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Commentaries

Recent commentaries published in Genome Biology

This list will be updated with all of our new commentaries including Comments, Editorials, Meeting reports, Opinions and Q&As. Commentaries in Genome Biology are open access and therefore free to read and share.

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  1. The use of the human reference genome has shaped methods and data across modern genomics. This has offered many benefits while creating a few constraints. In the following opinion, we outline the history, prop...

    Authors: Sara Ballouz, Alexander Dobin and Jesse A. Gillis
    Citation: Genome Biology 2019 20:159
  2. Genetic, transcriptional, and post-transcriptional variations shape the transcriptome of individual cells, rendering establishing an exhaustive set of reference RNAs a complicated matter. Current reference tra...

    Authors: Antonin Morillon and Daniel Gautheret
    Citation: Genome Biology 2019 20:112
  3. Data science allows the extraction of practical insights from large-scale data. Here, we contextualize it as an umbrella term, encompassing several disparate subdomains. We focus on how genomics fits as a spec...

    Authors: Fábio C. P. Navarro, Hussein Mohsen, Chengfei Yan, Shantao Li, Mengting Gu, William Meyerson and Mark Gerstein
    Citation: Genome Biology 2019 20:109
  4. Machine learning has demonstrated potential in analyzing large, complex biological data. In practice, however, biological information is required in addition to machine learning for successful application.

    Authors: Chunming Xu and Scott A. Jackson
    Citation: Genome Biology 2019 20:76
  5. We polled the Editorial Board of Genome Biology to ask where they see genomics going in the next few years. Here are some of their responses.

    Authors: Barbara Cheifet
    Citation: Genome Biology 2019 20:17
  6. As part of our Q&A series, Genome Biology spoke to four scientists about their personal experiences as parents in their careers to highlight the challenges of researchers having children and the support they need...

    Authors: Emily Perry, Kristin Tessmar-Raible and Florian Raible
    Citation: Genome Biology 2018 19:180
  7. A meeting report on the 14th Gordon Research Conference on Meiosis, held at Colby Sawyer College, New London, NH, USA, 9–15 June 2018, chaired by Monica Colaiacovo, Harvard Medical School.

    Authors: Weronika E. Borek and Adele L. Marston
    Citation: Genome Biology 2018 19:134
  8. The recent shift of computational biologists from bioinformatics service providers to leaders of cutting-edge programs highlights the accompanying cultural and conceptual changes that should be implemented by ...

    Authors: Itai Yanai and Eva Chmielnicki
    Citation: Genome Biology 2017 18:223
  9. Open Science is encouraged by the European Union and many other political and scientific institutions. However, scientific practice is proving slow to change. We propose, as early career researchers, that it i...

    Authors: Andrea Farnham, Christoph Kurz, Mehmet Ali Öztürk, Monica Solbiati, Oona Myllyntaus, Jordy Meekes, Tra My Pham, Clara Paz, Magda Langiewicz, Sophie Andrews, Liisa Kanninen, Chantal Agbemabiese, Arzu Tugce Guler, Jeffrey Durieux, Sarah Jasim, Olivia Viessmann…
    Citation: Genome Biology 2017 18:221
  10. In the second of our series of articles celebrating peer reviewers, we talk to Robert Lowe, who is a Lecturer in computational biology at Queen Mary University of London, UK, and a valued reviewer for Genome Biol...

    Authors: Robert Lowe
    Citation: Genome Biology 2017 18:72
  11. Supplements are increasingly important to the scientific record, particularly in genomics. However, they are often underutilized. Optimally, supplements should make results findable, accessible, interoperable,...

    Authors: Dov Greenbaum, Joel Rozowsky, Victoria Stodden and Mark Gerstein
    Citation: Genome Biology 2017 18:64
  12. Continuing with our Q&A series discussing issues of diversity in STEM fields, Genome Biology spoke with three openly LGBT+ researchers on their experiences in biology.

    Authors: Ben Barres, Beth Montague-Hellen and Jeremy Yoder
    Citation: Genome Biology 2017 18:62
  13. We summarize the remarkable progress that has been made in the identification and functional characterization of DNA sequence variants associated with disease.

    Authors: Mark I. McCarthy and Daniel G. MacArthur
    Citation: Genome Biology 2017 18:20
  14. A report on the Genome Informatics conference, held at the Wellcome Genome Campus Conference Centre, Hinxton, United Kingdom, 19–22 September 2016.

    Authors: Davide Chicco and Michael M. Hoffman
    Citation: Genome Biology 2017 18:5
  15. Nanopore DNA strand sequencing has emerged as a competitive, portable technology. Reads exceeding 150 kilobases have been achieved, as have in-field detection and analysis of clinical pathogens. We summarize k...

    Authors: Miten Jain, Hugh E. Olsen, Benedict Paten and Mark Akeson
    Citation: Genome Biology 2016 17:239

    The Erratum to this article has been published in Genome Biology 2016 17:256

  16. Studies of human genetic disorders have traditionally followed a reductionist paradigm. Traits are defined as Mendelian or complex based on family pedigree and population data, whereas alleles are deemed rare,...

    Authors: Nicholas Katsanis
    Citation: Genome Biology 2016 17:233
  17. Peer reviewers are the unsung heroes of science. We celebrate reviewers through a series of interviews with people who have made particularly strong recent contributions to Genome Biology as reviewers. The first ...

    Authors: Hyongbum Kim
    Citation: Genome Biology 2016 17:200
  18. The spreadsheet software Microsoft Excel, when used with default settings, is known to convert gene names to dates and floating-point numbers. A programmatic scan of leading genomics journals reveals that appr...

    Authors: Mark Ziemann, Yotam Eren and Assam El-Osta
    Citation: Genome Biology 2016 17:177
  19. Emerging single-cell epigenomic methods are being developed with the exciting potential to transform our knowledge of gene regulation. Here we review available techniques and future possibilities, arguing that...

    Authors: Stephen J. Clark, Heather J. Lee, Sébastien A. Smallwood, Gavin Kelsey and Wolf Reik
    Citation: Genome Biology 2016 17:72
  20. Single-cell transcriptomics has been employed in a growing number of animal studies, but the technique has yet to be widely used in plants. Nonetheless, early studies indicate that single-cell RNA-seq protocol...

    Authors: Idan Efroni and Kenneth D. Birnbaum
    Citation: Genome Biology 2016 17:65
  21. As the cost of sequencing continues to decrease and the amount of sequence data generated grows, new paradigms for data storage and analysis are increasingly important. The relative scaling behavior of these e...

    Authors: Paul Muir, Shantao Li, Shaoke Lou, Daifeng Wang, Daniel J Spakowicz, Leonidas Salichos, Jing Zhang, George M. Weinstock, Farren Isaacs, Joel Rozowsky and Mark Gerstein
    Citation: Genome Biology 2016 17:53

    The Erratum to this article has been published in Genome Biology 2016 17:78

  22. A report on the first EMBO conference entitled “Next Gen Immunology—From Host Genome to the Microbiome: Immunity in the Genomic Era”, held at the Weizmann Institute of Science, Israel, 14–16 February, 2016.

    Authors: David Zeevi, Tal Korem and Eran Segal
    Citation: Genome Biology 2016 17:50