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Chemical Proteomics

Edited by Ho Jeong Kwon and Peter Karuso

Proteomics is a relatively new field of research that evolved from electrophoresis and the desire to investigate proteins on a genome-wide basis.  More recently the development of Chemical Proteomics marks the crossing of proteomics into the discipline of chemistry and is quickly becoming an integrated research engine that bridges the hurdle of identifying protein targets of biologically active small molecules with unknown modes of action. Chemical proteomics provides a high-throughput platform for exploring drug-target-phenotype relationships required for functional proteomics and rapid drug discovery. These efforts are illuminating a new paradigm in drug discovery where a priori knowledge of a new chemical entity’s mode of action is not required for the rapid isolation of novel targets.

Proteome Science highlights the emergence of this new and dynamic field with a special issue focused on chemical proteomics methods and their applications.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

  1. Content type: Research

    Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors...

    Authors: Margaret L. Wong, Jason Murphy, Edmund Harrington, Carrie M. Gower, Rishi K. Jain, Markus Schirle and Jason R. Thomas

    Citation: Proteome Science 2017 15:17

    Published on:

  2. Content type: Review

    Determining small molecule—target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class m...

    Authors: Kyungtae Kang, Jongmin Park and Eunha Kim

    Citation: Proteome Science 2017 15:15

    Published on:

  3. Content type: Review

    Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that are crucial for biomedical research and drug discovery. Various techniques have been used to study specific protei...

    Authors: Dhiraj P. Murale, Seong Cheol Hong, Md. Mamunul Haque and Jun-Seok Lee

    Citation: Proteome Science 2017 15:14

    Published on:

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