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Chromosomal Imbalances and Cancer

Edited by Emanuela V Volpi

Chromosomal imbalances have been known as common features of cancer genomes for a long time. However, we have started to comprehend their causative link to tumorigenesis only recently. Chromosomal instability – as a process leading to abnormal chromosome content and heterogeneity – has been widely researched and increasingly referred to as driving force behind malignant transformation and defining factor for cancer evolution. The aim of Molecular Cytogenetic's thematic series is to bring together the latest research findings and conceptual developments in the field of chromosomal imbalances and cancer.

This collection of articles has not been sponsored and articles have undergone the journal's standard peer-review process. The Guest Editors declare no competing interests.

  1. Tumorigenesis is a multi-step process which is accompanied by substantial changes in genome organization. The development of these changes is not only a random process, but rather comprise specific DNA regions...

    Authors: Christoph Standfuß, Jonas Parczyk, Jerome Ruhnau and Andreas Klein
    Citation: Molecular Cytogenetics 2019 12:25
  2. Many cancers possess an incorrect number of chromosomes, a state described as aneuploidy. Aneuploidy is often caused by Chromosomal Instability (CIN), a process of continuous chromosome mis-segregation. CIN is...

    Authors: Andréa E. Tijhuis, Sarah C. Johnson and Sarah E. McClelland
    Citation: Molecular Cytogenetics 2019 12:17
  3. In the past 15 years, impressive progress has been made to understand the molecular mechanism behind aneuploidy, largely due to the effort of using various -omics approaches to study model systems (e.g. yeast ...

    Authors: Christine J. Ye, Sarah Regan, Guo Liu, Sarah Alemara and Henry H. Heng
    Citation: Molecular Cytogenetics 2018 11:31
  4. Inactivation of the PTEN tumor suppressor gene by deletion occurs in 20–30% of prostate cancer tumors and loss strongly correlates with a worse outcome. PTEN loss of function not only leads to activation of the P...

    Authors: Thiago Vidotto, Daniel Guimarães Tiezzi and Jeremy A. Squire
    Citation: Molecular Cytogenetics 2018 11:1