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25th Anniversary of the ICDS Cell Death collection

Cell Communication and Signaling is pleased to acknowledge and celebrate the 25-year anniversary of the International Cell Death Society (ICDS). In recognition of this milestone, the Editors of Cell Communication and Signaling have compiled a list of some of the important papers on cell death that have been published by the journal over the past decade. 

  1. In previous research, we found that lamprey immune protein (LIP) possessed cytocidal activity against tumor cells, but the mechanism of the selective recognition and killing of tumor cells by LIP was not ident...

    Authors: Yue Pang, Meng Gou, Kai Yang, Jiali Lu, Yinglun Han, Hongming Teng, Changzhi Li, Haina Wang, Caigang Liu, Kejia Zhang, Yongliang Yang and Qingwei Li
    Citation: Cell Communication and Signaling 2019 17:54
    Content type: Research Published on:

  2. Autophagy and ER stress are involved in maintaining some well-orchestrated mechanisms aimed at either restoring cellular homeostasis or performing cell death. Autophagy is a well-defined process which governs ...

    Authors: Wei Zheng, Weiwei Xie, Danyang Yin, Rui Luo, Min Liu and Fengjin Guo
    Citation: Cell Communication and Signaling 2019 17:42
    Content type: Research Published on:

  3. In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates f...

    Authors: Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca and Ciro Isidoro
    Citation: Cell Communication and Signaling 2019 17:39
    Content type: Research Published on:

  4. Deregulated c-Abl activity has been intensively studied in a variety of solid tumors and leukemia. The class-I carcinogen Helicobacter pylori (Hp) activates the non-receptor tyrosine kinase c-Abl to phosphorylate...

    Authors: Gernot Posselt, Maria Wiesauer, Bianca E. Chichirau, Daniela Engler, Linda M. Krisch, Gabriele Gadermaier, Peter Briza, Sabine Schneider, Francesco Boccellato, Thomas F. Meyer, Cornelia Hauser-Kronberger, Daniel Neureiter, Anne Müller and Silja Wessler
    Citation: Cell Communication and Signaling 2019 17:10
    Content type: Research Published on:

  5. Previously, several studies have shown that Tyro3, Axl, and Mertk (TAM) receptors participate in platelet activation and thrombosis. However, the role of individual receptors is not fully understood.

    Authors: Junsong Zhou, Aizhen Yang, Yucan Wang, Fengwu Chen, Zhenzhen Zhao, Viralkumar Davra, Katsue Suzuki-Inoue, Yukio Ozaki, Raymond B. Birge, Qingxian Lu and Yi Wu
    Citation: Cell Communication and Signaling 2018 16:98
    Content type: Research Published on:

  6. Depletion of tryptophan and the accumulation of tryptophan metabolites mediated by the immunosuppressive enzyme indoleamine 2,3-dioxygenase 1 (IDO1), trigger immune cells to undergo apoptosis. However, cancer ...

    Authors: Petr Tomek, Shanti K. Gore, Chloe L. Potts, Cristin G. Print, Michael A. Black, Ariane Hallermayr, Michael Kilian, Evelyn Sattlegger and Lai-Ming Ching
    Citation: Cell Communication and Signaling 2018 16:88
    Content type: Research Published on:

  7. Chemotherapeutic insensitivity remains a big challenge in prostate cancer treatment. Recently, increasing evidence has indicated that KLF4 plays a key role in prostate cancer. However, the potential biological...

    Authors: Lu Zhang, Xiaojie Li, Yulin Chao, Ruiping He, Junqiang Liu, Yi Yuan, Wenzhi Zhao, Chuanchun Han and Xishuang Song
    Citation: Cell Communication and Signaling 2018 16:53
    Content type: Research Published on:

    The Correction to this article has been published in Cell Communication and Signaling 2023 21:153

  8. CRM1 enrichment has been shown to be indicative of invasive as well as chemoresistant tumors. On the other hand, TRAIL, a powerful and specific anti-tumoral agent, has yet to be used effectively to treat gynec...

    Authors: François Fabi, Pascal Adam, Keven Vincent, Françis Demontigny, Sophie Parent, France-Hélène Joncas and Eric Asselin
    Citation: Cell Communication and Signaling 2018 16:39
    Content type: Research Published on:

  9. Programmed cell death protein 1 (PD-1), a negative co-stimulatory molecule, plays crucial roles in immune escape. Blockade of the interaction between PD-1 and PD-L1 shows exciting clinical responses in a fract...

    Authors: Jiangfeng Du, Yaping Qin, Yahong Wu, Wenshan Zhao, Wenjie Zhai, Yuanming Qi, Chuchu Wang and Yanfeng Gao
    Citation: Cell Communication and Signaling 2018 16:25
    Content type: Research Published on:

  11. Death receptor (DR5), a well-characterized death domain-containing cell surface pro-apoptotic protein, has been suggested to suppress cancer cell invasion and metastasis. However, the underlying mechanisms hav...

    Authors: You-Take Oh, Ping Yue and Shi-Yong Sun
    Citation: Cell Communication and Signaling 2017 15:18
    Content type: Research Published on:

  12. Renal cell carcinomas (RCCs) display broad resistance against conventional radio- and chemotherapies, which is due at least in part to impairments in both extrinsic and intrinsic apoptotic pathways. One import...

    Authors: Csaba Toth, Sarah Funke, Vanessa Nitsche, Anna Liverts, Viktoriya Zlachevska, Marcia Gasis, Constanze Wiek, Helmut Hanenberg, Csaba Mahotka, Peter Schirmacher and Sebastian Heikaus
    Citation: Cell Communication and Signaling 2017 15:16
    Content type: Research Published on:

  13. The immune system is capable of distinguishing between danger- and non-danger signals, thus inducing either an appropriate immune response against pathogens and cancer or inducing self-tolerance to avoid autoi...

    Authors: Kemal Catakovic, Eckhard Klieser, Daniel Neureiter and Roland Geisberger
    Citation: Cell Communication and Signaling 2017 15:1
    Content type: Review Published on:

  14. Tumor development and tumor progression is not only determined by the corresponding tumor cells but also by the tumor microenvironment. This includes an orchestrated network of interacting cell types (e.g. imm...

    Authors: Catharina Melzer, Yuanyuan Yang and Ralf Hass
    Citation: Cell Communication and Signaling 2016 14:20
    Content type: Review Published on:

  15. Cells of the tumor microenvironment are recognized as important determinants of the tumor biology. The adjacent non-malignant cells can regulate drug responses of the cancer cells by secreted paracrine factors...

    Authors: Svetlana Skolekova, Miroslava Matuskova, Martin Bohac, Lenka Toro, Erika Durinikova, Silvia Tyciakova, Lucia Demkova, Jan Gursky and Lucia Kucerova
    Citation: Cell Communication and Signaling 2016 14:4
    Content type: Research Published on:

    The Erratum to this article has been published in Cell Communication and Signaling 2016 14:7

  16. Hydrogen peroxide (H2O2) is involved in various signal transduction pathways and cell fate decisions. The mechanism of the so called “redox signaling” includes the H2O2-mediated reversible oxidation of redox sens...

    Authors: Claudia Lennicke, Jette Rahn, Rudolf Lichtenfels, Ludger A. Wessjohann and Barbara Seliger
    Citation: Cell Communication and Signaling 2015 13:39
    Content type: Review Published on:

  17. Mitochondria are key regulators of apoptosis. In response to stress, BH3-only proteins activate pro-apoptotic Bcl2 family proteins Bax and Bak, which induce mitochondrial outer membrane permeabilization (MOMP)...

    Authors: Sehyo Charley Choe, Anne Hamacher-Brady and Nathan Ryan Brady
    Citation: Cell Communication and Signaling 2015 13:37
    Content type: Research Published on:

  18. In many cells, bile acids (BAs) have a multitude of effects, some of which may be mediated by specific receptors such the TGR5 or FXR receptors. In pancreas systemic BAs, as well as intra-ductal BAs from bile ...

    Authors: Justyna M. Kowal, Kristian A. Haanes, Nynne M. Christensen and Ivana Novak
    Citation: Cell Communication and Signaling 2015 13:28
    Content type: Research Article Published on:

  19. Diabetes mellitus is a common metabolic disorder characterized by dysfunction of insulin-secreting pancreatic beta-cells. MicroRNAs are important regulators of beta-cell activities. These non-coding RNAs have ...

    Authors: Claudiane Guay, Véronique Menoud, Sophie Rome and Romano Regazzi
    Citation: Cell Communication and Signaling 2015 13:17
    Content type: Research Published on:

  20. Expression of programmed cell death ligand 1 (PD-L1) is an important process by which tumor cells suppress antitumor immunity in the tumor microenvironment. Bone marrow (BM)–derived immune cells are an importa...

    Authors: Hyangsoon Noh, Jiemiao Hu, Xiaohong Wang, Xueqing Xia, Arun Satelli and Shulin Li
    Citation: Cell Communication and Signaling 2015 13:14
    Content type: Research Published on:

  21. Mast cells (MCs) are major contributors to an inflammatory milieu. One of the most potent drivers of inflammation is the cytokine IL-1β, which is produced in the cytoplasm in response to danger signals like LP...

    Authors: Marcel Kuhny, Thomas Hochdörfer, Cemil Korcan Ayata, Marco Idzko and Michael Huber
    Citation: Cell Communication and Signaling 2014 12:40
    Content type: Research Published on:

  22. Numerous studies suggest energy failure and accumulative intracellular waste play a causal role in the pathogenesis of several neurodegenerative disorders and Alzheimer’s disease (AD) in particular. AD is char...

    Authors: Juan A Godoy, Juvenal A Rios, Juan M Zolezzi, Nady Braidy and Nibaldo C Inestrosa
    Citation: Cell Communication and Signaling 2014 12:23
    Content type: Review Published on:

  23. Platelet-derived growth factor (PDGF) isoforms and PDGF receptors have important functions in the regulation of growth and survival of certain cell types during embryonal development and e.g. tissue repair in the...

    Authors: Carl-Henrik Heldin
    Citation: Cell Communication and Signaling 2013 11:97
    Content type: Review Published on:

  24. Apoptosis is a form of programmed cell death, which is fundamental to all multicellular organisms. Deregulation of apoptosis leads to a number of severe diseases including cancer. Apoptosis is initiated either...

    Authors: Kolja Schleich and Inna N Lavrik
    Citation: Cell Communication and Signaling 2013 11:44
    Content type: Review Published on:

  25. The p53 protein is the best studied target in human cancer. For decades, p53 has been believed to act mainly as a tumor suppressor and by transcriptional regulation. Only recently, the complex and diverse func...

    Authors: Franziska Wachter, Michaela Grunert, Cristina Blaj, David M Weinstock, Irmela Jeremias and Harald Ehrhardt
    Citation: Cell Communication and Signaling 2013 11:27
    Content type: Research Published on:

  26. The determination of the cytotoxic potential of new and so far unknown compounds as well as their metabolites is fundamental in risk assessment. A variety of strategic endpoints have been defined to describe t...

    Authors: Philippe Wyrsch, Christian Blenn, Theresa Pesch, Sascha Beneke and Felix R Althaus
    Citation: Cell Communication and Signaling 2013 11:11
    Content type: Research Published on:

  28. Cytoplasmic viral double-stranded RNA (dsRNA) is detected by a class of ubiquitous cytoplasmic RNA helicases, retinoic acid inducible gene-I (RIG-I) and melanoma differentiation antigen-5 (MDA5), which initiat...

    Authors: Priya Handa, Joan C Tupper, Katherine C Jordan and John M Harlan
    Citation: Cell Communication and Signaling 2011 9:16
    Content type: Research Published on:

  29. The incidence of cancer in patients with neurological diseases, who have been treated with LiCl, is below average. LiCl is a well-established inhibitor of Glycogen synthase kinase-3, a kinase that controls sev...

    Authors: Larissa Kaufmann, Gabriela Marinescu, Irina Nazarenko, Wilko Thiele, Carolin Oberle, Jonathan Sleeman and Christine Blattner
    Citation: Cell Communication and Signaling 2011 9:15
    Content type: Research Published on:

  30. Embryonic stem cells (ESC) and induced pluripotent stem cells (iPSCs) present a great opportunity to treat and model human disease as a cell replacement therapy. There is a growing pressure to understand bette...

    Authors: Michael J Edel, Cristina Menchon, Jose MiguelAndres Vaquero and JuanCarlos Izpisua Belmonte
    Citation: Cell Communication and Signaling 2011 9:8
    Content type: Methodology Published on:

  31. The TNF receptor superfamily member CD95 (Fas, APO-1, TNFRSF6) is known as the prototypic death receptor in and outside the immune system. In fact, many mechanisms involved in apoptotic signaling cascades were...

    Authors: Maren Paulsen and Ottmar Janssen
    Citation: Cell Communication and Signaling 2011 9:7
    Content type: Debate Published on:

  32. The normal function of poly (ADP-ribose) polymerase-1 (PARP-1) is the routine repair of DNA damage by adding poly (ADP ribose) polymers in response to a variety of cellular stresses. Recently, it has become wi...

    Authors: Ganta Vijay Chaitanya, Jonathan S Alexander and Phanithi Prakash Babu
    Citation: Cell Communication and Signaling 2010 8:31
    Content type: Review Published on: