The identification of genes related to cancer origin and progression has been greatly expanded with the establishment of The Cancer Genome Atlas (TCGA) and of the Pan-Cancer Analysis of Whole Genomes (PCAWG) consortia, which include most tumor types, matching DNA sequencing, and RNA transcripts. As a result, we now have a better grasp of the molecular pathways underlying cancer, its biochemistry, and, therefore, new therapeutic targets.
In this Collection, we aim to showcase scientific papers which describe distinct aspects of the molecular mechanisms involved in cancer development and progression, as well as its liaison with new potential therapeutic interventions. We describe distinct aspects of precision oncology, the ability to stratify patients with distinct prognostic features and therapeutic requirements, as well as its liaison with the current complexity of the underlying molecular mechanisms.