Skip to main content

Cardiovascular disease: omics approaches and clinical applications

Guest Editors: James Ware and Connie Bezzina

Cardiovascular Diseases © freshidea / stock.adobe.comCardiovascular diseases remain a major cause of death and morbidity worldwide. Despite insight into the risk factors for cardiovascular conditions, disease mechanisms are incompletely understood. Unravelling the mechanisms of disease provides a deeper understanding of these conditions, with opportunities to develop novel therapies and improve treatment strategies. Furthermore, genetic and genomic biomarkers increasingly have direct application in patient management, through molecular diagnosis, prognostication, and therapeutic stratification, and this is a rapidly-evolving field for both common and rare forms of cardiovascular disease. Application of state-of-the-art techniques and technologies have provided insight into the fundamental functions across clinically relevant conditions, mechanisms underlying cardiovascular diseases and are valuable tools in clinical research and practice. 

In this special issue of Genome Medicine, guest edited by Prof James Ware from Imperial College London (UK), and Prof Connie Bezzina from Amsterdam (NL), we aim to capture advances that expand our knowledge of disease variation and aetiology, novel or improved tools for diagnosis and prognostics, as well as development of therapies and applications of genomics for precision healthcare. We are inviting the submission of Research, Method, Software and Guideline manuscripts with significant clinical and translational impact, in all areas of cardiovascular disease, including:

●    Mechanisms of cardiovascular function and disease
●    Clinical interpretation
●    Stem cell research
●    Therapies, including cellular and gene therapies
●    Disease modelling
●    Regenerative medicine and cardiac regeneration
●    Cardio-metabolic studies

We encourage work that fosters academic-industry partnerships and collaboration among scientists from multi-disciplinary fields.

To submit your manuscript, please use the Genome Medicine online submission system and indicate in your covering letter that you would like the article to be considered for the ‘Cardiovascular disease: omics approaches and clinical applications’ special issue. If you would like to enquire about the suitability of a manuscript for consideration, please email

This collection of articles has not been sponsored and articles will undergo the journal’s standard peer-review process. The Guest Editors declare that they have no competing interests. The Guest Editors serve an advisory role to guide the scope of the special issue and commissioned content; final editorial decisions lie with the Editor.

  1. The presence of coronary plaques with high-risk characteristics is strongly associated with adverse cardiac events beyond the identification of coronary stenosis. Testing by coronary computed tomography angiog...

    Authors: Peter Loof Møller, Palle Duun Rohde, Jonathan Nørtoft Dahl, Laust Dupont Rasmussen, Louise Nissen, Samuel Emil Schmidt, Victoria McGilligan, Daniel F. Gudbjartsson, Kari Stefansson, Hilma Holm, Jacob Fog Bentzon, Morten Bøttcher, Simon Winther and Mette Nyegaard
    Citation: Genome Medicine 2024 16:40
  2. Sudden unexpected death in children is a tragic event. Understanding the genetics of sudden death in the young (SDY) enables family counseling and cascade screening. The objective of this study was to characte...

    Authors: Megan J. Puckelwartz, Lorenzo L. Pesce, Edgar J. Hernandez, Gregory Webster, Lisa M. Dellefave-Castillo, Mark W. Russell, Sarah S. Geisler, Samuel D. Kearns, Felix Karthik, Susan P. Etheridge, Tanner O. Monroe, Tess D. Pottinger, Prince J. Kannankeril, M. Benjamin Shoemaker, Darlene Fountain, Dan M. Roden…
    Citation: Genome Medicine 2024 16:13
  3. Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular inj...

    Authors: Huiya Li, Pinyi Liu, Bing Zhang, Zengqiang Yuan, Mengdi Guo, Xinxin Zou, Yi Qian, Shiji Deng, Liwen Zhu, Xiang Cao, Tao Tao, Shengnan Xia, Xinyu Bao and Yun Xu
    Citation: Genome Medicine 2023 15:109
  4. Chronic limb-threatening ischemia (CLTI), a severe manifestation of peripheral arterial disease (PAD), is associated with a 1-year limb amputation rate of approximately 15–20% and substantial mortality. A key ...

    Authors: Kevin W. Southerland, Yueyuan Xu, Derek T. Peters, Xin Lin, Xiaolin Wei, Yu Xiang, Kaileen Fei, Lindsey A. Olivere, Jeremy M. Morowitz, James Otto, Qunsheng Dai, Christopher D. Kontos and Yarui Diao
    Citation: Genome Medicine 2023 15:95
  5. The immune response is a crucial factor for mediating the benefit of cardiac cell therapies. Our previous research showed that cardiomyocyte transplantation alters the cardiac immune response and, when combine...

    Authors: Praveen Vasudevan, Markus Wolfien, Heiko Lemcke, Cajetan Immanuel Lang, Anna Skorska, Ralf Gaebel, Anne-Marie Galow, Dirk Koczan, Tobias Lindner, Wendy Bergmann, Brigitte Mueller-Hilke, Brigitte Vollmar, Bernd Joachim Krause, Olaf Wolkenhauer, Gustav Steinhoff and Robert David
    Citation: Genome Medicine 2023 15:61