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Myeloid suppressor cell therapy

The ONE Study is the acronym for a large scale collaborative project, entitled: "A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation", which is funded by the European Community's FP7. The project aims to improve treatments and the overall quality of life for kidney transplant patients through cell therapy. More specifically, the goal of the project is to develop and test an array of novel manufactured cell therapy products that have promise to reduce a kidney transplant patient's life-long dependency on immunosuppressive drugs. The ONE Study consortium explores the feasibility and potential of cell therapy in organ transplantation by bringing together experts to test different regulatory cell products composed of specific T cell (T regulatory cell, Treg and T regulatory type 1 cell, Tr1 cell), dendritic cell and macrophage subpopulations.

Besides the development and testing of regulatory cell populations in organ transplantation, a secondary aim of The ONE Study consortium is to comparatively study the regulatory mechanisms of different cell populations through workshops. Towards this aim, a ONE Study workshop on monocyte-derived suppressor cells was recently held in Regensburg, Germany. In preparing to assess the results of this workshop, the involved investigators deemed it useful to review the present literature on tolerogenic DCs and macrophage/myeloid derived suppressor cell populations. The authors of this review series consider the similarities and differences of these closely related cell populations, and suggest how they may best be applied as cell therapies meant to reduce organ transplant rejection. Indeed, cell therapy is entering a critical early phase of testing in transplantation, mandating that we take the necessary steps to determine which cell populations are most adaptable and effective for this purpose.

This review series in Transplantation Research offers a view into the future of cell therapy involving suppressive cells derived from readily available circulating monocytes. A more detailed introduction to the series can be found in the associated Editorial.

The research leading to these results has received funding from the European Union, Seventh Framework Programme [FP7/2007-2013], under grant agreement n° HEALTH-F5-2010-260687 The ONE Study.

  1. Content type: Review

    Several types of myeloid suppressor cell are currently being developed as cell-based immunosuppressive agents. Despite detailed knowledge about the molecular and cellular functions of these cell types, expert ...

    Authors: Paloma Riquelme, Edward K Geissler and James A Hutchinson

    Citation: Transplantation Research 2012 1:17

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  2. Content type: Review

    Organ transplantation is the main alternative to the loss of vital organ function from various diseases. However, to avoid graft rejection, transplant patients are treated with immunosuppressive drugs that hav...

    Authors: Aurélie Moreau, Emilie Varey, Laurence Bouchet-Delbos and Maria-Cristina Cuturi

    Citation: Transplantation Research 2012 1:13

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  3. Content type: Review

    In efforts to minimize the chronic administration of immunosuppression (IS) drugs in transplantation and autoimmune disease, various cell-based tolerogenic therapies, including the use of regulatory or tolerog...

    Authors: Camila Macedo, Hēth Turquist, Diana Metes and Angus W Thomson

    Citation: Transplantation Research 2012 1:16

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  4. Content type: Review

    Mesenchymal stem cells (MSC) mediate their immunosuppressive effects via a variety of mechanisms. One of these mechanisms involves the induction of macrophages with immunomodulatory capacities. This effect of ...

    Authors: Elke Eggenhofer and Martin J Hoogduijn

    Citation: Transplantation Research 2012 1:12

    Published on:

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