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Cancer Stem Cells

  1. Research

    Regulation of stem-like cancer cells by glutamine through β-catenin pathway mediated by redox signaling

    Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang

    Molecular Cancer 2017 16:51

    Published on: 28 February 2017

  2. Review

    The epithelial to mesenchymal transition (EMT) and cancer stem cells: implication for treatment resistance in pancreatic cancer

    The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li

    Molecular Cancer 2017 16:52

    Published on: 28 February 2017

  3. Research

    ITIH5 mediates epigenetic reprogramming of breast cancer cells

    Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…

    Molecular Cancer 2017 16:44

    Published on: 23 February 2017

  4. Review

    Intra-tumor heterogeneity from a cancer stem cell perspective

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Pramudita R. Prasetyanti and Jan Paul Medema

    Molecular Cancer 2017 16:41

    Published on: 16 February 2017

  5. Review

    Mesenchymal stem cells: key players in cancer progression

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Molecular Cancer 2017 16:31

    Published on: 1 February 2017

  6. Research

    Metalloprotease-disintegrin ADAM12 actively promotes the stem cell-like phenotype in claudin-low breast cancer

    ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska

    Molecular Cancer 2017 16:32

    Published on: 1 February 2017

  7. Review

    Cancer stem cell niche models and contribution by mesenchymal stroma/stem cells

    The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass

    Molecular Cancer 2017 16:28

    Published on: 1 February 2017

  8. Review

    Epigenetics in cancer stem cells

    Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Molecular Cancer 2017 16:29

    Published on: 1 February 2017

  9. Research

    Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

    More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen

    Molecular Cancer 2017 16:30

    Published on: 1 February 2017

  10. Research

    Targeting CD133 improves chemotherapeutic efficacy of recurrent pediatric pilocytic astrocytoma following prolonged chemotherapy

    Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita

    Molecular Cancer 2017 16:21

    Published on: 31 January 2017

  11. Research

    Up-regulated NRIP2 in colorectal cancer initiating cells modulates the Wnt pathway by targeting RORβ

    Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu

    Molecular Cancer 2017 16:20

    Published on: 31 January 2017

  12. Short communication

    Interplay between CCR7 and Notch1 axes promotes stemness in MMTV-PyMT mammary cancer cells

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Molecular Cancer 2017 16:19

    Published on: 31 January 2017

  13. Review

    Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

    Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of...

    Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han and Ho Sung Kang

    Molecular Cancer 2017 16:10

    Published on: 30 January 2017

  14. Review

    Understanding of leukemic stem cells and their clinical implications

    Since leukemic stem cells (LSCs) or cancer stem cells (CSCs) were found in acute myeloid leukemia (AML) in 1997, extensive studies have been contributed to identification and characterization of such cell popu...

    Xuefei Wang, Shile Huang and Ji-Long Chen

    Molecular Cancer 2017 16:2

    Published on: 30 January 2017

  15. Review

    Targeting acute myeloid leukemia stem cell signaling by natural products

    Acute myeloid leukemia (AML) is the most commonly diagnosed leukemia in adults (25%) and comprises 15–20% in children. It is a genetically heterogeneous aggressive disease characterized by the accumulation of ...

    Kodappully Sivaraman Siveen, Shahab Uddin and Ramzi M. Mohammad

    Molecular Cancer 2017 16:13

    Published on: 30 January 2017

  16. Review

    The evolving concept of liver cancer stem cells

    Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Kouki Nio, Taro Yamashita and Shuichi Kaneko

    Molecular Cancer 2017 16:4

    Published on: 30 January 2017