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Cancer imaging and new preclinical diagnostics in radiation oncology

Future perspectives in radiation oncology are built on new developments in cancer biology, improved radiation technology and enhanced imaging capabilities, with preclinical developments driving the clinic and vice versa. On the one hand, many existing techniques are more frequently used in radiotherapy for new, interesting purposes, such as the treatment planning or response assessment, whilst different functional and molecular imaging methods with corresponding biomarkers are currently being developed and characterized pre-clinically with the perspective of clinical translation. The aim of this collection of articles is to highlight the current state of the field and features a review article by Cyran and colleagues on Visualization, imaging and new preclinical diagnostics in radiation oncology.

Dr Maximilian Niyazi

  1. Research

    MRI and CT imaging for preoperative target volume delineation in breast-conserving therapy

    Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to serom...

    Mariska D den Hartogh, Marielle EP Philippens, Iris E van Dam, Catharina E Kleynen, Robbert JHA Tersteeg, Ruud M Pijnappel, Alexis NTJ Kotte, Helena M Verkooijen, Maurice AAJ van den Bosch, Marco van Vulpen, Bram van Asselen and HJG Desirée van den Bongard

    Radiation Oncology 2014 9:63

    Published on: 26 February 2014

  2. Research

    Deformable versus rigid registration of PET/CT images for radiation treatment planning of head and neck and lung cancer patients: a retrospective dosimetric comparison

    The purpose of this study is to evaluate the clinical impact of using deformable registration in tumor volume definition between separately acquired PET/CT and planning CT images.

    Dominique Fortin, Parminder S Basran, Tanya Berrang, David Peterson and Elaine S Wai

    Radiation Oncology 2014 9:50

    Published on: 10 February 2014

  3. Research

    Pretreatment SUVmax predicts progression-free survival in early-stage non-small cell lung cancer treated with stereotactic body radiation therapy

    This retrospective study aims to assess the usefulness of SUVmax from FDG-PET imaging as a prognosticator for primary biopsy-proven stage I NSCLC treated with SBRT.

    Zachary D Horne, David A Clump, John A Vargo, Samir Shah, Sushil Beriwal, Steven A Burton, Annette E Quinn, Matthew J Schuchert, Rodney J Landreneau, Neil A Christie, James D Luketich and Dwight E Heron

    Radiation Oncology 2014 9:41

    Published on: 30 January 2014

  4. Research

    Investigation of variability in image acquisition and contouring during 3D ultrasound guidance for partial breast irradiation

    Three-dimensional ultrasound (3DUS) at simulation compared to 3DUS at treatment is an image guidance option for partial breast irradiation (PBI). This study assessed if user dependence in acquiring and contour...

    Anthony Landry, Tanya Berrang, Isabelle Gagne, Carmen Popescu, Tracy Mitchell, Hazel Vey, Letricia Sand, Siew Yan Soh, Jill Wark, Ivo Olivotto and Wayne Beckham

    Radiation Oncology 2014 9:35

    Published on: 27 January 2014

  5. Research

    Change in prostate volume during extreme hypo-fractionation analysed with MRI

    Hypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension dur...

    Adalsteinn Gunnlaugsson, Elisabeth Kjellén, Oskar Hagberg, Camilla Thellenberg-Karlsson, Anders Widmark and Per Nilsson

    Radiation Oncology 2014 9:22

    Published on: 13 January 2014

  6. Study protocol

    MR-guidance – a clinical study to evaluate a shuttle- based MR-linac connection to provide MR-guided radiotherapy

    The purpose of this clinical study is to investigate the clinical feasibility and safety of a shuttle-based MR-linac connection to provide MR-guided radiotherapy.

    Tilman Bostel, Nils H Nicolay, Jörg G Grossmann, Angela Mohr, Stefan Delorme, Gernot Echner, Peter Häring, Jürgen Debus and Florian Sterzing

    Radiation Oncology 2014 9:12

    Published on: 9 January 2014

  7. Research

    Adequacy of inhale/exhale breathhold CT based ITV margins and image-guided registration for free-breathing pancreas and liver SBRT

    To evaluate use of breath-hold CTs and implanted fiducials for definition of the internal target volume (ITV) margin for upper abdominal stereotactic body radiation therapy (SBRT). To study the statistics of i...

    Wensha Yang, Benedick A Fraass, Robert Reznik, Nicholas Nissen, Simon Lo, Laith H Jamil, Kapil Gupta, Howard Sandler and Richard Tuli

    Radiation Oncology 2014 9:11

    Published on: 9 January 2014

  8. Research

    A criterion for the reliable use of MRI-only radiotherapy

    MRI-only radiotherapy will eliminate the systematic registration errors introduced when transferring MRI information to the CT. However, challenges concerning the missing information on electron density, neces...

    Marie E Korsholm, Line W Waring and Jens M Edmund

    Radiation Oncology 2014 9:16

    Published on: 9 January 2014

  9. Review

    Visualization, imaging and new preclinical diagnostics in radiation oncology

    Innovative strategies in cancer radiotherapy are stimulated by the growing knowledge on cellular and molecular tumor biology, tumor pathophysiology, and tumor microenvironment. In terms of tumor diagnostics an...

    Clemens C Cyran, Philipp M Paprottka, Michel Eisenblätter, Dirk A Clevert, Carsten Rist, Konstantin Nikolaou, Kirsten Lauber, Frederik Wenz, Daniel Hausmann, Maximilian F Reiser, Claus Belka and Maximilian Niyazi

    Radiation Oncology 2014 9:3

    Published on: 3 January 2014

  10. Research

    3 Tesla multiparametric MRI for GTV-definition of Dominant Intraprostatic Lesions in patients with Prostate Cancer – an interobserver variability study

    To evaluate the interobserver variability of gross tumor volume (GTV) - delineation of Dominant Intraprostatic Lesions (DIPL) in patients with prostate cancer using published MRI criteria for multiparametric M...

    Hans Christian Rischke, Ursula Nestle, Tobias Fechter, Christian Doll, Natalja Volegova-Neher, Karl Henne, Jutta Scholber, Stefan Knippen, Simon Kirste, Anca L Grosu and Cordula A Jilg

    Radiation Oncology 2013 8:183

    Published on: 22 July 2013

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