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Commentaries

This list will be updated with all of our new commentaries including Comments, Editorials, Meeting reports, Opinions and Q&As. Commentaries in Genome Medicine are open access and therefore free to read and share.

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  1. Biomedical research is becoming increasingly large-scale and international. Cloud computing enables the comprehensive integration of genomic and clinical data, and the global sharing and collaborative processi...

    Authors: Fruzsina Molnár-Gábor, Rupert Lueck, Sergei Yakneen and Jan O. Korbel

    Citation: Genome Medicine 2017 9:58

    Content type: Opinion

    Published on:

  2. Recent advances in genome sequencing of single microbial cells enable the assignment of functional roles to members of the human microbiome that cannot currently be cultured. This approach can reveal the genom...

    Authors: Andrew C. Tolonen and Ramnik J. Xavier

    Citation: Genome Medicine 2017 9:56

    Content type: Comment

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  3. Recent advances in β-cell regeneration in vivo are providing insights into the mechanisms involved in the conversion of distinct pancreatic cell lineages into β cells. These mechanisms mostly involve reactivat...

    Authors: Solomon Afelik and Meritxell Rovira

    Citation: Genome Medicine 2017 9:42

    Content type: Comment

    Published on:

    The Erratum to this article has been published in Genome Medicine 2017 9:52

  4. Combinations of therapies are being actively pursued to expand therapeutic options and deal with cancer’s pervasive resistance to treatment. Research efforts to discover effective combination treatments have f...

    Authors: Jonathan R. Dry, Mi Yang and Julio Saez-Rodriguez

    Citation: Genome Medicine 2016 8:125

    Content type: Opinion

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  5. Precision medicine (PM) can be defined as a predictive, preventive, personalized, and participatory healthcare service delivery model. Recent developments in molecular biology and information technology make P...

    Authors: Gabrielle Bertier, Jian Carrot-Zhang, Vassilis Ragoussis and Yann Joly

    Citation: Genome Medicine 2016 8:108

    Content type: Opinion

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  6. Advances in genetic analysis have revealed new complexities in the interpretation of genetic variants. Correct assessment of a genetic variant relies on the clinical context and knowledge of the underlying bio...

    Authors: Eric Q. Konnick and Colin C. Pritchard

    Citation: Genome Medicine 2016 8:100

    Content type: Comment

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  7. The World Health Organization has declared Zika virus an international public health emergency. Knowledge of Zika virus genomic epidemiology is currently limited due to challenges in obtaining and processing s...

    Authors: Nuno Rodrigues Faria, Ester C. Sabino, Marcio R. T. Nunes, Luiz Carlos Junior Alcantara, Nicholas J. Loman and Oliver G. Pybus

    Citation: Genome Medicine 2016 8:97

    Content type: Comment

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  8. Medicine and healthcare are undergoing profound changes. Whole-genome sequencing and high-resolution imaging technologies are key drivers of this rapid and crucial transformation. Technological innovation comb...

    Authors: Charles Auffray, Rudi Balling, Inês Barroso, László Bencze, Mikael Benson, Jay Bergeron, Enrique Bernal-Delgado, Niklas Blomberg, Christoph Bock, Ana Conesa, Susanna Del Signore, Christophe Delogne, Peter Devilee, Alberto Di Meglio, Marinus Eijkemans, Paul Flicek…

    Citation: Genome Medicine 2016 8:71

    Content type: Opinion

    Published on:

    The Erratum to this article has been published in Genome Medicine 2016 8:118

  9. The identification of somatic mosaicism in the brain lends a new perspective to our understanding of the role of gene and environment interactions in psychiatric disease risk. Somatic mutations, such as retrot...

    Authors: Tracy A. Bedrosian, Sara Linker and Fred H. Gage

    Citation: Genome Medicine 2016 8:58

    Content type: Comment

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  10. There is a growing realization that the gut–brain axis plays a key role in maintaining brain health and the stress response. Recently, the gut microbiota has emerged as a master regulator of this axis. Thus, o...

    Authors: Timothy G. Dinan and John F. Cryan

    Citation: Genome Medicine 2016 8:36

    Content type: Comment

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  11. Management, manipulation, and restoration of a robust vaginal microbiota has the potential to vastly improve women’s health and disease prevention. However, a systems level understanding of how the vaginal mic...

    Authors: Jacques Ravel and Rebecca M. Brotman

    Citation: Genome Medicine 2016 8:35

    Content type: Comment

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  12. The cause of a complex disease cannot be pinpointed to a single origin; rather, a highly complex network of many factors that interact on different levels over time and space is disturbed. This complexity requ...

    Authors: Marc Kirschner, Angela Bauch, Alvar Agusti, Sebastian Hilke, Sibylle Merk, Christophe Pison, Jim Roldan, Bernard Seidenath, Michael Wilken, Emiel F. Wouters, Hans-Werner Mewes, Klaus Heumann and Dieter Maier

    Citation: Genome Medicine 2015 7:102

    Content type: Comment

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  13. New methods for epigenome editing now make it possible to manipulate the epigenome in living cells with unprecedented specificity and efficiency. These ground-breaking approaches are beginning to yield novel i...

    Authors: Anna Köferle, Stefan H. Stricker and Stephan Beck

    Citation: Genome Medicine 2015 7:59

    Content type: Comment

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    The Erratum to this article has been published in Genome Medicine 2015 7:75

  14. Incidental findings are the subject of intense ethical debate in medical genomic research. Every human genome contains a number of potentially disease-causing alterations that may be detected during comprehens...

    Authors: Sebastian Schuol, Christoph Schickhardt, Stefan Wiemann, Claus R. Bartram, Klaus Tanner, Roland Eils, Benjamin Meder, Daniela Richter, Hanno Glimm, Christof von Kalle and Eva C. Winkler

    Citation: Genome Medicine 2015 7:83

    Content type: Opinion

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  15. Expanded genetic carrier testing is changing clinical practice. Current experience highlights the need for rigorous curation of tens of thousands of variants as to their pathogenicity and phenotypic effects. T...

    Authors: Arthur L. Beaudet

    Citation: Genome Medicine 2015 7:79

    Content type: Comment

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  16. There are many challenges and opportunities for Africans in the emerging area of genome medicine. In particular, there is a need for investment in local education using real-world African genetic data sets. Cl...

    Authors: Geoffrey H Siwo, Scott M Williams and Jason H Moore

    Citation: Genome Medicine 2015 7:47

    Content type: Comment

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    The Erratum to this article has been published in Genome Medicine 2015 7:70

  17. Three-dimensional organotypic culture models show great promise as a tool for cancer precision medicine, with potential applications for oncogene modeling, gene discovery and chemosensitivity studies.

    Authors: Michael A Cantrell and Calvin J Kuo

    Citation: Genome Medicine 2015 7:32

    Content type: Comment

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  18. Microbiome-based therapies are moving quickly towards the clinic, with successes including fecal microbial transplants for recurring Clostridium difficile, hints of new antibiotics to come, and possible new micro...

    Authors: Fergus Shanahan

    Citation: Genome Medicine 2015 7:17

    Content type: Comment

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  19. Failure to consider lessons from behavioral economics in the case of whole genome sequencing may cause us to run into the ‘last mile problem’ - the failure to integrate newly developed technology, on which bil...

    Authors: Jennifer S Blumenthal-Barby, Amy L McGuire, Robert C Green and Peter A Ubel

    Citation: Genome Medicine 2015 7:3

    Content type: Comment

    Published on: