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Overcoming Publication Bias in Clinical Trials

An article collection published in Journal of Negative Results in BioMedicine.

Clinical trials are one of our most valuable types of research for identifying cause-and-effect in regards to healthcare interventions. Publication of all clinical trial results, regardless of outcome or significance of findings, is not only an ethical responsibility but also enables the efficacy of interventions to be validated, while preventing undue risk to patients and waste of resources.

This special article collection brings together null and non-confirmatory results from randomized controlled trials that have been published in Journal of Negative Results in BioMedicine. With this article collection we celebrate those authors who support completing the published record and call for others to submit their null and non-confirmatory results to the journal.

  1. Omega–3 fatty acids prevent cardiovascular disease (CVD) events in patients with myocardial infarction or heart failure. Benefits in patients without overt CVD have not been demonstrated, though most studies d...

    Authors: Mori J. Krantz, Edward P. Havranek, Rocio I. Pereira, Brenda Beaty, Philip S. Mehler and Carlin S. Long
    Citation: Journal of Negative Results in BioMedicine 2015 14:21
    Content type: Brief report Published on:

  2. Azithromycin prophylaxis has been shown to reduce COPD exacerbations but there is poor evidence for other antibiotics. We compared exacerbation rates in COPD patients with a history of frequent exacerbations (...

    Authors: Eskandarain Shafuddin, Graham D. Mills, Mark D. Holmes, Phillippa J. Poole, Peter R. Mullins and Peter N. Black
    Citation: Journal of Negative Results in BioMedicine 2015 14:15
    Content type: Research Published on:

  3. It is unknown whether gait biomechanics in hip osteoarthritis patients with mild to moderate symptoms change following exercise therapy interventions. The aim of the present study was to compare stance phase g...

    Authors: Ingrid Eitzen, Linda Fernandes, Lars Nordsletten and May Arna Risberg
    Citation: Journal of Negative Results in BioMedicine 2015 14:5
    Content type: Research Published on:

  4. Corticoids have potent anti-inflammatory effects, which may help in relieving pain and dysfunction associated with lumbar canal stenosis. We assessed the effectiveness of a decreasing-dose regimen of oral cort...

    Authors: Luiz Claudio L Rodrigues and Jamil Natour
    Citation: Journal of Negative Results in BioMedicine 2014 13:13
    Content type: Research Published on:

  5. Current maintenance therapies for asthma require twice-daily dosing. Vilanterol (VI) is a novel long-acting beta2 agonist, under development in combination with fluticasone furoate, a new inhaled corticosteroid (...

    Authors: Jan Lötvall, Eric D Bateman, William W Busse, Paul M O’Byrne, Ashley Woodcock, William T Toler, Loretta Jacques, Caroline Goldfrad and Eugene R Bleecker
    Citation: Journal of Negative Results in BioMedicine 2014 13:9
    Content type: Research Published on:

  6. Design and execution of immunotherapy trials for seasonal allergies may be complicated by numerous factors including variable allergy testing methods, pollen levels, and timing and intensity of other seasonal ...

    Authors: Kevin Murphy, Sandra Gawchik, David Bernstein, Jens Andersen and Martin Rud Pedersen
    Citation: Journal of Negative Results in BioMedicine 2013 12:10
    Content type: Research Published on:

  7. The underlying pathology and natural course of Modic changes (MC) in the vertebral body marrow and high intensity zones (HIZs) in the annulus fibrosus is not completely clarified. These findings on magnetic re...

    Authors: Philip Wilkens, Kjersti Storheim, Inger Scheel, Linda Berg and Ansgar Espeland
    Citation: Journal of Negative Results in BioMedicine 2012 11:13
    Content type: Research Published on:

  9. Methylphenidate blocks the re-uptake of dopamine by binding to the dopamine transporter in the presynaptic cell membrane and increases extracellular dopamine levels. Similarities in neuropsychologic effects be...

    Authors: Richard D Hurt, Jon O Ebbert, Ivana T Croghan, Darrell R Schroeder, Amit Sood and J Taylor Hays
    Citation: Journal of Negative Results in BioMedicine 2011 10:1
    Content type: Research Published on:

  10. To determine the impact of pre-operative and intra-operative ilioinguinal and iliohypogastric nerve block on post-operative analgesic utilization and length of stay (LOS).

    Authors: Salim A Wehbe, Labib M Ghulmiyyah, El-Khawand H Dominique, Sarah L Hosford, Carole M Ehleben, Steven L Saltzman and Eric Scott Sills
    Citation: Journal of Negative Results in BioMedicine 2008 7:11
    Content type: Research Published on:

  11. Soy isoflavones show structural and functional similarities to estradiol. Available data indicate that estradiol and estradiol-like components may interact with gut "satiety hormones" such as peptide YY (PYY) ...

    Authors: Martin O Weickert, Manja Reimann, Bärbel Otto, Wendy L Hall, Katherina Vafeiadou, Jesper Hallund, Marika Ferrari, Duncan Talbot, Francesco Branca, Susanne Bügel, Christine M Williams, Hans-Joachim Zunft and Corinna Koebnick
    Citation: Journal of Negative Results in BioMedicine 2006 5:11
    Content type: Research Published on: