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Hypertension, preeclampsia, renal and cardiovascular disease in pregnancy

This collection in Biology of Sex Differences, featuring original research and short review articles, focuses on associative, mechanistic, and translational studies linking pregnancy, pregnancy hypertension, preeclampsia, renal and cardiovascular diseases as they relate to pregnancy outcomes, placental factors, development of hypertension, congenital diseases and adverse fetal outcomes. The editors encourage submission of both basic science research using animal models and clinically relevant translational studies involving human subjects.

  1. Two important clinical features of preeclampsia (PE) are hypertension and fetal growth restriction. The reduced uterine perfusion pressure (RUPP) preclinical rat model of PE exhibits both of these features. Mo...

    Authors: Mark W. Cunningham Jr, Lorena M. Amaral, Nathan E. Campbell, Denise C. Cornelius, Tarek Ibrahim, Venkata Ramana Vaka and Babbette LaMarca

    Citation: Biology of Sex Differences 2021 12:4

    Content type: Research

    Published on:

  2. The incidence of acute kidney injury (AKI) during pregnancy precedes a high maternal mortality rate of 20–40%. AKI during pregnancy has multiple etiologies; however, the more common are maternal hypertensive d...

    Authors: Jamie Szczepanski, Shauna-Kay Spencer, Ashley Griffin, Teylor Bowles, Jan Michael Williams, Patrick B. Kyle, John Polk Dumas, Sarah Araji and Kedra Wallace

    Citation: Biology of Sex Differences 2020 11:54

    Content type: Research

    Published on:

  3. Studies have recently examined the role of epigenetic mechanisms in preeclampsia pathophysiology. One commonly examined epigenetic process is DNA methylation. This heritable epigenetic marker is involved in ma...

    Authors: A. Cirkovic, V. Garovic, J. Milin Lazovic, O. Milicevic, M. Savic, N. Rajovic, N. Aleksic, T. Weissgerber, A. Stefanovic, D. Stanisavljevic and N. Milic

    Citation: Biology of Sex Differences 2020 11:36

    Content type: Review

    Published on:

  4. Since the placenta also has a sex, fetal sex–specific differences in the occurrence of placenta-mediated complications could exist.

    Authors: Zoe A. Broere-Brown, Maria C. Adank, Laura Benschop, Myrte Tielemans, Taulant Muka, Romy Gonçalves, Wichor M. Bramer, Josje D Schoufour, Trudy Voortman, Eric A. P. Steegers, Oscar H. Franco and Sarah Schalekamp-Timmermans

    Citation: Biology of Sex Differences 2020 11:26

    Content type: Review

    Published on:

  5. Placental ischemia and hypertension, characteristic features of preeclampsia, are associated with impaired cerebral blood flow (CBF) autoregulation and cerebral edema. However, the factors that contribute to t...

    Authors: Junie P. Warrington, Fan Fan, Jeremy Duncan, Mark W. Cunningham, Babette B. LaMarca, Ralf Dechend, Gerd Wallukat, Richard J. Roman, Heather A. Drummond, Joey P. Granger and Michael J. Ryan

    Citation: Biology of Sex Differences 2019 10:58

    Content type: Research

    Published on:

  6. Exposure to air pollution and high levels of noise have both been independently associated with the development of adverse pregnancy outcomes including low birth weight. However, exposure to such environmental...

    Authors: Colette N. Miller, Urmila P. Kodavanti, Erica J. Stewart, Mette C. Schladweiler, Judy H. Richards, Samantha J. Snow, Andres R. Henriquez, Wendy M. Oshiro, Aimen K. Farraj, Mehdi S. Hazari and Janice A. Dye

    Citation: Biology of Sex Differences 2019 10:54

    Content type: Research

    Published on:

  7. Preeclampsia is a pregnancy-specific hypertensive disorder characterized by impaired angiogenesis. We postulate that senescence of mesenchymal stem cells (MSC), multipotent cells with pro-angiogenic activities...

    Authors: Sonja Suvakov, Hajrunisa Cubro, Wendy M. White, Yvonne S. Butler Tobah, Tracey L. Weissgerber, Kyra L. Jordan, Xiang Y. Zhu, John R. Woollard, Fouad T. Chebib, Natasa M. Milic, Joseph P. Grande, Ming Xu, Tamara Tchkonia, James L. Kirkland, Lilach O. Lerman and Vesna D. Garovic

    Citation: Biology of Sex Differences 2019 10:49

    Content type: Research

    Published on:

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