households occurred in the home. Spending more time at home due to the pandemic may increase the number of home injuries.

    Authors: Andrea C. Gielen, Grace Bachman, Oluwakemi Badaki-Makun, Renee M. Johnson, Eileen McDonald, Elise Omaki, Keshia M. Pollack Porter, Leticia Ryan and Wendy Shields

    Citation: Injury Epidemiology 2020 7:63

    Content type: Short Report

    Published on:

  31. At present, “severe acute respiratory syndrome new coronavirus” (SARS-CoV-2) affects the whole world and has led to a pandemia with almost 2.000.000 infected patients in the mid of April 2020 (WHO). Thus, heal...

    Authors: Christian Urbanek, Jana Kötteritzsch, Wolfgang Zink and Armin J. Grau

    Citation: Neurological Research and Practice 2020 2:32

    Content type: Research article

    Published on:

  32. Several recent studies suggest the possibility of a skin rash being a clinical presentation of coronavirus disease 2019 (COVID-19). The purpose of this case report is to bring attention to skin manifestations ...

    Authors: Alice Serafini, Peter Konstantin Kurotschka, Mariabeatrice Bertolani and Silvia Riccomi

    Citation: Journal of Medical Case Reports 2020 14:216

    Content type: Case report

    Published on:

  33. On December 12, 2019 a new coronavirus (SARS-CoV-2) emerged in Wuhan, China, triggering a pandemic of severe acute respiratory syndrome in humans (COVID-19). Today, the scientific community is investing all th...

    Authors: Laura Di Renzo, Paola Gualtieri, Francesca Pivari, Laura Soldati, Alda Attinà, Claudia Leggeri, Giulia Cinelli, Maria Grazia Tarsitano, Giovanna Caparello, Elena Carrano, Giuseppe Merra, Alberto Maria Pujia, Roberta Danieli and Antonino De Lorenzo

    Citation: Journal of Translational Medicine 2020 18:415

    Content type: Review

    Published on:

  34. Previous studies on the impact of corona virus disease 2019 (COVID-19) on the mental health of the patients has been limited by the lack of relevant data. With the rapid and sustained growth of the publication...

    Authors: Jiyuan Shi, Ya Gao, Liang Zhao, Yuanyuan Li, Meili Yan, Ming Ming Niu, Yamin Chen, Ziwei Song, Ruixing Zhang, Lili Zhang and Jinhui Tian

    Citation: Systematic Reviews 2020 9:258

    Content type: Protocol

    Published on:

  35. Since the birth of Christ, in these 2019 years, the man on earth has never experienced a survival challenge from any acellular protist compared to SARS-CoV-2. No specific drugs yet been approved. The host immu...

    Authors: Kishalay Paria, Debarati Paul, Trinath Chowdhury, Smritikana Pyne, Ranadhir Chakraborty and Santi M. Mandal

    Citation: Translational Medicine Communications 2020 5:21

    Content type: Review

    Published on:

  36. The COVID-19 pandemic has created a sense of urgency in the research community in their bid to contribute to the evidence required for healthcare policy decisions. With such urgency, researchers experience met...

    Authors: Linda Biesty, Pauline Meskell, Claire Glenton, Hannah Delaney, Mike Smalle, Andrew Booth, Xin Hui S. Chan, Declan Devane and Catherine Houghton

    Citation: Systematic Reviews 2020 9:256

    Content type: Methodology

    Published on:

  37. Since the World Health Organization declared a global pandemic due to the novel coronavirus disease2019, there have been targeted efforts to establish management modalities. Hydroxychloroquine has been suggest...

    Authors: Ivorie Coleman, Gabriel Ruiz, Sumir Brahmbhatt and Lindsay Ackerman

    Citation: Journal of Medical Case Reports 2020 14:210

    Content type: Case report

    Published on:

  38. - To describe the evolution of the SARS-CoV-2 salivary viral load of patients infected with Covid-19, performing 7 days of tri-daily mouthwashes with and without antivirals.

    Authors: Florence Carrouel, Stéphane Viennot, Martine Valette, Jean-Marie Cohen, Claude Dussart and Denis Bourgeois

    Citation: Trials 2020 21:906

    Content type: Letter

    Published on:

  39. The SARS-CoV-2 RNA was detected positive again after discharged from hospital in some COVID-19 patients, with or without clinical symptoms such as fever or dry cough.

    Authors: Yongqing Tong, Anyu Bao, Hongbing Chen, Jingtao Huang, Zhihua Lv, Lina Feng, Yun Cheng, Youna Wang, Li Bai, Wenlong Rao, Hongyun Zheng, Zegang Wu, Bin Qiao, Zhijun Zhao, Huiming Wang and Yan Li

    Citation: Journal of Translational Medicine 2020 18:411

    Content type: Research

    Published on:

  40. Israel hosts nearly 70,000 migrant careworkers. Migrant careworkers work and live with populations extremely vulnerable to the novel Coronavirus, including the elderly and people with pre-existing physical con...

    Authors: Jordan Hannink Attal, Ido Lurie and Yehuda Neumark

    Citation: Israel Journal of Health Policy Research 2020 9:61

    Content type: Original research article

    Published on:

  41. Lockdown implemented to prevent the COVID-19 spread resulted in marked changes in the lifestyle. The objective of the current study was to assess the impact of lockdown measures on a cohort of eating disorder ...

    Authors: Paulo P. P. Machado, Ana Pinto-Bastos, Rita Ramos, Tânia F. Rodrigues, Elsa Louro, Sónia Gonçalves, Isabel Brandão and Ana Vaz

    Citation: Journal of Eating Disorders 2020 8:57

    Content type: Research article

    Published on:

  42. COronaVIrus Disease 19 (COVID-19) is caused by the infection of the Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV-2). Although the main clinical manifestations of COVID-19 are respiratory, many pat...

    Authors: S. Greco, A. Madè, C. Gaetano, Y. Devaux, C. Emanueli and F. Martelli

    Citation: Journal of Translational Medicine 2020 18:408

    Content type: Review

    Published on:

  43. The use of telemedicine in pediatric rheumatology has been historically low. The current COVID 19 global pandemic has forced a paradigm shift with many centers rapidly adopting virtual visits to conduct care r...

    Authors: Susan Shenoi, Kristen Hayward, Megan L. Curran, Elizabeth Kessler, Jay J. Mehta, Meredith P. Riebschleger and Helen E. Foster

    Citation: Pediatric Rheumatology 2020 18:85

    Content type: Commentary

    Published on:

  44. It has been recently hypothesized that infection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may lead to fibrotic sequelae in patients recovering from coronavirus disease 2019 (COVID-19). I...

    Authors: Paola Rogliani, Luigino Calzetta, Angelo Coppola, Ermanno Puxeddu, Gianluigi Sergiacomi, Dejanira D’Amato and Antonio Orlacchio

    Citation: Respiratory Research 2020 21:286

    Content type: Letter to the Editor

    Published on:

  45. Israel ranks very high globally in performing bariatric surgery (BS) per capita. In the first phase of the COVID-19 pandemic the bariatric surgeons’ community faced many concerns and challenges, especially in ...

    Authors: Nahum Beglaibter, Orly Zelekha, Lital Keinan-Boker, Nasser Sakran and Ahmad Mahajna

    Citation: Israel Journal of Health Policy Research 2020 9:59

    Content type: Original research article

    Published on: