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BioMedical Engineering and the Heart

Coronary Blood Flow, Myocardial Perfusion, Myocardial Ischemia and Infarcts Detection, Customized Stents and Bypass Surgery

Dhanjoo Ghista and Kelvin Wong

Stents and bypass surgeries have become standard treatment for ischemic heart disease, a top cause of death worldwide. This BioMedical Engineering OnLine thematic series addresses the urgent scientific and clinical need to further investigate the dynamics of blood flow, occluded arteries, and structural variations contributing to myocardial ischemic regions. Doing so will help to unveil the mechanism underlying this disease and inspire technological advances that will improve diagnosis and treatment of coronary heart diseases.

The series focuses on computational analysis of the engineering, medical, and surgical aspects of cardiology, and welcomes submissions from these disciplines.

  1. Content type: Research

    This paper presents quantitative analysis of blood flow shear stress by measuring the carotid arterial wall shear stress (WSS) and the intima-media thickness (IMT) of experimental rabbits fed with high-fat fee...

    Authors: Bo Zhang, Junyi Gu, Ming Qian, Lili Niu, Hui Zhou and Dhanjoo Ghista

    Citation: BioMedical Engineering OnLine 2017 16:137

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  2. Content type: Research

    Spatial frequency domain (SFD) measurement allows rapid and non-contact wide-field imaging of the tissue optical properties, thus has become a potential tool for assessing physiological parameters and therapeu...

    Authors: Weiting Chen, Huijuan Zhao, Tongxin Li, Panpan Yan, Kuanxin Zhao, Caixia Qi and Feng Gao

    Citation: BioMedical Engineering OnLine 2017 16:100

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  3. Content type: Research

    The invasive fractional flow reserve has been considered the gold standard for identifying ischaemia-related stenosis in patients with suspected coronary artery disease. Determining non-invasive FFR based on c...

    Authors: Changzheng Shi, Dong Zhang, Kunlin Cao, Tao Zhang, Liangping Luo, Xin Liu and Heye Zhang

    Citation: BioMedical Engineering OnLine 2017 16:43

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  4. Content type: Review

    Cardiac dysfunction constitutes common cardiovascular health issues in the society, and has been an investigation topic of strong focus by researchers in the medical imaging community. Diagnostic modalities ba...

    Authors: Kelvin K. L. Wong, Defeng Wang, Jacky K. L. Ko, Jagannath Mazumdar, Thu-Thao Le and Dhanjoo Ghista

    Citation: BioMedical Engineering OnLine 2017 16:35

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  5. Content type: Research

    Haemodynamic performance of heart valve prosthesis can be defined as its ability to fully open and completely close during the cardiac cycle, neither overloading heart work nor damaging blood particles when p...

    Authors: Francesca Maria Susin, Stefania Espa, Riccardo Toninato, Stefania Fortini and Giorgio Querzoli

    Citation: BioMedical Engineering OnLine 2017 16:29

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  6. Content type: Research

    Since the electrocardiogram (ECG) signal has a low frequency and a weak amplitude, it is sensitive to miscellaneous mixed noises, which may reduce the diagnostic accuracy and hinder the physician’s correct dec...

    Authors: Oussama El B’charri, Rachid Latif, Khalifa Elmansouri, Abdenbi Abenaou and Wissam Jenkal

    Citation: BioMedical Engineering OnLine 2017 16:26

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  7. Content type: Research

    Although stents have great success of treating cardiovascular disease, it actually undermined by the in-stent restenosis and their long-term fatigue failure. The geometry of stent affects its service performan...

    Authors: Hongxia Li, Tao Liu, Minjie Wang, Danyang Zhao, Aike Qiao, Xue Wang, Junfeng Gu, Zheng Li and Bao Zhu

    Citation: BioMedical Engineering OnLine 2017 16:13

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  8. Content type: Research

    The goal of this paper is to present a computational fluid dynamic (CFD) model with moving boundaries to study the intraventricular flows in a patient-specific framework. Starting from the segmentation of real...

    Authors: A. M. Bavo, A. M. Pouch, J. Degroote, J. Vierendeels, J. H. Gorman, R. C. Gorman and P. Segers

    Citation: BioMedical Engineering OnLine 2016 15:107

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  9. Content type: Review

    Cardiovascular disease (CVD), the leading cause of death today, incorporates a wide range of cardiovascular system malfunctions that affect heart functionality. It is believed that the hemodynamic loads exerte...

    Authors: Siamak N. Doost, Dhanjoo Ghista, Boyang Su, Liang Zhong and Yosry S. Morsi

    Citation: BioMedical Engineering OnLine 2016 15:101

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  10. Content type: Research

    Misalignment in cardiac magnetic resonance (CMR) images can adversely affect three-dimensional left ventricle modelling and downstream quantitative analysis. Currently, there are two types of approaches for de...

    Authors: Min Wan, Wei Huang, Jun-Mei Zhang, Xiaodan Zhao, John Carson Allen, Ru San Tan, Xiaofeng Wan and Liang Zhong

    Citation: BioMedical Engineering OnLine 2016 15:93

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  11. Content type: Research

    Coronary hemodynamics and physiology specific for bifurcation lesions was not well understood. To investigate the influence of the bifurcation angle on the intracoronary hemodynamics of side branch (SB) lesion...

    Authors: Claudio Chiastra, Francesco Iannaccone, Maik J. Grundeken, Frank J. H. Gijsen, Patrick Segers, Matthieu De Beule, Patrick W. Serruys, Joanna J. Wykrzykowska, Antonius F. W. van der Steen and Jolanda J. Wentzel

    Citation: BioMedical Engineering OnLine 2016 15:91

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  12. Content type: Research

    Osseointegration refers to the direct connection between living bone and the surface of a load-bearing artificial implant. Porous implants with well-controlled porosity and pore size can enhance osseointegrati...

    Authors: Wei Peng, Liangwei Xu, Jia You, Lihua Fang and Qing Zhang

    Citation: BioMedical Engineering OnLine 2016 15:85

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  13. Content type: Research

    Blood oxygen saturation of vein (SvO2) is an important clinical parameter for patient monitoring. However, the existing clinical methods are invasive, expensive, which are also painful for patients.

    Authors: Xu Zhang, Meimei Zhang, Shengkun Zheng, Liqi Wang and Jilun Ye

    Citation: BioMedical Engineering OnLine 2016 15:84

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  14. Content type: Research

    Stress calculations in atherosclerotic coronary vulnerable plaques can aid in predicting coronary cap rupture. In vivo plaque geometry and composition of coronary arteries can merely be obtained via intravascu...

    Authors: Annette M. Kok, Lambert Speelman, Renu Virmani, Antonius F. W. van der Steen, Frank J. H. Gijsen and Jolanda J. Wentzel

    Citation: BioMedical Engineering OnLine 2016 15:48

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  15. Content type: Research

    Electrogram-guided ablation procedures have been proposed as an alternative strategy consisting of either mapping and ablating focal sources or targeting complex fractionated electrograms in atrial fibrillatio...

    Authors: Andres Orozco-Duque, John Bustamante and German Castellanos-Dominguez

    Citation: BioMedical Engineering OnLine 2016 15:44

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  16. Content type: Research

    Using of active cardiac medical devices increases steadily. In Europe, there were 183 implants of ICD and 944 implants of PM, 119 of biventricular ICD and 41 of biventricular PM, all per million inhabitants in...

    Authors: Martin Augustynek, David Korpas, Marek Penhaker, Jakub Cvek and Andrea Binarova

    Citation: BioMedical Engineering OnLine 2016 15:29

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  17. Content type: Research

    Areas with high frequency activity within the atrium are thought to be ‘drivers’ of the rhythm in patients with atrial fibrillation (AF) and ablation of these areas seems to be an effective therapy in eliminat...

    Authors: João L. Salinet, Nicholas Masca, Peter J. Stafford, G. André Ng and Fernando S. Schlindwein

    Citation: BioMedical Engineering OnLine 2016 15:28

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  18. Content type: Research

    Double injection of blood into cisterna magna using a rabbit model results in cerebral vasospasm. An unacceptably high mortality rate tends to limit the application of model. Ultrasound guided puncture can pro...

    Authors: Yongchao Chen, Youzhi Zhu, Yu Zhang, Zixuan Zhang, Juan Lian, Fucheng Luo, Xuefei Deng and Kelvin KL Wong

    Citation: BioMedical Engineering OnLine 2016 15:19

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  19. Content type: Research

    High blood pressure (BP) is among significant risk factor for stroke and other vascular occurrences, it experiences nonstop fluctuations over time as a result of a complex interface among cardiovascular contro...

    Authors: Yujie Chen, Huahua Xiong, Dan Wu, Sandeep Pirbhulal, Xiaohong Tian, Ruiqin Zhang, Minhua Lu, Wanqing Wu and Wenhua Huang

    Citation: BioMedical Engineering OnLine 2015 14:71

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  20. Content type: Research

    The dynamic expressions of monocyte chemo attractant protein-1 (MCP-1) and CC chamomile receptor 2 (CCR2) after balloon injury and their effects in intimal proliferation were discussed. In this study, the expr...

    Authors: Zhigang Huang, Yuebing Li, Lili Niu, Yang Xiao, Xiaodong Pu, Hairong Zheng and Ming Qian

    Citation: BioMedical Engineering OnLine 2015 14:55

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  21. Content type: Research

    We sought to evaluate the accuracy of quantitative three-dimensional (3D) CT angiography (CTA) for the assessment of coronary luminal stenosis using digital subtraction angiography (DSA) as the standard of ref...

    Authors: Wei Guo, Xin Liu, Zhifan Gao, Sandeep Pirbhulal, Wenhua Huang, Wan-Hua Lin, Heye Zhang, Ning Tan and Yuan-Ting Zhang

    Citation: BioMedical Engineering OnLine 2015 14:50

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