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Cardiovascular regeneration

Edited by Ronald Li

An article collection in Stem Cell Research & Therapy.

This series reviews the current state-of-the-art stem cell-based approaches for disease modeling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process. The Guest Editor and Editors declare no competing interests.

View all collections published in Stem Cell Research & Therapy

  1. Research

    Susceptibility of murine induced pluripotent stem cell-derived cardiomyocytes to hypoxia and nutrient deprivation

    Induced pluripotent stem cell-derived cardiomyocytes (iPS-CMs) may be suitable for myocardial repair. While their functional and structural properties have been extensively investigated, their response to isch...

    Andreja Brodarac, Tomo Šarić, Barbara Oberwallner, Shokoufeh Mahmoodzadeh, Klaus Neef, Julie Albrecht, Karsten Burkert, Matteo Oliverio, Filomain Nguemo, Yeong-Hoon Choi, Wolfram F Neiss, Ingo Morano, Jürgen Hescheler and Christof Stamm

    Stem Cell Research & Therapy 2015 6:83

    Published on: 23 April 2015

  2. Editorial

    Cardiovascular regeneration

    Heart disease remains the number one cause of death in developed countries. Loss of cardiomyocytes (CMs) due to aging or pathophysiological conditions (for example, myocardial infarction) is generally consider...

    Ronald A Li

    Stem Cell Research & Therapy 2014 5:141

    Published on: 17 December 2014

  3. Research

    Conjoint propagation and differentiation of human embryonic stem cells to cardiomyocytes in a defined microcarrier spinner culture

    Myocardial infarction is accompanied by a significant loss of cardiomyocytes (CMs). Functional CMs, differentiated from human embryonic stem cells (hESCs), offer a potentially unlimited cell source for cardiac...

    Alan Tin-Lun Lam, Allen Kuan-Liang Chen, Jian Li, William R Birch, Shaul Reuveny and Steve Kah-Weng Oh

    Stem Cell Research & Therapy 2014 5:110

    Published on: 15 September 2014

  4. Review

    Developmental cues for the maturation of metabolic, electrophysiological and calcium handling properties of human pluripotent stem cell-derived cardiomyocytes

    Human pluripotent stem cells (hPSCs), including embryonic and induced pluripotent stem cells, are abundant sources of cardiomyocytes (CMs) for cell replacement therapy and other applications such as disease mo...

    Wendy Keung, Kenneth R Boheler and Ronald A Li

    Stem Cell Research & Therapy 2014 5:17

    Published on: 28 January 2014

  5. Research

    Extracellular matrix remodeling following myocardial infarction influences the therapeutic potential of mesenchymal stem cells

    Although stem cell therapy is a promising treatment for myocardial infarction, the minimal functional improvements observed clinically limit its widespread application. A need exists to maximize the therapeuti...

    Kelly Elizabeth Sullivan, Kyle Patrick Quinn, Katherine Michele Tang, Irene Georgakoudi and Lauren Deems Black III

    Stem Cell Research & Therapy 2014 5:14

    Published on: 24 January 2014

  6. Review

    Considerations for pre-clinical models and clinical trials of pluripotent stem cell-derived cardiomyocytes

    Pluripotent stem cells (PSCs) represent an appealing source from which to develop cell replacement therapies. Different initiatives have been launched to promote their development toward clinical applications....

    Jean-Sébastien Hulot, Francesca Stillitano, Jo Elie Salem, Jason C Kovacic, Valentin Fuster and Roger J Hajjar

    Stem Cell Research & Therapy 2014 5:1

    Published on: 9 January 2014