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Commentaries

This list will be updated with all of our new commentaries including Comments, Editorials, Meeting reports, Opinions and Q&As. Commentaries in Genome Medicine are open access and therefore free to read and share.

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  1. The cause of a complex disease cannot be pinpointed to a single origin; rather, a highly complex network of many factors that interact on different levels over time and space is disturbed. This complexity requ...

    Authors: Marc Kirschner, Angela Bauch, Alvar Agusti, Sebastian Hilke, Sibylle Merk, Christophe Pison, Jim Roldan, Bernard Seidenath, Michael Wilken, Emiel F. Wouters, Hans-Werner Mewes, Klaus Heumann and Dieter Maier
    Citation: Genome Medicine 2015 7:102
  2. New methods for epigenome editing now make it possible to manipulate the epigenome in living cells with unprecedented specificity and efficiency. These ground-breaking approaches are beginning to yield novel i...

    Authors: Anna Köferle, Stefan H. Stricker and Stephan Beck
    Citation: Genome Medicine 2015 7:59

    The Erratum to this article has been published in Genome Medicine 2015 7:75

  3. Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehens...

    Authors: Sebastian Schuol, Christoph Schickhardt, Stefan Wiemann, Claus R. Bartram, Klaus Tanner, Roland Eils, Benjamin Meder, Daniela Richter, Hanno Glimm, Christof von Kalle and Eva C. Winkler
    Citation: Genome Medicine 2015 7:83
  4. Expanded genetic carrier testing is changing clinical practice. Current experience highlights the need for rigorous curation of tens of thousands of variants as to their pathogenicity and phenotypic effects. T...

    Authors: Arthur L. Beaudet
    Citation: Genome Medicine 2015 7:79
  5. There are many challenges and opportunities for Africans in the emerging area of genome medicine. In particular, there is a need for investment in local education using real-world African genetic data sets. Cl...

    Authors: Geoffrey H Siwo, Scott M Williams and Jason H Moore
    Citation: Genome Medicine 2015 7:47

    The Erratum to this article has been published in Genome Medicine 2015 7:70

  6. Three-dimensional organotypic culture models show great promise as a tool for cancer precision medicine, with potential applications for oncogene modeling, gene discovery and chemosensitivity studies.

    Authors: Michael A Cantrell and Calvin J Kuo
    Citation: Genome Medicine 2015 7:32
  7. Microbiome-based therapies are moving quickly towards the clinic, with successes including fecal microbial transplants for recurring Clostridium difficile, hints of new antibiotics to come, and possible new micro...

    Authors: Fergus Shanahan
    Citation: Genome Medicine 2015 7:17
  8. Failure to consider lessons from behavioral economics in the case of whole genome sequencing may cause us to run into the ‘last mile problem’ - the failure to integrate newly developed technology, on which bil...

    Authors: Jennifer S Blumenthal-Barby, Amy L McGuire, Robert C Green and Peter A Ubel
    Citation: Genome Medicine 2015 7:3