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Clinical Applications of Retinal Function Imager

Edited by Prof. Jianhua Wang 

Retinal function imager (RFI) is a versatile imaging system which was adapted in 2004 by Prof. Grinvald from the brain imaging technique. The RFI can image measure retinal blood flow velocity, create non-invasive capillary perfusion maps, and determine blood oximetry. The retinal capillary maps produced by RFI are similar to the en face view of the retinal capillary maps created by optical coherence tomography angiography (OCTA). Most importantly, the measurement of retinal blood flow velocity and flow volume in the small retinal vessels enables the estimate of the retinal tissue perfusion. This thematic series focuses on the recent applications of RFI and aims to publish review articles and original research of the latest discovery using RFI.

This series was published in Eye and Vision.

  1. Non-arteritic anterior ischemic optic neuropathy (NAION) is the most common cause of acute optic neuropathy in patients over 50 years of age, and many affected individuals are left with permanent visual defici...

    Authors: Amanda D. Henderson, Hong Jiang and Jianhua Wang
    Citation: Eye and Vision 2019 6:3
  2. It has been suggested that Sildenafil may have beneficial therapeutic effects in the treatment of neurodegenerative disorders. The retinal circulation is of significant interest as a marker of cerebral vascula...

    Authors: Asaf Achiron, Idan Hecht, Chen Juza, Adiel Barak and Zvia Burgansky-Eliash
    Citation: Eye and Vision 2018 5:30
  3. The retinal microcirculation has been studied in various diseases including multiple sclerosis (MS). However, inter-eye correlations and potential differences of the retinal blood flow velocity (BFV) remain la...

    Authors: Liang Wang, Ohemaa Kwakyi, James Nguyen, Esther Ogbuokiri, Olwen Murphy, Natalia Gonzalez Caldito, Laura Balcer, Elliot Frohman, Teresa Frohman, Peter A. Calabresi and Shiv Saidha
    Citation: Eye and Vision 2018 5:29
  4. The aim was to determine retinal nerve fiber layer function and its relations to retinal microvasculature and microcirculation in patients with myopia.

    Authors: Dongyi Qu, Ying Lin, Hong Jiang, Yi Shao, Yingying Shi, Shriya Airen, Giovanni Gregori and Jianhua Wang
    Citation: Eye and Vision 2018 5:25
  5. It remains unknow whether retinal tissue perfusion occurs in patients with Alzheimer’s disease. The goal was to determine retinal tissue perfusion in patients with clinical Alzheimer’s disease (CAD).

    Authors: Giovana Rosa Gameiro, Hong Jiang, Yi Liu, Yuqing Deng, Xiaoyan Sun, Bernardo Nascentes, Bernard Baumel, Tatjana Rundek and Jianhua Wang
    Citation: Eye and Vision 2018 5:21