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Targeting cell death mechanisms in combination with radiotherapy

Dr Kirsten Lauber

  1. Research

    The SMAC mimetic BV6 sensitizes colorectal cancer cells to ionizing radiation by interfering with DNA repair processes and enhancing apoptosis

    In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in c...

    Stephanie Hehlgans, Julius Oppermann, Sebastian Reichert, Simone Fulda, Claus Rödel and Franz Rödel

    Radiation Oncology 2015 10:198

    Published on: 17 September 2015

  2. Research

    The in vitro immunogenic potential of caspase-3 proficient breast cancer cells with basal low immunogenicity is increased by hypofractionated irradiation

    Radiotherapy is an integral part of breast cancer treatment. Immune activating properties of especially hypofractionated irradiation are in the spotlight of clinicians, besides the well-known effects of radiot...

    Bernhard Kötter, Benjamin Frey, Markus Winderl, Yvonne Rubner, Heike Scheithauer, Renate Sieber, Rainer Fietkau and Udo S. Gaipl

    Radiation Oncology 2015 10:197

    Published on: 17 September 2015

  3. Research

    Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: data from in vitro and clinical pharmacokinetic studies in head and neck cancer

    Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apop...

    Shuraila F. Zerp, T. Rianne Stoter, Frank J. P. Hoebers, Michiel W. M. van den Brekel, Ria Dubbelman, Gitta K. Kuipers, M. Vincent M. Lafleur, Ben J. Slotman and Marcel Verheij

    Radiation Oncology 2015 10:158

    Published on: 30 July 2015

  4. Research

    Role of membrane Hsp70 in radiation sensitivity of tumor cells

    The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal...

    Naoya Murakami, Annett Kühnel, Thomas E. Schmid, Katarina Ilicic, Stefan Stangl, Isabella S. Braun, Mathias Gehrmann, Michael Molls, Jun Itami and Gabriele Multhoff

    Radiation Oncology 2015 10:149

    Published on: 22 July 2015

  5. Research

    High levels of X-linked Inhibitor-of-Apoptosis Protein (XIAP) are indicative of radio chemotherapy resistance in rectal cancer

    The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to downstage the tumour, allowing for more complete removal during surgery. In 40 % of cases however...

    L. Flanagan, J. Kehoe, J. Fay, O. Bacon, A.U. Lindner, E.W. Kay, J. Deasy, D.A. McNamara and J.H.M. Prehn

    Radiation Oncology 2015 10:131

    Published on: 13 June 2015

  6. Review

    Targeting IAP proteins in combination with radiotherapy

    The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radio...

    Simone Fulda

    Radiation Oncology 2015 10:105

    Published on: 26 April 2015

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