Skip to main content


BioMedical Engineering and the Heart

Coronary Blood Flow, Myocardial Perfusion, Myocardial Ischemia and Infarcts Detection, Customized Stents and Bypass Surgery

Dhanjoo Ghista and Kelvin Wong

Stents and bypass surgeries have become standard treatment for ischemic heart disease, a top cause of death worldwide. This BioMedical Engineering OnLine thematic series addresses the urgent scientific and clinical need to further investigate the dynamics of blood flow, occluded arteries, and structural variations contributing to myocardial ischemic regions. Doing so will help to unveil the mechanism underlying this disease and inspire technological advances that will improve diagnosis and treatment of coronary heart diseases.

The series focuses on computational analysis of the engineering, medical, and surgical aspects of cardiology, and welcomes submissions from these disciplines.

  1. Research

    Reference-free determination of tissue absorption coefficient by modulation transfer function characterization in spatial frequency domain

    Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeu...

    Weiting Chen, Huijuan Zhao, Tongxin Li, Panpan Yan, Kuanxin Zhao, Caixia Qi and Feng Gao

    BioMedical Engineering OnLine 2017 16:100

    Published on: 8 August 2017

  2. Research

    A study of noninvasive fractional flow reserve derived from a simplified method based on coronary computed tomography angiography in suspected coronary artery disease

    The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on c...

    Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu and Heye Zhang

    BioMedical Engineering OnLine 2017 16:43

    Published on: 14 April 2017

  3. Review

    Computational medical imaging and hemodynamics framework for functional analysis and assessment of cardiovascular structures

    Cardiac dysfunction constitutes common cardiovascular health issues in the society, and has been an investigation topic of strong focus by researchers in the medical imaging community. Diagnostic modalities ba...

    Kelvin K. L. Wong, Defeng Wang, Jacky K. L. Ko, Jagannath Mazumdar, Thu-Thao Le and Dhanjoo Ghista

    BioMedical Engineering OnLine 2017 16:35

    Published on: 21 March 2017

  4. Research

    ECG signal performance de-noising assessment based on threshold tuning of dual-tree wavelet transform

    Since the electrocardiogram (ECG) signal has a low frequency and a weak amplitude, it is sensitive to miscellaneous mixed noises, which may reduce the diagnostic accuracy and hinder the physician’s correct dec...

    Oussama El B’charri, Rachid Latif, Khalifa Elmansouri, Abdenbi Abenaou and Wissam Jenkal

    BioMedical Engineering OnLine 2017 16:26

    Published on: 7 February 2017

  5. Research

    Design optimization of stent and its dilatation balloon using kriging surrogate model

    Although stents have great success of treating cardiovascular disease, it actually undermined by the in-stent restenosis and their long-term fatigue failure. The geometry of stent affects its service performan...

    Hongxia Li, Tao Liu, Minjie Wang, Danyang Zhao, Aike Qiao, Xue Wang, Junfeng Gu, Zheng Li and Bao Zhu

    BioMedical Engineering OnLine 2017 16:13

    Published on: 11 January 2017

  6. Research

    Patient-specific CFD simulation of intraventricular haemodynamics based on 3D ultrasound imaging

    The goal of this paper is to present a computational fluid dynamic (CFD) model with moving boundaries to study the intraventricular flows in a patient-specific framework. Starting from the segmentation of real...

    A. M. Bavo, A. M. Pouch, J. Degroote, J. Vierendeels, J. H. Gorman, R. C. Gorman and P. Segers

    BioMedical Engineering OnLine 2016 15:107

    Published on: 9 September 2016

  7. Review

    Heart blood flow simulation: a perspective review

    Cardiovascular disease (CVD), the leading cause of death today, incorporates a wide range of cardiovascular system malfunctions that affect heart functionality. It is believed that the hemodynamic loads exerte...

    Siamak N. Doost, Dhanjoo Ghista, Boyang Su, Liang Zhong and Yosry S. Morsi

    BioMedical Engineering OnLine 2016 15:101

    Published on: 25 August 2016

  8. Research

    Correcting motion in multiplanar cardiac magnetic resonance images

    Misalignment in cardiac magnetic resonance (CMR) images can adversely affect three-dimensional left ventricle modelling and downstream quantitative analysis. Currently, there are two types of approaches for de...

    Min Wan, Wei Huang, Jun-Mei Zhang, Xiaodan Zhao, John Carson Allen, Ru San Tan, Xiaofeng Wan and Liang Zhong

    BioMedical Engineering OnLine 2016 15:93

    Published on: 8 August 2016

  9. Research

    Coronary fractional flow reserve measurements of a stenosed side branch: a computational study investigating the influence of the bifurcation angle

    Coronary hemodynamics and physiology specific for bifurcation lesions was not well understood. To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesion...

    Claudio Chiastra, Francesco Iannaccone, Maik J. Grundeken, Frank J. H. Gijsen, Patrick Segers, Matthieu De Beule, Patrick W. Serruys, Joanna J. Wykrzykowska, Antonius F. W. van der Steen and Jolanda J. Wentzel

    BioMedical Engineering OnLine 2016 15:91

    Published on: 5 August 2016

  10. Research

    A new method for noninvasive venous blood oxygen detection

    Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients.

    Xu Zhang, Meimei Zhang, Shengkun Zheng, Liqi Wang and Jilun Ye

    BioMedical Engineering OnLine 2016 15:84

    Published on: 19 July 2016

  11. Research

    Peak cap stress calculations in coronary atherosclerotic plaques with an incomplete necrotic core geometry

    Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascu...

    Annette M. Kok, Lambert Speelman, Renu Virmani, Antonius F. W. van der Steen, Frank J. H. Gijsen and Jolanda J. Wentzel

    BioMedical Engineering OnLine 2016 15:48

    Published on: 4 May 2016

  12. Research

    Monitoring of CRT-D devices during radiation therapy in vitro

    Using of active cardiac medical devices increases steadily. In Europe, there were 183 implants of ICD and 944 implants of PM, 119 of biventricular ICD and 41 of biventricular PM, all per million inhabitants in...

    Martin Augustynek, David Korpas, Marek Penhaker, Jakub Cvek and Andrea Binarova

    BioMedical Engineering OnLine 2016 15:29

    Published on: 9 March 2016

  13. Research

    Three-dimensional dominant frequency mapping using autoregressive spectral analysis of atrial electrograms of patients in persistent atrial fibrillation

    Areas with high frequency activity within the atrium are thought to be ‘drivers’ of the rhythm in patients with atrial fibrillation (AF) and ablation of these areas seems to be an effective therapy in eliminat...

    João L. Salinet, Nicholas Masca, Peter J. Stafford, G. André Ng and Fernando S. Schlindwein

    BioMedical Engineering OnLine 2016 15:28

    Published on: 8 March 2016

  14. Research

    Ultrasound guided double injection of blood into cisterna magna: a rabbit model for treatment of cerebral vasospasm

    Double injection of blood into cisterna magna using a rabbit model results in cerebral vasospasm. An unacceptably high mortality rate tends to limit the application of model. Ultrasound guided puncture can pro...

    Yongchao Chen, Youzhi Zhu, Yu Zhang, Zixuan Zhang, Juan Lian, Fucheng Luo, Xuefei Deng and Kelvin KL Wong

    BioMedical Engineering OnLine 2016 15:19

    Published on: 6 February 2016

  15. Research

    Relationship of short-term blood pressure variability with carotid intima-media thickness in hypertensive patients

    High blood pressure (BP) is among significant risk factor for stroke and other vascular occurrences, it experiences nonstop fluctuations over time as a result of a complex interface among cardiovascular contro...

    Yujie Chen, Huahua Xiong, Dan Wu, Sandeep Pirbhulal, Xiaohong Tian, Ruiqin Zhang, Minhua Lu, Wanqing Wu and Wenhua Huang

    BioMedical Engineering OnLine 2015 14:71

    Published on: 24 July 2015

  16. Research

    Dynamic expressions of monocyte chemo attractant protein-1 and CC chamomile receptor 2 after balloon injury and their effects in intimal proliferation

    The dynamic expressions of monocyte chemo attractant protein-1 (MCP-1) and CC chamomile receptor 2 (CCR2) after balloon injury and their effects in intimal proliferation were discussed. In this study, the expr...

    Zhigang Huang, Yuebing Li, Lili Niu, Yang Xiao, Xiaodong Pu, Hairong Zheng and Ming Qian

    BioMedical Engineering OnLine 2015 14:55

    Published on: 11 June 2015

  17. Research

    Quantification of three-dimensional computed tomography angiography for evaluating coronary luminal stenosis using digital subtraction angiography as the standard of reference

    We sought to evaluate the accuracy of quantitative three-dimensional (3D) CT angiography (CTA) for the assessment of coronary luminal stenosis using digital subtraction angiography (DSA) as the standard of ref...

    Wei Guo, Xin Liu, Zhifan Gao, Sandeep Pirbhulal, Wenhua Huang, Wan-Hua Lin, Heye Zhang, Ning Tan and Yuan-Ting Zhang

    BioMedical Engineering OnLine 2015 14:50

    Published on: 30 May 2015