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Targeting cell death mechanisms in combination with radiotherapy

Dr Kirsten Lauber

  1. In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in c...

    Authors: Stephanie Hehlgans, Julius Oppermann, Sebastian Reichert, Simone Fulda, Claus Rödel and Franz Rödel

    Citation: Radiation Oncology 2015 10:198

    Content type: Research

    Published on:

  2. Radiotherapy is an integral part of breast cancer treatment. Immune activating properties of especially hypofractionated irradiation are in the spotlight of clinicians, besides the well-known effects of radiot...

    Authors: Bernhard Kötter, Benjamin Frey, Markus Winderl, Yvonne Rubner, Heike Scheithauer, Renate Sieber, Rainer Fietkau and Udo S. Gaipl

    Citation: Radiation Oncology 2015 10:197

    Content type: Research

    Published on:

  3. The quantitative analysis of foci plays an important role in many cell biological methods such as counting of colonies or cells, organelles or vesicles, or the number of protein complexes. In radiation biology...

    Authors: Sebastian Oeck, Nathalie M. Malewicz, Sebastian Hurst, Justine Rudner and Verena Jendrossek

    Citation: Radiation Oncology 2015 10:163

    Content type: Methodology

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  4. Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apop...

    Authors: Shuraila F. Zerp, T. Rianne Stoter, Frank J. P. Hoebers, Michiel W. M. van den Brekel, Ria Dubbelman, Gitta K. Kuipers, M. Vincent M. Lafleur, Ben J. Slotman and Marcel Verheij

    Citation: Radiation Oncology 2015 10:158

    Content type: Research

    Published on:

  5. The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal...

    Authors: Naoya Murakami, Annett Kühnel, Thomas E. Schmid, Katarina Ilicic, Stefan Stangl, Isabella S. Braun, Mathias Gehrmann, Michael Molls, Jun Itami and Gabriele Multhoff

    Citation: Radiation Oncology 2015 10:149

    Content type: Research

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  6. The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to downstage the tumour, allowing for more complete removal during surgery. In 40 % of cases however...

    Authors: L. Flanagan, J. Kehoe, J. Fay, O. Bacon, A.U. Lindner, E.W. Kay, J. Deasy, D.A. McNamara and J.H.M. Prehn

    Citation: Radiation Oncology 2015 10:131

    Content type: Research

    Published on:

  7. The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radio...

    Authors: Simone Fulda

    Citation: Radiation Oncology 2015 10:105

    Content type: Review

    Published on: