The study of cell biology of infection encompasses the complex interactions between the pathogens and host cells. Beyond its fundamental relevance, understanding the cellular and molecular processes underlying infection is also crucial for developing effective strategies to combat infectious diseases.
Recent technical advances (e.g. super-resolution microscopy and live cell imaging) have allowed researchers to visualize the dynamic interactions between pathogens and host cells in real time, providing insights into processes such as pathogen entry, intracellular survival, and host immune responses. In addition, high-throughput and single-cell omics technologies have enhanced the way we can study host-pathogen interactions and responses during infection.
In support of UN Sustainable Development Goal 3 (SDG 3, Good Health and Well-being), BMC Microbiology launches the collection, Cell biology of infection. This Collection aims to gather research focusing on host-pathogen interactions, mechanisms of cellular response to infection, and the development of host-directed therapies to combat bacterial and viral infections. We invite researchers and experts in the field to submit research articles that explore, but are not limited to, the following topics:
- Understanding how pathogens interact with host cells
- Mechanisms of viral infection and host response to viral invasion
- Host cellular interactions and responses against mycobacterial infections
- The impact of infection on normal cellular functions and processes
- Host cell metabolism reprogramming in response to viral and bacterial pathogen infections
- Host immune response to infection, and mechanisms used by pathogens to evade it
- Bacterial adaptation to the host environment and resistance to immune responses
- The role of inflammation in the host response to infection and its impact on cellular functions
- Membrane fusion, pore formation, membrane disruption, and viral entry
- Cellular signaling pathways during infection
- Cellular stress responses induced by infection and their impact on host-pathogen interactions
- Infection-induced cell death and its role in host defense
- Host-directed therapies to combat bacterial and viral infections
- Advanced flow cytometry as a tool to study host-pathogen interactions
- Multi-omics approaches to investigate host-pathogen interactions and responses during infection
- Single-cell RNA sequencing to study host-pathogen interactions
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