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Emerging concepts in neurodegenerative diseases

Alzheimer’s disease, Parkinson’s disease and Huntington’s disease are debilitating neurodegenerative disorders with great unmet medical needs. Although these diseases affect different areas of the brain and have distinct clinical presentations, they are all marked by the aggregation of misfolded proteins. Aided by the recent biological and technical advancement, much progress has been made on understanding the genetic, molecular and neuropathological underpinnings. While neuronal dysfunction and loss dictate the clinical symptoms, it is now appreciated that other cell types, such as astrocytes, microglia, oligodendrocytes, cells of the vascular system and, indeed, peripheral immune cells, also play important roles at various stages of the disease process. Thus, a hypothesis is emerging that these diseases are systemic disorders, and may be impacted by malfunction of central and peripheral tissues or organs. Further investigation of the cell-intrinsic mechanisms and cell-cell communications will undoubtedly facilitate a deeper understanding of the disease pathogenesis and identification of new targets for therapeutic intervention.
This series new addresses various aspects of neurodegenerative diseases including, but not limited to:

  • Intracellular trafficking and signaling pathways
  • Neuron-glia interactions 
  • Innate immunity and neuroinflammation
  • Role of the blood-brain barrier and vascular system
  • Role of peripheral immune cells
  • Influence of aging in age-related neurodegenerative diseases

Series Editors: 
Hui Zheng, Baylor College of Medicine
Lin Mei, Case Western Reserve University

  1. Tau protein forms neurofibrillary tangles and becomes deposited in the brain during Alzheimer’s disease (AD). Tau oligomers are the most reactive species, mediating neurotoxic and inflammatory activity. Microg...

    Authors: Subashchandrabose Chinnathambi and Rashmi Das
    Citation: Cell & Bioscience 2023 13:95
  2. The dynamic changes in chromatin conformation alter the organization and structure of the genome and further regulate gene transcription. Basically, the chromatin structure is controlled by reversible, enzyme-...

    Authors: Dongfang Jiang, Tingting Li, Caixia Guo, Tie-Shan Tang and Hongmei Liu
    Citation: Cell & Bioscience 2023 13:10
  3. Temporal lobe epilepsy (TLE) remains one of the most drug-resistant focal epilepsies. Glutamate excitotoxicity and neuroinflammation which leads to loss of synaptic proteins and neuronal death appear to repres...

    Authors: Namgue Hong, Hee Jung Kim, Keunsoo Kang, Ji On Park, Seyoung Mun, Hyung-Gun Kim, Bong Hui Kang, Phil-Sang Chung, Min Young Lee and Jin-Chul Ahn
    Citation: Cell & Bioscience 2023 13:8
  4. Krüppel-like factor 7 (klf7), a transcription factor in the nervous system to regulate cell proliferation and differentiation, has been recently identified as a causal gene for autism spectrum disorder (ASD), ...

    Authors: Hui Tian, Yanwen Jiao, Mingyue Guo, Yilin Wang, Ruiqi Wang, Cao Wang, Xiongbiao Chen and Weiming Tian
    Citation: Cell & Bioscience 2022 12:166
  5. Immune checkpoints are a set of costimulatory and inhibitory molecules that maintain self-tolerance and regulate immune homeostasis. The expression of immune checkpoints on T cells in malignancy, chronic infla...

    Authors: Ching-Tse Wu, Cheng-I Chu, Feng-Yu Wang, Hui-Yu Yang, Wei-Sung Tseng, Chuang-Rung Chang and Chien-Chung Chang
    Citation: Cell & Bioscience 2022 12:162
  6. The mammalian target of rapamycin (mTOR) plays a critical role in controlling cellular homeostasis, and its dysregulation has been implicated in Alzheimer’s disease (AD). Presenilin-1 (PS1) mutations account f...

    Authors: Cheong-Meng Chong, Yuan Tan, Jiaqi Tong, Minjing Ke, Ke Zhang, Lingli Yan, Xiaotong Cen, Jia-Hong Lu, Guobing Chen, Huanxing Su and Dajiang Qin
    Citation: Cell & Bioscience 2022 12:131
  7. The importance of neuroglia in maintaining normal brain function under physiological and pathological conditions has been supported by growing evidence in recent years. The most important issues regarding glia...

    Authors: Danying Yang, Xifeng Wang, Lieliang Zhang, Yang Fang, Qingcui Zheng, Xing Liu, Wen Yu, Shoulin Chen, Jun Ying and Fuzhou Hua
    Citation: Cell & Bioscience 2022 12:106
  8. Parkinson’s Disease (PD) is the second most frequent degenerative disorder, the risk of which increases with age. A preclinical PD diagnostic test does not exist. We identify PD blood metabolites and metabolic...

    Authors: Nicola D’Ascenzo, Emanuele Antonecchia, Antonella Angiolillo, Victor Bender, Marco Camerlenghi, Qingguo Xie and Alfonso Di Costanzo
    Citation: Cell & Bioscience 2022 12:102
  9. Huntington’s disease (HD) is a neurodegenerative disorder whereby mutated huntingtin protein (mHTT) aggregates when polyglutamine repeats in the N-terminal of mHTT exceeds 36 glutamines (Q). However, the mecha...

    Authors: Ewelina Latoszek, Małgorzata Wiweger, Jan Ludwiczak, Stanisław Dunin-Horkawicz, Jacek Kuznicki and Magdalena Czeredys
    Citation: Cell & Bioscience 2022 12:34
  10. Despite accumulating epidemiological studies support that diabetes increases the risk of Alzheimer’s disease (AD), the causal associations between diabetes and AD remain inconclusive. The present study aimed t...

    Authors: Lei Meng, Zhe Wang, Hong-Fang Ji and Liang Shen
    Citation: Cell & Bioscience 2022 12:28
  11. Previously, we collected age-stratified incidence data of 404 epidemiological datasets of 10 neurodegenerative diseases (NDs), namely Amyotrophic Lateral Sclerosis (ALS), Alzheimer’s disease (AD), Parkinson’s ...

    Authors: Daniela Gerovska and Marcos J. Araúzo-Bravo
    Citation: Cell & Bioscience 2022 12:11
  12. Autophagy is a cell self-digestion pathway through lysosome and plays a critical role in maintaining cellular homeostasis and cytoprotection. Characterization of autophagy related genes in cell and animal mode...

    Authors: Zhiqiang Deng, Xiaoting Zhou, Jia-Hong Lu and Zhenyu Yue
    Citation: Cell & Bioscience 2021 11:214
  13. Changes in soluble amyloid-beta (Aβ) levels in cerebrospinal fluid (CSF) are detectable at early preclinical stages of Alzheimer’s disease (AD). However, whether Aβ levels can predict downstream AD pathologica...

    Authors: Guilherme Povala, Bruna Bellaver, Marco Antônio De Bastiani, Wagner S. Brum, Pamela C. L. Ferreira, Andrei Bieger, Tharick A. Pascoal, Andrea L. Benedet, Diogo O. Souza, Ricardo M. Araujo, Bruno Zatt, Pedro Rosa-Neto and Eduardo R. Zimmer
    Citation: Cell & Bioscience 2021 11:204
  14. Dementia with Lewy bodies (DLB) is epitomized by the pathognomonic manifestation of α-synuclein-laden Lewy bodies within selectively vulnerable neurons in the brain. By virtue of prion-like inheritance, the α-...

    Authors: Christopher Simon, Tomoko Soga, Hirotaka James Okano and Ishwar Parhar
    Citation: Cell & Bioscience 2021 11:196
  15. Patients with Parkinson’s disease (PD) exhibit systemic deficits, including arthritis and osteoporosis-like symptoms. However, the questions, how the deficits in periphery organs or tissues occur in PD patient...

    Authors: Lei Xiong, Jin-Xiu Pan, Hao-han Guo, Lin Mei and Wen-Cheng Xiong
    Citation: Cell & Bioscience 2021 11:190
  16. During the last decades, numerous basic and clinical studies have been conducted to assess the delivery efficiency of therapeutic agents into the brain and spinal cord parenchyma using several administration r...

    Authors: Gozal Bahlakeh, Reza Rahbarghazi, Daruosh Mohammadnejad, Ali Abedelahi and Mohammad Karimipour
    Citation: Cell & Bioscience 2021 11:181
  17. Nowadays, a large population around the world, especially the elderly, suffers from neurological inflammatory and degenerative disorders/diseases. Current drug delivery strategies are facing different challeng...

    Authors: Morteza Heidarzadeh, Yasemin Gürsoy-Özdemir, Mehmet Kaya, Aysan Eslami Abriz, Amir Zarebkohan, Reza Rahbarghazi and Emel Sokullu
    Citation: Cell & Bioscience 2021 11:142