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Targeting cell death mechanisms in combination with radiotherapy

Dr Kirsten Lauber

  1. In the present study, we aimed to investigate the effect of counteracting inhibitor of apoptosis (IAP) proteins using the small molecule Second Mitochondria-derived Activator of Caspase (SMAC) mimetic BV6 in c...

    Authors: Stephanie Hehlgans, Julius Oppermann, Sebastian Reichert, Simone Fulda, Claus Rödel and Franz Rödel
    Citation: Radiation Oncology 2015 10:198
  2. Radiotherapy is an integral part of breast cancer treatment. Immune activating properties of especially hypofractionated irradiation are in the spotlight of clinicians, besides the well-known effects of radiot...

    Authors: Bernhard Kötter, Benjamin Frey, Markus Winderl, Yvonne Rubner, Heike Scheithauer, Renate Sieber, Rainer Fietkau and Udo S. Gaipl
    Citation: Radiation Oncology 2015 10:197
  3. The quantitative analysis of foci plays an important role in many cell biological methods such as counting of colonies or cells, organelles or vesicles, or the number of protein complexes. In radiation biology...

    Authors: Sebastian Oeck, Nathalie M. Malewicz, Sebastian Hurst, Justine Rudner and Verena Jendrossek
    Citation: Radiation Oncology 2015 10:163
  4. Pro-survival Bcl-2 family members can promote cancer development and contribute to treatment resistance. Head and neck squamous cell carcinoma (HNSCC) is frequently characterized by overexpression of anti-apop...

    Authors: Shuraila F. Zerp, T. Rianne Stoter, Frank J. P. Hoebers, Michiel W. M. van den Brekel, Ria Dubbelman, Gitta K. Kuipers, M. Vincent M. Lafleur, Ben J. Slotman and Marcel Verheij
    Citation: Radiation Oncology 2015 10:158
  5. The major stress-inducible heat shock protein 70 (Hsp70) is frequently overexpressed in the cytosol and integrated in the plasma membrane of tumor cells via lipid anchorage. Following stress such as non-lethal...

    Authors: Naoya Murakami, Annett Kühnel, Thomas E. Schmid, Katarina Ilicic, Stefan Stangl, Isabella S. Braun, Mathias Gehrmann, Michael Molls, Jun Itami and Gabriele Multhoff
    Citation: Radiation Oncology 2015 10:149
  6. The mainstay of treatment in rectal cancer is neoadjuvant radio chemotherapy prior to surgery, in an attempt to downstage the tumour, allowing for more complete removal during surgery. In 40 % of cases however...

    Authors: L. Flanagan, J. Kehoe, J. Fay, O. Bacon, A.U. Lindner, E.W. Kay, J. Deasy, D.A. McNamara and J.H.M. Prehn
    Citation: Radiation Oncology 2015 10:131
  7. The efficacy of radiotherapy critically depends on the activation of intrinsic cell death programs in cancer cells. This implies that evasion of cell death, a hallmark of human cancers, can contribute to radio...

    Authors: Simone Fulda
    Citation: Radiation Oncology 2015 10:105