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Chromosomal Imbalances and Cancer

Edited by Emanuela V Volpi

Chromosomal imbalances have been known as common features of cancer genomes for a long time. However, we have started to comprehend their causative link to tumorigenesis only recently. Chromosomal instability – as a process leading to abnormal chromosome content and heterogeneity – has been widely researched and increasingly referred to as driving force behind malignant transformation and defining factor for cancer evolution. The aim of Molecular Cytogenetic's thematic series is to bring together the latest research findings and conceptual developments in the field of chromosomal imbalances and cancer.

This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process. The Guest Editors declare no competing interests.

  1. Content type: Research

    Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20–30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the P...

    Authors: Thiago Vidotto, Daniel Guimarães Tiezzi and Jeremy A. Squire

    Citation: Molecular Cytogenetics 2018 11:1

    Published on:

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