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Cancer Stem Cells

  1. Content type: Review

    The mechanical properties of epithelial to mesenchymal transition (EMT) and a pancreatic cancer subpopulation with stem cell properties have been increasingly recognized as potent modulators of the effective o...

    Authors: Pingting Zhou, Bo Li, Furao Liu, Meichao Zhang, Qian Wang, Yuanhua Liu, Yuan Yao and Dong Li

    Citation: Molecular Cancer 2017 16:52

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  2. Content type: Research

    Cancer stem cells (CSCs) are thought to play an important role in tumor recurrence and drug resistance, and present a major challenge in cancer therapy. The tumor microenvironment such as growth factors, nutri...

    Authors: Jianwei Liao, Pan-Pan Liu, Guoxin Hou, Jiajia Shao, Jing Yang, Kaiyan Liu, Wenhua Lu, Shijun Wen, Yumin Hu and Peng Huang

    Citation: Molecular Cancer 2017 16:51

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  3. Content type: Research

    Extracellular matrix (ECM) is known to maintain epithelial integrity. In carcinogenesis ECM degradation triggers metastasis by controlling migration and differentiation including cancer stem cell (CSC) charact...

    Authors: Michael Rose, Vera Kloten, Erik Noetzel, Lukas Gola, Josef Ehling, Timon Heide, Steffen K. Meurer, Aljona Gaiko-Shcherbak, Antonio S. Sechi, Sebastian Huth, Ralf Weiskirchen, Oliver Klaas, Wiebke Antonopoulos, Qiong Lin, Wolfgang Wagner, Jürgen Veeck…

    Citation: Molecular Cancer 2017 16:44

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  4. Content type: Review

    It is widely believed that targeting the tumour-initiating cancer stem cell (CSC) component of malignancy has great therapeutic potential, particularly in therapy-resistant disease. However, despite concerted ...

    Authors: Claudia Gasch, Brendan Ffrench, John J. O’Leary and Michael F. Gallagher

    Citation: Molecular Cancer 2017 16:43

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  5. Content type: Review

    Tumor heterogeneity represents an ongoing challenge in the field of cancer therapy. Heterogeneity is evident between cancers from different patients (inter-tumor heterogeneity) and within a single tumor (intra...

    Authors: Pramudita R. Prasetyanti and Jan Paul Medema

    Citation: Molecular Cancer 2017 16:41

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  6. Content type: Review

    Most cancers contain a subpopulation of highly tumorigenic cells, known as cancer stem cells (CSCs) or tumor-initiating cells (TICs). Targeting TICs may be essential to achieve cure, because of their self-rene...

    Authors: Komal Qureshi-Baig, Pit Ullmann, Serge Haan and Elisabeth Letellier

    Citation: Molecular Cancer 2017 16:40

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  7. Content type: Research

    Homeobox genes are master regulators of cell fate during embryonic development and their expression is altered in cancer. By regulating the balance between cell proliferation and differentiation, they maintain...

    Authors: Mansi Shah, Ryan Cardenas, Belinda Wang, Jenny Persson, Nigel P. Mongan, Anna Grabowska and Cinzia Allegrucci

    Citation: Molecular Cancer 2017 16:38

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  8. Content type: Research

    ADAM12 is upregulated in human breast cancers and is a predictor of chemoresistance in estrogen receptor-negative tumors. ADAM12 is induced during epithelial-to-mesenchymal transition, a feature associated wit...

    Authors: Sara Duhachek-Muggy, Yue Qi, Randi Wise, Linda Alyahya, Hui Li, Jacob Hodge and Anna Zolkiewska

    Citation: Molecular Cancer 2017 16:32

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  9. Content type: Review

    Tumour progression is dependent on the interaction between tumour cells and cells of the surrounding microenvironment. The tumour is a dynamic milieu consisting of various cell types such as endothelial cells,...

    Authors: Sarah M. Ridge, Francis J. Sullivan and Sharon A. Glynn

    Citation: Molecular Cancer 2017 16:31

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  10. Content type: Research

    More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically...

    Authors: Parthasarathy Chandrakesan, Jiannan Yao, Dongfeng Qu, Randal May, Nathaniel Weygant, Yang Ge, Naushad Ali, Sripathi M. Sureban, Modhi Gude, Kenneth Vega, Eddie Bannerman-Menson, Lijun Xia, Michael Bronze, Guangyu An and Courtney W. Houchen

    Citation: Molecular Cancer 2017 16:30

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  11. Content type: Review

    Compelling evidence have demonstrated that bulk tumors can arise from a unique subset of cells commonly termed “cancer stem cells” that has been proposed to be a strong driving force of tumorigenesis and a key...

    Authors: Tan Boon Toh, Jhin Jieh Lim and Edward Kai-Hua Chow

    Citation: Molecular Cancer 2017 16:29

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  12. Content type: Review

    The initiation and progression of malignant tumors is driven by distinct subsets of tumor-initiating or cancer stem-like cells (CSCs) which develop therapy/apoptosis resistance and self-renewal capacity. In or...

    Authors: Catharina Melzer, Juliane von der Ohe, Hendrik Lehnert, Hendrik Ungefroren and Ralf Hass

    Citation: Molecular Cancer 2017 16:28

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  13. Content type: Research

    Pilocytic astrocytomas (PAs) are the most common pediatric central nervous system neoplasms. In the majority of cases these tumors are benign and receive favorable prognosis following gross total surgical rese...

    Authors: Guifa Xi, Yuping Derek Li, Gordan Grahovac, Veena Rajaram, Nitin Wadhwani, Tatiana Pundy, Barbara Mania-Farnell, Charles David James and Tadanori Tomita

    Citation: Molecular Cancer 2017 16:21

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  14. Content type: Research

    Colorectal cancer remains one of the most common malignant tumors worldwide. Colorectal cancer initiating cells (CCICs) are a small subpopulation responsible for malignant behaviors of colorectal cancer. Aberr...

    Authors: Zhenzhen Wen, Tianhui Pan, Saisai Yang, Jingwen Liu, Haiying Tao, Yiming Zhao, Dingting Xu, Wei Shao, Jia Wu, Xiyong Liu, Yongjiang Wang, Jianshan Mao and Yongliang Zhu

    Citation: Molecular Cancer 2017 16:20

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  15. Content type: Short communication

    Breast cancer is the major cause of cancer-related mortality in women. It is thought that quiescent stem-like cells within solid tumors are responsible for cancer maintenance, progression and eventual metastas...

    Authors: Sarah T. Boyle, Krystyna A. Gieniec, Carly E. Gregor, Jessica W. Faulkner, Shaun R. McColl and Marina Kochetkova

    Citation: Molecular Cancer 2017 16:19

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  16. Content type: Review

    Radiation therapy is one of the major tools of cancer treatment, and is widely used for a variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or indirectly via the generation of...

    Authors: Su Yeon Lee, Eui Kyong Jeong, Min Kyung Ju, Hyun Min Jeon, Min Young Kim, Cho Hee Kim, Hye Gyeong Park, Song Iy Han and Ho Sung Kang

    Citation: Molecular Cancer 2017 16:10

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  17. Content type: Review

    Epithelial-to-mesenchymal transition (EMT) is associated with metastasis formation as well as with generation and maintenance of cancer stem cells. In this way, EMT contributes to tumor invasion, heterogeneity...

    Authors: Davide Pradella, Chiara Naro, Claudio Sette and Claudia Ghigna

    Citation: Molecular Cancer 2017 16:8

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  18. Content type: Review

    The insulin-like growth factor-I (IGF-I) signaling induces epithelial to mesenchymal transition (EMT) program and contributes to metastasis and drug resistance in several subtypes of tumors. In preclinical stu...

    Authors: Heming Li, Izhar Singh Batth, Xiujuan Qu, Ling Xu, Na Song, Ruoyu Wang and Yunpeng Liu

    Citation: Molecular Cancer 2017 16:6

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  19. Content type: Review

    Liver cancer is an often fatal malignant tumor with a high recurrence rate and chemoresistance. The major malignant phenotypes of cancer, including recurrence, metastasis, and chemoresistance, are related to t...

    Authors: Kouki Nio, Taro Yamashita and Shuichi Kaneko

    Citation: Molecular Cancer 2017 16:4

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  20. Content type: Review

    Epithelial-mesenchymal transition (EMT) and cancer stem-like cells (CSC) are becoming highly relevant targets in anticancer drug discovery. A large body of evidence suggests that epithelial-mesenchymal transit...

    Authors: Fabrizio Marcucci, Pietro Ghezzi and Cristiano Rumio

    Citation: Molecular Cancer 2017 16:3

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