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Chronic Headaches and Medication Overuse

Edited by:
Gianluca Coppola, MD, PhD, Sapienza University of Rome, Italy

Submission Status: Closed

This collection is no longer accepting submissions.

The Journal of Headache and Pain invites participating authors to submit to our Collection on Chronic Headaches and Medication Overuse. This thematic series intends to approach chronic headache and symptom overuse from a broad and multidisciplinary perspective centred on these and other unanswered concerns. 

  1. Mindfulness practice has gained interest in the management of Chronic Migraine associated with Medication Overuse Headache (CM-MOH). Mindfulness is characterized by present-moment self-awareness and relies on ...

    Authors: Davide Fedeli, Giuseppe Ciullo, Greta Demichelis, Jean Paul Medina Carrion, Maria Grazia Bruzzone, Emilio Ciusani, Alessandra Erbetta, Stefania Ferraro, Marina Grisoli, Erika Guastafierro, Domenico D’Amico, Alberto Raggi, Anna Nigri and Licia Grazzi
    Citation: The Journal of Headache and Pain 2024 25:97
  2. Medication-overuse headache (MOH), which potentially involves 1–2% of the population, is defined as a headache, on ≥ 15 days a month affected, along with overuse of one or other acute attack medications. MOH p...

    Authors: Helin Gosalia, David Moreno-Ajona and Peter J. Goadsby
    Citation: The Journal of Headache and Pain 2024 25:89
  3. Chronic headache disorders are disabling. The CHESS trial studied the effects of a short non-pharmacological intervention of education with self-management support for people affected by migraine and/or tensio...

    Authors: Siew Wan Hee, Shilpa Patel, Harbinder Sandhu, Manjit S. Matharu and Martin Underwood
    Citation: The Journal of Headache and Pain 2024 25:77
  4. Chronic migraine (CM) is a debilitating neurofunctional disorder primarily affecting females, characterized by central sensitization. Central sensitization refers to the enhanced response to sensory stimulatio...

    Authors: Lei Wang, Xiaoming Liu, Chenlu Zhu, Shouyi Wu, Zhilei Li, Lipeng Jing, Zhenchang Zhang, Yuhong Jing and Yonggang Wang
    Citation: The Journal of Headache and Pain 2024 25:74
  5. Chronic migraine (CM) negatively impacts the quality of life of 2 to 4% of pediatric patients. In adults, CM is frequently linked to medication overuse headache (MOH), but there is a much lower prevalence of M...

    Authors: Ilaria Frattale, Michela Ada Noris Ferilli, Fabiana Ursitti, Giorgia Sforza, Gabriele Monte, Martina Proietti Checchi, Samuela Tarantino, Luigi Mazzone, Massimiliano Valeriani and Laura Papetti
    Citation: The Journal of Headache and Pain 2024 25:61
  6. Phosphodiesterase 3 (PDE-3) inhibition have been implicated in the neurobiologic underpinnings of migraine. Considering the clinical similarities between migraine and persistent post-traumatic headache (PPTH),...

    Authors: Haidar M. Al-Khazali, Rune H. Christensen, Basit Ali Chaudhry, Anna G. Melchior, Messoud Ashina, Rami Burstein and Håkan Ashina
    Citation: The Journal of Headache and Pain 2024 25:56
  7. Chronic migraine is a highly debilitating condition that is often difficult to manage, particularly in the presence of medication overuse headache. Drugs targeting the calcitonin gene-related peptide (CGRP), o...

    Authors: Renato Oliveira, Raquel Gil-Gouveia and Francesca Puledda
    Citation: The Journal of Headache and Pain 2024 25:51
  8. The efficiency of The International Classification of Headache Disorders (ICHD-3) in reflecting patients’ disability has recently been questioned. This prompts consideration that clinical features beyond pain ...

    Authors: Tatiana Castro Zamparella, Mariela Carpinella, Mario Peres, Florencia Patricia Cuello, Pilar Maza, Melanie Van Gansen, Marcelo Filipchuk, Verónica Balaszczuk, Carolina Maldonado, Pablo Scarnato, Diego Conci Magris and Marco Lisicki
    Citation: The Journal of Headache and Pain 2024 25:37
  9. Medication overuse headache (MOH) was recently shown to be associated with leaky gut in rodents. We aimed to investigate whether chronic migraine (CM) patients with MOH have elevated lipopolysaccharide levels ...

    Authors: Doga Vuralli, Merve Ceren Akgor, Hale Gok Dagidir, Ozlem Gulbahar, Meltem Yalinay and Hayrunnisa Bolay
    Citation: The Journal of Headache and Pain 2024 25:23
  10. Several risk factors are associated with the chronic evolution of migraine. Clinical and preclinical studies have provided data about the role of hypertension (HT) as one of the potential modifiable risk facto...

    Authors: Federico Mazzacane, Gloria Vaghi, Matteo Cotta Ramusino, Giulia Perini and Alfredo Costa
    Citation: The Journal of Headache and Pain 2024 25:13
  11. The present study aimed to compare sex differences in the clinical manifestations related to dependence behaviors in medication-overuse headache (MOH).

    Authors: Yen-Feng Wang, Yi-Shiang Tzeng, Chia-Chun Yu, Yu-Hsiang Ling, Shih-Pin Chen, Kuan-Lin Lai, Wei-Ta Chen and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2023 24:145
  12. To determine specific resting-state network patterns underlying alterations in chronic migraine, we employed oscillatory connectivity and machine learning techniques to distinguish patients with chronic migrai...

    Authors: Fu-Jung Hsiao, Wei-Ta Chen, Yu-Te Wu, Li-Ling Hope Pan, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Gianluca Coppola and Shuu-Jiun Wang
    Citation: The Journal of Headache and Pain 2023 24:139
  13. Migraine, a complex brain disorder, is regarded as a possible clinical manifestation of brain energy dysfunction. The trigeminovascular system is considered the basis for the pathogenesis of migraine, hence we...

    Authors: Wei Xie, Ruibing Li, Wenjing Tang, Zhenjie Ma, Shuai Miao, Chenhao Li, Chunxiao Yang, Bozhi Li, Tao Wang, Zihua Gong, Yue Zhou and Shengyuan Yu
    Citation: The Journal of Headache and Pain 2023 24:122
  14. Central sensitisation is an important mechanism in migraine chronification. It is presumed to occur in second and third order neurons sequentially, resulting in an analogous spatial distribution of cutaneous a...

    Authors: Judith A. Pijpers, Dennis A. Kies, Erik W. van Zwet, Irene de Boer and Gisela M. Terwindt
    Citation: The Journal of Headache and Pain 2023 24:118
  15. The evidence supporting the efficacy of dietary preventive therapy in migraine is rising, particularly regarding the ketogenic diet. However, less evidence exists for the Low-Glycemic Index Diet and the 2:1 KD...

    Authors: Yan Tereshko, Simone Dal Bello, Cherubino Di Lorenzo, Sara Pez, Alice Pittino, Roberto Sartor, Francesca Filippi, Christian Lettieri, Enrico Belgrado, Riccardo Garbo, Giovanni Merlino, Gian Luigi Gigli and Mariarosaria Valente
    Citation: The Journal of Headache and Pain 2023 24:95
  16. Social cognition refers to all mental operations to decipher information needed in social interactions. Here we aimed to outline the socio-cognitive profile of Chronic Migraine with Medication Overuse (CM + MO...

    Authors: Sara Bottiroli, Alessia Rosi, Grazia Sances, Marta Allena, Roberto De Icco, Serena Lecce, Tomaso Vecchi, Cristina Tassorelli and Elena Cavallini
    Citation: The Journal of Headache and Pain 2023 24:47

Meet the Guest Editors

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Gianluca Coppola; Sapienza University of Rome, Italy

Gianluca Coppola, MD, PhD, is a clinical neurologist at Sapienza University of Rome Polo Pontino ICOT. He is trustee for the International Headache Society and active member of the Italian Societies for the Study of Headache, of Clinical Neurophysiology, of Neurology, and of Psychophysiology and Cognitive Neurosciences. His research interests include the use of electrophysiology and neuroimaging techniques to understand primary headaches pathophysiology, and to study visual, somatosensory, and motor systems synaptic plasticity mechanisms.


About the Collection

The classification criteria for chronic headaches and the pathophysiological mechanisms behind the transition from episodic to chronic remain controversial despite the significant clinical and pathophysiological advances made in recent years. Actually, there are still a lot of open questions: How can the many types of chronic headaches be distinguished by a proper diagnosis? What personality features best describe a chronic patient, and what conditions make them more likely to overuse symptomatic medications? Which detox program is most effective? Is a headache brought on by acute medication overuse the transformation's cause or effect? Is medication overuse exclusive to migraine and tension-type headaches, or can it also occur with other primary headaches? Which patients run the risk of losing their response to standard preventatives? Could comorbid conditions be a factor in this scenario? What are the most effective pharmacological and non-pharmacological methods for treating chronic headaches and symptomatic overuse? What are the morphofunctional and genetic underpinnings of transformation and symptomatic overuse?

This thematic series, which intends to approach chronic headache and symptom overuse from a broad and multidisciplinary perspective, will be centred on these and other unanswered concerns. The ultimate goal is to assist in unravelling the intricate mechanisms behind this range of disorders in order to enhance diagnosis and therapy.

Submission Guidelines

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This Collection invites participating authors to submit Research Articles. Before submitting your manuscript, please ensure you have read our submission guidelines. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select Chronic Headaches and Medication Overuse from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer-review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.