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Cancer imaging and new preclinical diagnostics in radiation oncology

Future perspectives in radiation oncology are built on new developments in cancer biology, improved radiation technology and enhanced imaging capabilities, with preclinical developments driving the clinic and vice versa. On the one hand, many existing techniques are more frequently used in radiotherapy for new, interesting purposes, such as the treatment planning or response assessment, whilst different functional and molecular imaging methods with corresponding biomarkers are currently being developed and characterized pre-clinically with the perspective of clinical translation. The aim of this collection of articles is to highlight the current state of the field and features a review article by Cyran and colleagues on Visualization, imaging and new preclinical diagnostics in radiation oncology.

Dr Maximilian Niyazi

  1. Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to serom...

    Authors: Mariska D den Hartogh, Marielle EP Philippens, Iris E van Dam, Catharina E Kleynen, Robbert JHA Tersteeg, Ruud M Pijnappel, Alexis NTJ Kotte, Helena M Verkooijen, Maurice AAJ van den Bosch, Marco van Vulpen, Bram van Asselen and HJG Desirée van den Bongard
    Citation: Radiation Oncology 2014 9:63
  2. The purpose of this study is to evaluate the clinical impact of using deformable registration in tumor volume definition between separately acquired PET/CT and planning CT images.

    Authors: Dominique Fortin, Parminder S Basran, Tanya Berrang, David Peterson and Elaine S Wai
    Citation: Radiation Oncology 2014 9:50
  3. This retrospective study aims to assess the usefulness of SUVmax from FDG-PET imaging as a prognosticator for primary biopsy-proven stage I NSCLC treated with SBRT.

    Authors: Zachary D Horne, David A Clump, John A Vargo, Samir Shah, Sushil Beriwal, Steven A Burton, Annette E Quinn, Matthew J Schuchert, Rodney J Landreneau, Neil A Christie, James D Luketich and Dwight E Heron
    Citation: Radiation Oncology 2014 9:41
  4. Three-dimensional ultrasound (3DUS) at simulation compared to 3DUS at treatment is an image guidance option for partial breast irradiation (PBI). This study assessed if user dependence in acquiring and contour...

    Authors: Anthony Landry, Tanya Berrang, Isabelle Gagne, Carmen Popescu, Tracy Mitchell, Hazel Vey, Letricia Sand, Siew Yan Soh, Jill Wark, Ivo Olivotto and Wayne Beckham
    Citation: Radiation Oncology 2014 9:35
  5. Hypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension dur...

    Authors: Adalsteinn Gunnlaugsson, Elisabeth Kjellén, Oskar Hagberg, Camilla Thellenberg-Karlsson, Anders Widmark and Per Nilsson
    Citation: Radiation Oncology 2014 9:22
  6. MRI-only radiotherapy will eliminate the systematic registration errors introduced when transferring MRI information to the CT. However, challenges concerning the missing information on electron density, neces...

    Authors: Marie E Korsholm, Line W Waring and Jens M Edmund
    Citation: Radiation Oncology 2014 9:16
  7. The purpose of this clinical study is to investigate the clinical feasibility and safety of a shuttle-based MR-linac connection to provide MR-guided radiotherapy.

    Authors: Tilman Bostel, Nils H Nicolay, Jörg G Grossmann, Angela Mohr, Stefan Delorme, Gernot Echner, Peter Häring, Jürgen Debus and Florian Sterzing
    Citation: Radiation Oncology 2014 9:12
  8. To evaluate use of breath-hold CTs and implanted fiducials for definition of the internal target volume (ITV) margin for upper abdominal stereotactic body radiation therapy (SBRT). To study the statistics of i...

    Authors: Wensha Yang, Benedick A Fraass, Robert Reznik, Nicholas Nissen, Simon Lo, Laith H Jamil, Kapil Gupta, Howard Sandler and Richard Tuli
    Citation: Radiation Oncology 2014 9:11
  9. Innovative strategies in cancer radiotherapy are stimulated by the growing knowledge on cellular and molecular tumor biology, tumor pathophysiology, and tumor microenvironment. In terms of tumor diagnostics an...

    Authors: Clemens C Cyran, Philipp M Paprottka, Michel Eisenblätter, Dirk A Clevert, Carsten Rist, Konstantin Nikolaou, Kirsten Lauber, Frederik Wenz, Daniel Hausmann, Maximilian F Reiser, Claus Belka and Maximilian Niyazi
    Citation: Radiation Oncology 2014 9:3
  10. To evaluate the interobserver variability of gross tumor volume (GTV) - delineation of Dominant Intraprostatic Lesions (DIPL) in patients with prostate cancer using published MRI criteria for multiparametric M...

    Authors: Hans Christian Rischke, Ursula Nestle, Tobias Fechter, Christian Doll, Natalja Volegova-Neher, Karl Henne, Jutta Scholber, Stefan Knippen, Simon Kirste, Anca L Grosu and Cordula A Jilg
    Citation: Radiation Oncology 2013 8:183