Skip to main content

Chemical Proteomics

Edited by Ho Jeong Kwon and Peter Karuso

Proteomics is a relatively new field of research that evolved from electrophoresis and the desire to investigate proteins on a genome-wide basis.  More recently the development of Chemical Proteomics marks the crossing of proteomics into the discipline of chemistry and is quickly becoming an integrated research engine that bridges the hurdle of identifying protein targets of biologically active small molecules with unknown modes of action. Chemical proteomics provides a high-throughput platform for exploring drug-target-phenotype relationships required for functional proteomics and rapid drug discovery. These efforts are illuminating a new paradigm in drug discovery where a priori knowledge of a new chemical entity’s mode of action is not required for the rapid isolation of novel targets.

Proteome Science highlights the emergence of this new and dynamic field with a special issue focused on chemical proteomics methods and their applications.

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process. The Guest Editors declare no competing interests.

  1. Chronic hepatitis B is a significant public health problem and complex pathologic process, and unraveling the underlying mechanisms and pathophysiology is of great significance. Data independent acquisition ma...

    Authors: Bo Wang, Qian Zhang, Lili Wu, Cunliang Deng, Meiyan Luo, Yu Xie, Gang Wu, Wen Chen, Yunjian Sheng, Peng Zhu and Gang Qin
    Citation: Proteome Science 2023 21:9
    Content type: Research Published on:

  2. This study aims to explore the effect of an extract of Atractylodes lancea (A. lancea) on antibiotics-induced intestinal tract disorder and the probable therapeutic mechanisms employed by this extract to ameliora...

    Authors: BaiNian Zhang, Lan Bu, Hui Tian, ZhangQiang You, MingHai Zhao, Jie Tian, YuanYuan Zhang, Qian Wang, ChengJia Tan, Yu Cao, DaRen Feng and ZhenPeng Xi
    Citation: Proteome Science 2023 21:5
    Content type: Research Published on:

  3. Macrophages have a vital role in phagocytosis and antiviral effect against invading influenza viruses. Previously, we found that methionine enkephalin (MENK) inhibited influenza virus infection by upregulating...

    Authors: Wenrui Fu, Zifeng Xie, Mei Bai, Zhen Zhang, Yuanlong Zhao and Jing Tian
    Citation: Proteome Science 2023 21:4
    Content type: Research Published on:

  4. Exosomes in the body fluid are effective cell-derived membranous structures transferring various molecules to mediate intercellular communication. The expression of protein in the urinary exosomes from the col...

    Authors: Ling Ma, Haijiao Yu, Yubing Zhu, Kaiyu Xu, Aimin Zhao, Lei Ding, Hong Gao and Man Zhang
    Citation: Proteome Science 2023 21:3
    Content type: Research Published on:

  5. Horticulture productivity has been increasingly restricted by heat stress from growing global warming, making it far below the optimum production capacity. As a popular ornamental cultivar of tree peony, Paeonia ...

    Authors: Jin Ma, Qun Wang, Ling-Ling Wei, Yu Zhao, Guo-Zhe Zhang, Jie Wang and Cui-Hua Gu
    Citation: Proteome Science 2022 20:18
    Content type: Research Published on:

  6. Hypoxia is a risk factor for non-alcoholic fatty liver diseases, leading to permanent imbalance of liver lipid homeostasis and steatohepatitis. However, a detailed understanding of the metabolic genes and path...

    Authors: Jin Xu, Wen-jie Chen, Zhan Wang, Ming-yuan Xin, Shen-han Gao, Wen-jing Liu, Kai-kun Wang, Jing-wei Ma, Xin-zong Yan and Yan-ming Ren
    Citation: Proteome Science 2022 20:16
    Content type: Research Published on:

  7. Multi-omics technology provides a good tool to analyze the protein toxin composition and search for the potential pathogenic factors of Solenopsis invicta, under the great harm of the accelerated invasion in sout...

    Authors: Liuyang Cai, Fengling Yang, Yongfang Wang, Jishun Yang, Yina Zhu, Xueqi Ma, Juan Höfer, Yichao Wang, Yajun Ma and Liang Xiao
    Citation: Proteome Science 2022 20:15
    Content type: Research Published on:

  8. Understanding the molecular and cellular mechanisms involved in the pathogenesis of ocular injured induced by mustard gas can help better identify complications and discover appropriate therapies. This study a...

    Authors: Shahram Parvin, Alireza Shahriary, Hossein Aghamollaei, B. Fatemeh Nobakht M. Gh, Hasan Bagheri, Mostafa Ghanei, Seyed-Hashem Daryabari, Khosrow Jadidi and Masoud Arabfard
    Citation: Proteome Science 2022 20:13
    Content type: Research Published on:

  10. Protein lysine malonylation, a novel post-translational modification (PTM), has been recently linked with energy metabolism in bacteria. Staphylococcus aureus is the third most important foodborne pathogen worldw...

    Authors: Yanan Shi, Jingjing Zhu, Yan Xu, Xiaozhao Tang, Zushun Yang and Aixiang Huang
    Citation: Proteome Science 2021 19:1
    Content type: Research Published on:

  11. Protein kinase C ζ (PKCζ), an isoform of the atypical protein kinase C, is a pivotal regulator in cancer. However, the molecular and cellular mechanisms whereby PKCζ regulates tumorigenesis and metastasis are ...

    Authors: Chunyu Hou, Yuan Li, Huiqin Liu, Mengjiao Dang, Guoxuan Qin, Ning Zhang and Ruibing Chen
    Citation: Proteome Science 2018 16:5
    Content type: Research Published on:

  13. Identifying selective kinase inhibitors remains a major challenge. The design of bivalent inhibitors provides a rational strategy for accessing potent and selective inhibitors. While bivalent kinase inhibitors...

    Authors: Margaret L. Wong, Jason Murphy, Edmund Harrington, Carrie M. Gower, Rishi K. Jain, Markus Schirle and Jason R. Thomas
    Citation: Proteome Science 2017 15:17
    Content type: Research Published on:

  15. Determining small molecule—target protein interaction is essential for the chemical proteomics. One of the most important keys to explore biological system in chemical proteomics field is finding first-class m...

    Authors: Kyungtae Kang, Jongmin Park and Eunha Kim
    Citation: Proteome Science 2017 15:15
    Content type: Review Published on:

  16. Protein-protein interactions (PPIs) trigger a wide range of biological signaling pathways that are crucial for biomedical research and drug discovery. Various techniques have been used to study specific protei...

    Authors: Dhiraj P. Murale, Seong Cheol Hong, Md. Mamunul Haque and Jun-Seok Lee
    Citation: Proteome Science 2017 15:14
    Content type: Review Published on:

  17. In recent years, phenotypic-based screens have become increasingly popular in drug discovery. A major challenge of this approach is that it does not provide information about the mechanism of action of the hit...

    Authors: André Mateus, Tomi A. Määttä and Mikhail M. Savitski
    Citation: Proteome Science 2017 15:13
    Content type: Review Published on: