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Bravecto TM

This article collection page focusing on Bravecto™ (fluranaler) was created to facilitate access to articles published in Parasites & Vectors relating to this topic. The article processing charges for the articles in the collection have been funded by MSD Animal Health and a detailed conflict of interest statement is included within each article. The articles in this collection have undergone the journal’s standard peer-review process and each article can also be found individually in the journal.

Non-English translations of some articles in this collection can be viewed here

Collection published: 6 March 2014

View all collections published in Parasites & Vectors


  1. Research

    Assessment of dog owner adherence to veterinarians’ flea and tick prevention recommendations in the United States using a cross-sectional survey

    Adherence to a prescribed therapeutic regimen is a critical factor for achieving medication effectiveness and therefore treatment success. In the case of companion animal ectoparasite control, suboptimal owner...

    Robert P. Lavan, Kaan Tunceli, Dongmu Zhang, Dorothy Normile and Rob Armstrong

    Parasites & Vectors 2017 10:284

    Published on: 6 June 2017

  2. Research

    A comparative laboratory trial evaluating the immediate efficacy of fluralaner, afoxolaner, sarolaner and imidacloprid + permethrin against adult Rhipicephalus sanguineus (sensu lato) ticks attached to dogs

    Acaricides are used to treat and prevent tick infestations, and a common clinical scenario is to administer an acaricide on observing an attached tick. Consequently, immediate acaricidal efficacy (onset of act...

    Federica Burgio, Leon Meyer and Rob Armstrong

    Parasites & Vectors 2016 9:626

    Published on: 3 December 2016

  3. Research

    Efficacy of fluralaner administered either orally or topically for the treatment of naturally acquired Sarcoptes scabiei var. canis infestation in dogs

    The efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. canis infestation in dogs.

    Janina Taenzler, Julian Liebenberg, Rainer K. A. Roepke, Régis Frénais and Anja R. Heckeroth

    Parasites & Vectors 2016 9:392

    Published on: 7 July 2016

  4. Research

    Evaluation of fluralaner and afoxolaner treatments to control flea populations, reduce pruritus and minimize dermatologic lesions in naturally infested dogs in private residences in west central Florida USA

    A study was conducted to evaluate and compare the effectiveness of two different oral flea and tick products to control flea infestations, reduce pruritus and minimize dermatologic lesions over a 12 week perio...

    Michael W. Dryden, Michael S. Canfield, Kimberly Kalosy, Amber Smith, Lisa Crevoiserat, Jennifer C. McGrady, Kaitlin M. Foley, Kathryn Green, Chantelle Tebaldi, Vicki Smith, Tashina Bennett, Kathleen Heaney, Lisa Math, Christine Royal and Fangshi Sun

    Parasites & Vectors 2016 9:365

    Published on: 28 June 2016

  5. Short report

    Safety of concurrent treatment of cats with fluralaner and emodepsid–praziquantel

    Fluralaner is a novel systemic ectoparasiticide for cats providing immediate and persistent flea- and tick-control after a single topical dose. Emodepsid and praziquantel are routinely used to control intestin...

    Feli M. Walther, Mark J. Allan and Rainer K. A. Roepke

    Parasites & Vectors 2016 9:322

    Published on: 6 June 2016

    The Erratum to this article has been published in Parasites & Vectors 2016 9:366

  6. Research

    Efficacy of fluralaner spot-on solution against induced infestations with Rhipicephalus sanguineus on dogs

    The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period.

    Janina Taenzler, Julian Liebenberg, Machiel Mienie, William R. Everett, David R. Young, Thomas S. Vihtelic, Fangshi Sun, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth

    Parasites & Vectors 2016 9:276

    Published on: 31 May 2016

  7. Research

    The effect of water and shampooing on the efficacy of fluralaner spot-on solution against Ixodes ricinus and Ctenocephalides felis infestations in dogs

    Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. The active ingredient fluralaner is dis...

    Janina Taenzler, Boyd Gale, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth

    Parasites & Vectors 2016 9:233

    Published on: 31 May 2016

  8. Research

    Open field study on the efficacy of oral fluralaner for long-term control of flea allergy dermatitis in client-owned dogs in Ile-de-France region

    Fluralaner is the first orally administered isoxazoline to provide 12 weeks of activity against fleas and ticks after a single administration. As a result of its potent anti-flea activity, oral fluralaner may ...

    Odile Crosaz, Elodie Chapelle, Noëlle Cochet-Faivre, Diane Ka, Céline Hubinois and Jacques Guillot

    Parasites & Vectors 2016 9:174

    Published on: 23 March 2016

  9. Research

    Efficacy of fluralaner flavored chews (Bravecto®) administered to dogs against the adult cat flea, Ctenocephalides felis felis and egg production

    Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against ...

    Michael W Dryden, Vicki Smith, Tashina Bennett, Lisa Math, James Kallman, Kathleen Heaney and Fangshi Sun

    Parasites & Vectors 2015 8:364

    Published on: 11 July 2015

    The Erratum to this article has been published in Parasites & Vectors 2015 8:405

  10. Research

    A quantitative evaluation of the extent of fluralaner uptake by ticks (Ixodes ricinus, Ixodes scapularis) in fluralaner (BravectoTM) treated vs. untreated dogs using the parameters tick weight and coxal index

    Fluralaner is a new antiparasitic drug that was recently introduced as BravectoTM chewable tablets for the treatment of tick and flea infestations in dogs. Most marketed tick products exert their effect via topic...

    Heike Williams, Janina Demeler, Janina Taenzler, Rainer K.A. Roepke, Eva Zschiesche and Anja R. Heckeroth

    Parasites & Vectors 2015 8:352

    Published on: 30 June 2015

  11. Research

    Efficacy of orally administered fluralaner (BravectoTM) or topically applied imidacloprid/moxidectin (Advocate®) against generalized demodicosis in dogs

    This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against ...

    Josephus J Fourie, Julian E Liebenberg, Ivan G Horak, Janina Taenzler, Anja R Heckeroth and Regis Frénais

    Parasites & Vectors 2015 8:187

    Published on: 28 March 2015

  12. Research

    Fluralaner activity against life stages of ticks using Rhipicephalus sanguineus and Ornithodoros moubata IN in vitro contact and feeding assays

    Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the suscept...

    Heike Williams, Hartmut Zoller, Rainer KA Roepke, Eva Zschiesche and Anja R Heckeroth

    Parasites & Vectors 2015 8:90

    Published on: 8 February 2015

  13. Research

    Onset of activity of fluralaner (BRAVECTO™) against Ctenocephalides felis on dogs

    Fluralaner (Bravecto™) is a novel systemic insecticide and acaricide that provides long persistent antiparasitic activity following a single administration at the minimum dose of 25 mg/kg body weight.

    Janina Taenzler, Christina Wengenmayer, Heike Williams, Josephus Fourie, Eva Zschiesche, Rainer KA Roepke and Anja R Heckeroth

    Parasites & Vectors 2014 7:567

    Published on: 4 December 2014

  14. Research

    The speed of kill of fluralaner (Bravecto™) against Ixodes ricinus ticks on dogs

    Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to preven...

    Christina Wengenmayer, Heike Williams, Eva Zschiesche, Andreas Moritz, Judith Langenstein, Rainer KA Roepke and Anja R Heckeroth

    Parasites & Vectors 2014 7:525

    Published on: 18 November 2014

  15. Research

    Fluralaner, a novel isoxazoline, prevents flea (Ctenocephalides felis) reproduction in vitro and in a simulated home environment

    Fluralaner, a novel isoxazoline, has both acaricidal and insecticidal activity through potent blockage of GABA- and L-glutamate-gated chloride channels. This study investigated the in vitro and in vivo effects of...

    Heike Williams, David R Young, Tariq Qureshi, Hartmut Zoller and Anja R Heckeroth

    Parasites & Vectors 2014 7:275

    Published on: 19 June 2014

  16. Short report

    Safety of the concurrent treatment of dogs with Bravecto™ (fluralaner) and Scalibor™ protectorband (deltamethrin)

    Bravecto™ (fluralaner; MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Scalibor™ Protectorband (deltamethrin; MSD Animal ...

    Feli M Walther, Petr Fisara, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Parasites & Vectors 2014 7:105

    Published on: 19 March 2014

  17. Research

    The effect of food on the pharmacokinetics of oral fluralaner in dogs

    Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. T...

    Feli M Walther, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Parasites & Vectors 2014 7:84

    Published on: 5 March 2014

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