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BioMedical Engineering and the Heart

Coronary Blood Flow, Myocardial Perfusion, Myocardial Ischemia and Infarcts Detection, Customized Stents and Bypass Surgery

Dhanjoo Ghista and Kelvin Wong

Stents and bypass surgeries have become standard treatment for ischemic heart disease, a top cause of death worldwide. This BioMedical Engineering OnLine thematic series addresses the urgent scientific and clinical need to further investigate the dynamics of blood flow, occluded arteries, and structural variations contributing to myocardial ischemic regions. Doing so will help to unveil the mechanism underlying this disease and inspire technological advances that will improve diagnosis and treatment of coronary heart diseases.

The series focuses on computational analysis of the engineering, medical, and surgical aspects of cardiology, and welcomes submissions from these disciplines.

  1. Patients with end-stage heart failure must receive treatment to recover cardiac function, and the current primary therapy, heart transplantation, is plagued by the limited supply of donor hearts. Bioengineered...

    Authors: Cailing Tong, Cheng Li, Baiyi Xie, Minghui Li, Xianguo Li, Zhongquan Qi and Junjie Xia
    Citation: BioMedical Engineering OnLine 2019 18:71
    Content type: Research Published on:

  2. The direction of the current research was to investigate whether electrocardiogram (ECG) signals have been impacted by using compression garments during exercise and recovery phase. Each subject is non-athlete...

    Authors: Lan Thi Nhu Nguyen, David Eager and Hung Nguyen
    Citation: BioMedical Engineering OnLine 2019 18:27
    Content type: Research Published on:

  3. Serial electrocardiography aims to contribute to electrocardiogram (ECG) diagnosis by comparing the ECG under consideration with a previously made ECG in the same individual. Here, we present a novel algorithm...

    Authors: Agnese Sbrollini, Marjolein C. De Jongh, C. Cato Ter Haar, Roderick W. Treskes, Sumche Man, Laura Burattini and Cees A. Swenne
    Citation: BioMedical Engineering OnLine 2019 18:15
    Content type: Research Published on:

  5. Acute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways r...

    Authors: Zhihua Liu, Chenguang Ma, Junhua Gu and Ming Yu
    Citation: BioMedical Engineering OnLine 2019 18:9
    Content type: Research Published on:

  7. Rotary blood pumps (RBPs) are the newest generation of ventricular assist devices. Although their continuous flow characteristics have been accepted widely, more and more research has focused on the pulsatile ...

    Authors: Feng Huang, Zhe Gou, Yang Fu and Xiaodong Ruan
    Citation: BioMedical Engineering OnLine 2018 17:142
    Content type: Research Published on:

  8. This study aims to use a wall shear stress (WSS) quantitative analysis software to analyze and evaluate the carotid sinus WSS spatial distribution and characteristics in intima-media thickness (IMT) normal and...

    Authors: Bo Zhang, Yuqin Ma and Fang Ding
    Citation: BioMedical Engineering OnLine 2018 17:141
    Content type: Research Published on:

  9. Patients with uremia have high cardiovascular disease morbidity and mortality despite having normal left ventricular ejection fraction (LVEF). Longitudinal strain (LS) can be associated with subtle changes in ...

    Authors: Yuqin Ma, Bo Zhang, Yuzhen Zhang, Yun Dong and Ruiqing Zhang
    Citation: BioMedical Engineering OnLine 2018 17:112
    Content type: Research Published on:

  10. Electroencephalogram-based brain–computer interfaces (BCIs) represent novel human machine interactive technology that allows people to communicate and interact with the external world without relying on their ...

    Authors: Jingsheng Tang, Yadong Liu, Dewen Hu and ZongTan Zhou
    Citation: BioMedical Engineering OnLine 2018 17:111
    Content type: Research Published on:

  11. For practical straight-line scanning in photoacoustic imaging (PAI), serious artifacts caused by missing data will occur. Traditional total variation (TV)-based algorithms fail to obtain satisfactory results, ...

    Authors: Jin Wang and Yuanyuan Wang
    Citation: BioMedical Engineering OnLine 2018 17:105
    Content type: Research Published on:

  12. Thyroid imaging reporting and data system (TIRADS) is the assessment of a risk stratification of thyroid nodules, usually using a score. However, there is no consensus as to the version of TIRADS for reporting...

    Authors: Yan Zhuang, Cheng Li, Zhan Hua, Ke Chen and Jiang Li Lin
    Citation: BioMedical Engineering OnLine 2018 17:82
    Content type: Research Published on:

  13. Fractional flow reverse (FFR) is the gold standard assessment of the hemodynamic significance of coronary stenoses. However, it requires the catheterization of the coronary artery to determine the pressure wav...

    Authors: R. Agujetas, M. R. González-Fernández, J. M. Nogales-Asensio and J. M. Montanero
    Citation: BioMedical Engineering OnLine 2018 17:67
    Content type: Research Published on:

  16. Hemodynamic information including peak systolic pressure (PSP) and peak systolic velocity (PSV) carry an important role in evaluation and diagnosis of congenital heart disease (CHD). Since MDCTA cannot evaluat...

    Authors: Yulei Zhu, Rui Chen, Yu-Hsiang Juan, He Li, Jingjing Wang, Zhuliang Yu and Hui Liu
    Citation: BioMedical Engineering OnLine 2018 17:53
    Content type: Research Published on:

  18. This study aimed to investigate the influence of injection rates of calibrating standard solution on monitoring pulse indicator continuous cardiac output (PICCO, made in Germany), and thereby to provide signi...

    Authors: Chen Shu-Lan, Lan Fang-Chen, Du Zhen-Shuang, Xu Ya-Ping, Zhao Hui-Ming, Zeng Cui-Ping and Miao Yu
    Citation: BioMedical Engineering OnLine 2018 17:34
    Content type: Research Published on:

  19. Cerebrovascular events are frequently associated with hemodynamic disturbance caused by internal carotid artery (ICA) stenosis. It is challenging to determine the ischemia-related carotid stenosis during the i...

    Authors: Dong Zhang, Pengcheng Xu, Hongyu Qiao, Xin Liu, Liangping Luo, Wenhua Huang, Heye Zhang and Changzheng Shi
    Citation: BioMedical Engineering OnLine 2018 17:31
    Content type: Research Published on:

  20. Many studies have demonstrated that the geometry of the carotid bifurcation enables prediction of blood flow variation associated with atherosclerotic plaque formation. The phase angle between the arterial wal...

    Authors: Lili Niu, Xiliang Zhu, Min Pan, Abbott Derek, Lisheng Xu, Long Meng and Hairong Zheng
    Citation: BioMedical Engineering OnLine 2018 17:30
    Content type: Research Published on:

  21. This paper presents the use of the texture matching method to measure the rabbit carotid artery elasticity value of the experimental group and control group respectively. It compares the experimental rabbits, ...

    Authors: Bo Zhang, Junyi Gu, Ming Qian, Lili Niu and Dhanjoo Ghista
    Citation: BioMedical Engineering OnLine 2018 17:5
    Content type: Research Published on:

  22. R-wave synchronised atrial pacing is an effective temporary pacing therapy in infants with postoperative junctional ectopic tachycardia. In the technique currently used, adverse short or long intervals between...

    Authors: Andreas Entenmann, Miriam Michel, Bruno Ismer and Roman Gebauer
    Citation: BioMedical Engineering OnLine 2017 16:139
    Content type: Research Published on:

  23. This paper presents quantitative analysis of blood flow shear stress by measuring the carotid arterial wall shear stress (WSS) and the intima-media thickness (IMT) of experimental rabbits fed with high-fat fee...

    Authors: Bo Zhang, Junyi Gu, Ming Qian, Lili Niu, Hui Zhou and Dhanjoo Ghista
    Citation: BioMedical Engineering OnLine 2017 16:137
    Content type: Research Published on:

  24. Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeu...

    Authors: Weiting Chen, Huijuan Zhao, Tongxin Li, Panpan Yan, Kuanxin Zhao, Caixia Qi and Feng Gao
    Citation: BioMedical Engineering OnLine 2017 16:100
    Content type: Research Published on:

  25. The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on c...

    Authors: Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu and Heye Zhang
    Citation: BioMedical Engineering OnLine 2017 16:43
    Content type: Research Published on:

  26. Cardiac dysfunction constitutes common cardiovascular health issues in the society, and has been an investigation topic of strong focus by researchers in the medical imaging community. Diagnostic modalities ba...

    Authors: Kelvin K. L. Wong, Defeng Wang, Jacky K. L. Ko, Jagannath Mazumdar, Thu-Thao Le and Dhanjoo Ghista
    Citation: BioMedical Engineering OnLine 2017 16:35
    Content type: Review Published on:

  27. Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when p...

    Authors: Francesca Maria Susin, Stefania Espa, Riccardo Toninato, Stefania Fortini and Giorgio Querzoli
    Citation: BioMedical Engineering OnLine 2017 16:29
    Content type: Research Published on:

  28. Since the electrocardiogram (ECG) signal has a low frequency and a weak amplitude, it is sensitive to miscellaneous mixed noises, which may reduce the diagnostic accuracy and hinder the physician’s correct dec...

    Authors: Oussama El B’charri, Rachid Latif, Khalifa Elmansouri, Abdenbi Abenaou and Wissam Jenkal
    Citation: BioMedical Engineering OnLine 2017 16:26
    Content type: Research Published on:

  30. Although stents have great success of treating cardiovascular disease, it actually undermined by the in-stent restenosis and their long-term fatigue failure. The geometry of stent affects its service performan...

    Authors: Hongxia Li, Tao Liu, Minjie Wang, Danyang Zhao, Aike Qiao, Xue Wang, Junfeng Gu, Zheng Li and Bao Zhu
    Citation: BioMedical Engineering OnLine 2017 16:13
    Content type: Research Published on:

  31. The goal of this paper is to present a computational fluid dynamic (CFD) model with moving boundaries to study the intraventricular flows in a patient-specific framework. Starting from the segmentation of real...

    Authors: A. M. Bavo, A. M. Pouch, J. Degroote, J. Vierendeels, J. H. Gorman, R. C. Gorman and P. Segers
    Citation: BioMedical Engineering OnLine 2016 15:107
    Content type: Research Published on:

  32. Cardiovascular disease (CVD), the leading cause of death today, incorporates a wide range of cardiovascular system malfunctions that affect heart functionality. It is believed that the hemodynamic loads exerte...

    Authors: Siamak N. Doost, Dhanjoo Ghista, Boyang Su, Liang Zhong and Yosry S. Morsi
    Citation: BioMedical Engineering OnLine 2016 15:101
    Content type: Review Published on:

  33. Misalignment in cardiac magnetic resonance (CMR) images can adversely affect three-dimensional left ventricle modelling and downstream quantitative analysis. Currently, there are two types of approaches for de...

    Authors: Min Wan, Wei Huang, Jun-Mei Zhang, Xiaodan Zhao, John Carson Allen, Ru San Tan, Xiaofeng Wan and Liang Zhong
    Citation: BioMedical Engineering OnLine 2016 15:93
    Content type: Research Published on:

  34. Coronary hemodynamics and physiology specific for bifurcation lesions was not well understood. To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesion...

    Authors: Claudio Chiastra, Francesco Iannaccone, Maik J. Grundeken, Frank J. H. Gijsen, Patrick Segers, Matthieu De Beule, Patrick W. Serruys, Joanna J. Wykrzykowska, Antonius F. W. van der Steen and Jolanda J. Wentzel
    Citation: BioMedical Engineering OnLine 2016 15:91
    Content type: Research Published on:

  35. Osseointegration refers to the direct connection between living bone and the surface of a load-bearing artificial implant. Porous implants with well-controlled porosity and pore size can enhance osseointegrati...

    Authors: Wei Peng, Liangwei Xu, Jia You, Lihua Fang and Qing Zhang
    Citation: BioMedical Engineering OnLine 2016 15:85
    Content type: Research Published on:

  36. Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients.

    Authors: Xu Zhang, Meimei Zhang, Shengkun Zheng, Liqi Wang and Jilun Ye
    Citation: BioMedical Engineering OnLine 2016 15:84
    Content type: Research Published on:

  38. Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascu...

    Authors: Annette M. Kok, Lambert Speelman, Renu Virmani, Antonius F. W. van der Steen, Frank J. H. Gijsen and Jolanda J. Wentzel
    Citation: BioMedical Engineering OnLine 2016 15:48
    Content type: Research Published on:

  40. Electrogram-guided ablation procedures have been proposed as an alternative strategy consisting of either mapping and ablating focal sources or targeting complex fractionated electrograms in atrial fibrillatio...

    Authors: Andres Orozco-Duque, John Bustamante and German Castellanos-Dominguez
    Citation: BioMedical Engineering OnLine 2016 15:44
    Content type: Research Published on:

  42. Using of active cardiac medical devices increases steadily. In Europe, there were 183 implants of ICD and 944 implants of PM, 119 of biventricular ICD and 41 of biventricular PM, all per million inhabitants in...

    Authors: Martin Augustynek, David Korpas, Marek Penhaker, Jakub Cvek and Andrea Binarova
    Citation: BioMedical Engineering OnLine 2016 15:29
    Content type: Research Published on:

  43. Areas with high frequency activity within the atrium are thought to be ‘drivers’ of the rhythm in patients with atrial fibrillation (AF) and ablation of these areas seems to be an effective therapy in eliminat...

    Authors: João L. Salinet, Nicholas Masca, Peter J. Stafford, G. André Ng and Fernando S. Schlindwein
    Citation: BioMedical Engineering OnLine 2016 15:28
    Content type: Research Published on:

  44. Double injection of blood into cisterna magna using a rabbit model results in cerebral vasospasm. An unacceptably high mortality rate tends to limit the application of model. Ultrasound guided puncture can pro...

    Authors: Yongchao Chen, Youzhi Zhu, Yu Zhang, Zixuan Zhang, Juan Lian, Fucheng Luo, Xuefei Deng and Kelvin KL Wong
    Citation: BioMedical Engineering OnLine 2016 15:19
    Content type: Research Published on:

  45. High blood pressure (BP) is among significant risk factor for stroke and other vascular occurrences, it experiences nonstop fluctuations over time as a result of a complex interface among cardiovascular contro...

    Authors: Yujie Chen, Huahua Xiong, Dan Wu, Sandeep Pirbhulal, Xiaohong Tian, Ruiqin Zhang, Minhua Lu, Wanqing Wu and Wenhua Huang
    Citation: BioMedical Engineering OnLine 2015 14:71
    Content type: Research Published on:

  46. The dynamic expressions of monocyte chemo attractant protein-1 (MCP-1) and CC chamomile receptor 2 (CCR2) after balloon injury and their effects in intimal proliferation were discussed. In this study, the expr...

    Authors: Zhigang Huang, Yuebing Li, Lili Niu, Yang Xiao, Xiaodong Pu, Hairong Zheng and Ming Qian
    Citation: BioMedical Engineering OnLine 2015 14:55
    Content type: Research Published on:

  47. We sought to evaluate the accuracy of quantitative three-dimensional (3D) CT angiography (CTA) for the assessment of coronary luminal stenosis using digital subtraction angiography (DSA) as the standard of ref...

    Authors: Wei Guo, Xin Liu, Zhifan Gao, Sandeep Pirbhulal, Wenhua Huang, Wan-Hua Lin, Heye Zhang, Ning Tan and Yuan-Ting Zhang
    Citation: BioMedical Engineering OnLine 2015 14:50
    Content type: Research Published on: