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Bravecto®

This article collection page focusing on Bravecto® (fluranaler) was created to facilitate access to articles published in Parasites & Vectors relating to this topic. The article processing charges for the articles in the collection have been funded by MSD Animal Health and a detailed conflict of interest statement is included within each article. The articles in this collection have undergone the journal’s standard peer-review process and each article can also be found individually in the journal.

Non-English translations of some articles in this collection can be viewed here. 

Collection published: 6 March 2014

View all collections published in Parasites & Vectors




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  1. The isoxazoline fluralaner is effective for prevention of Babesia canis transmission from infected Dermacentor reticulatus ticks to dogs for 84 days in a controlled environment. This study was designed to evaluat...

    Authors: Rafael Chiummo, Eva Zschiesche, Balázs Capári, Róbert Farkas, Mathieu Chiquet, Dhimitër Rapti, Rezart Postoli, Alain Audry and Michael Leschnik
    Citation: Parasites & Vectors 2023 16:252
    Content type: Research Published on:

  2. This study evaluated the timing of dog owner ectoparasiticide purchases to estimate administration compliance and assess the consequent impact of dose purchase gaps on the proportion of time that dogs were pro...

    Authors: Robert Lavan, Dorothy Normile, Imran Husain, Amita Singh, Rob Armstrong and Kathleen Heaney
    Citation: Parasites & Vectors 2022 15:32
    Content type: Research Published on:

  3. Triatomines are responsible for the vector transmission of the protozoan parasite Trypanosoma cruzi, which causes Chagas disease. Triatoma brasiliensis is the main vector of the parasite in Brazil, and dogs are a...

    Authors: Tamyres Bernadete Dantas Queiroga, Luanderson Cardoso Pereira Gomez, Eduardo Rodrigues de Sena, Wilo Victor dos Santos, Henrique Rafael Pontes Ferreira, Vicente Toscano de Araújo-Neto, Andressa Noronha Barbosa-Silva, Carlos Ramon do Nascimento Brito, Romeika Karla dos Reis Lima, João Ciro Fagundes-Neto, Lúcia Maria da Cunha Galvão, Henrique Rocha de Medeiros, Antônia Cláudia Jácome da Câmara, Manuela Sales Lima Nascimento, Renata Antonaci Gama and Paulo Marcos Matta Guedes
    Citation: Parasites & Vectors 2021 14:456
    Content type: Research Published on:

  4. The study objective was to examine cat owner ectoparasiticide purchases in the United States and estimate the impact of purchase gaps on timely ectoparasite protection administration. These purchase gaps lead ...

    Authors: Robert Lavan, Dorothy Normile, Imran Husain, Amita Singh and Kathleen Heaney
    Citation: Parasites & Vectors 2021 14:264
    Content type: Research Published on:

  5. Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in the New World, where the sand fly Lutzomyia longipalpis and domestic dogs are considered the main vector and host reservoirs, respect...

    Authors: Tamyres Bernadete Dantas Queiroga, Henrique Rafael Pontes Ferreira, Wilo Victor dos Santos, Ana Beatriz Lourenço de Assis, Vicente Toscano de Araújo Neto, Antônia Cláudia Jácome da Câmara, João Ciro Fagundes Neto, Romeika Karla dos Reis, Manuela Sales Lima Nascimento, Renata Antonaci Gama and Paulo Marcos Matta Guedes
    Citation: Parasites & Vectors 2020 13:609
    Content type: Research Published on:

  6. Safe and effective flea and tick treatment options for cats are important in companion animal practice because of feline ectoparasite infestation prevalence and the potential for parasitic disease transmission...

    Authors: Robert Lavan, Rob Armstrong, Dorothy Normile and Wendy Vaala
    Citation: Parasites & Vectors 2020 13:541
    Content type: Short report Published on:

  7. Successful canine sarcoptic mange treatment requires immediate efficacy to eliminate active mites, and sustained activity to prevent re-infestation from in-contact animals and fomites. With extended acaricidal...

    Authors: Rafael Chiummo, Ivo Petersen, Claudia Plehn, Eva Zschiesche, Rainer Roepke and Emmanuel Thomas
    Citation: Parasites & Vectors 2020 13:524
    Content type: Research Published on:

  8. Recent reports indicate that the isoxazoline compounds have the potential to provide safe and effective treatment of canine generalized demodicosis, a condition that has been traditionally difficult to cure. C...

    Authors: Ivo Petersen, Rafael Chiummo, Eva Zschiesche, Joanna Karas-Tecza, Dhimiter Rapti, Rainer Roepke and Emmanuel Thomas
    Citation: Parasites & Vectors 2020 13:304
    Content type: Research Published on:

  9. A spot-on formulation of fluralaner plus moxidectin has been designed to provide long-term protection against fleas and ticks, prevent heartworm disease and treat gastrointestinal nematode infections in cats. ...

    Authors: Petr Fisara, Frank Guerino and Fangshi Sun
    Citation: Parasites & Vectors 2019 12:259
    Content type: Research Published on:

  10. Haemaphysalis longicornis ticks represent an ectoparasitic health threat to dogs. This study evaluated the immediate and persistent efficacy of orally administered fluralaner for control of this tick.

    Authors: Masanori Toyota, Kyoko Hirama, Tatsumi Suzuki, Rob Armstrong and Tatsuyuki Okinaga
    Citation: Parasites & Vectors 2019 12:43
    Content type: Short report Published on:

  11. A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) has been developed to provide broad spectrum parasite protection for cats. The effectiveness and safety of th...

    Authors: Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Thierry Pobel, Maria José Gil and Rainer K. A. Roepke
    Citation: Parasites & Vectors 2018 11:598
    Content type: Research Published on:

  12. Fluralaner provides efficacy against feline ectoparasites following topical administration. Moxidectin is routinely used to treat gastrointestinal nematode infections and prevent heartworm disease caused by Dirof...

    Authors: Feli M. Walther, Petr Fisara and Rainer K. A. Roepke
    Citation: Parasites & Vectors 2018 11:597
    Content type: Short report Published on:

  13. The efficacy of the fixed combination of fluralaner plus moxidectin for the treatment of Otodectes cynotis infestations was evaluated in cats after topical application.

    Authors: Janina Taenzler, Christa de Vos, Rainer K. A. Roepke and Anja R. Heckeroth
    Citation: Parasites & Vectors 2018 11:595
    Content type: Research Published on:

  14. A spot-on formulation containing fluralaner (280 mg/ml) plus moxidectin (14 mg/ml) (Bravecto® Plus) was developed for the treatment of nematode infections as well as providing 12 weeks of protection against in...

    Authors: Nadja Rohdich, Eva Zschiesche, Oliver Wolf, Wolfgang Loehlein, Zvezdelina Kirkova, Petar Iliev, Dhimitër Rapti, Rezart Postoli, Balázs Capári, Róbert Farkas and Rainer K. A. Roepke
    Citation: Parasites & Vectors 2018 11:589
    Content type: Research Published on:

  15. Veterinary clinic transaction records from the USA were examined to determine dog owner purchase patterns for three prescription ectoparasiticides. In-clinic purchases of formulations of fluralaner (with 12-we...

    Authors: Robert Lavan, Rob Armstrong, Kaan Tunceli and Dorothy Normile
    Citation: Parasites & Vectors 2018 11:581
    Content type: Short report Published on:

  16. Dipylidium caninum is a common tapeworm of dogs contracted from ingestion of fleas containing the infective cysticercoid stage. Fluralaner is a systemically distributed isoxazoline class insecticide that delivers...

    Authors: Deepa Gopinath, Leon Meyer, Jehane Smith and Rob Armstrong
    Citation: Parasites & Vectors 2018 11:557
    Content type: Research Published on:

  17. Heartworm medications and many oral or topical flea and tick products are provided as monthly doses while a newer oral flea/tick product, fluralaner (BRAVECTO® Chew), is re-dosed at a 12-week interval. This st...

    Authors: Robert Lavan, Kathleen Heaney, Srinivasan Rajagopalan Vaduvoor and Kaan Tunceli
    Citation: Parasites & Vectors 2018 11:493
    Content type: Short report Published on:

  19. An investigation was conducted in West Central Florida, USA to evaluate the efficacy of either topically applied fluralaner or topically applied selamectin to control flea infestations, minimize dermatologic l...

    Authors: Michael W. Dryden, Michael S. Canfield, Cara Bocon, Letitia Phan, Emily Niedfeldt, Amanda Kinnon, Stanislaw A. Warcholek, Vicki Smith, Todd S. Bress, Nicole Smith, Kathleen Heaney, Christine Royal, Dorothy Normile, Robert Armstrong and Fangshi Sun
    Citation: Parasites & Vectors 2018 11:422
    Content type: Research Published on:

  20. Fluralaner (Bravecto®, Merck Animal Health, Madison, NJ, USA) is a novel isoxazoline that provides up to 12 weeks flea and tick control when administered orally to dogs. Two assessor-blinded studies, one in do...

    Authors: Sivaja Ranjan, David Young and Fangshi Sun
    Citation: Parasites & Vectors 2018 11:385
    Content type: Research Published on:

  22. Fluralaner is a novel systemic ectoparasiticide for dogs and cats providing immediate and persistent flea- and tick-control after a single topical dose. Prescribing directions recommend waiting 72 h following ...

    Authors: Heide Dongus, Leon Meyer and Rob Armstrong
    Citation: Parasites & Vectors 2017 10:441
    Content type: Short report Published on:

  23. The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal ...

    Authors: Heike Kohler-Aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche and Anja R Heckeroth
    Citation: Parasites & Vectors 2017 10:426
    Content type: Research Published on:

  24. Adherence to a prescribed therapeutic regimen is a critical factor for achieving medication effectiveness and therefore treatment success. In the case of companion animal ectoparasite control, suboptimal owner...

    Authors: Robert P. Lavan, Kaan Tunceli, Dongmu Zhang, Dorothy Normile and Rob Armstrong
    Citation: Parasites & Vectors 2017 10:284
    Content type: Research Published on:

  26. Orally administered fluralaner effectively controls fleas and ticks on dogs for 12 weeks. This study evaluates the flea control efficacy achieved with topically applied fluralaner in dogs.

    Authors: Cheyney Meadows, Frank Guerino and Fangshi Sun
    Citation: Parasites & Vectors 2017 10:36
    Content type: Research Published on:

  28. Acaricides are used to treat and prevent tick infestations, and a common clinical scenario is to administer an acaricide on observing an attached tick. Consequently, immediate acaricidal efficacy (onset of act...

    Authors: Federica Burgio, Leon Meyer and Rob Armstrong
    Citation: Parasites & Vectors 2016 9:626
    Content type: Research Published on:

  30. The efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. canis infestation in dogs.

    Authors: Janina Taenzler, Julian Liebenberg, Rainer K. A. Roepke, Régis Frénais and Anja R. Heckeroth
    Citation: Parasites & Vectors 2016 9:392
    Content type: Research Published on:

  31. A study was conducted to evaluate and compare the effectiveness of two different oral flea and tick products to control flea infestations, reduce pruritus and minimize dermatologic lesions over a 12 week perio...

    Authors: Michael W. Dryden, Michael S. Canfield, Kimberly Kalosy, Amber Smith, Lisa Crevoiserat, Jennifer C. McGrady, Kaitlin M. Foley, Kathryn Green, Chantelle Tebaldi, Vicki Smith, Tashina Bennett, Kathleen Heaney, Lisa Math, Christine Royal and Fangshi Sun
    Citation: Parasites & Vectors 2016 9:365
    Content type: Research Published on:

  32. Fluralaner is a novel systemic ectoparasiticide for cats providing immediate and persistent flea- and tick-control after a single topical dose. Emodepsid and praziquantel are routinely used to control intestin...

    Authors: Feli M. Walther, Mark J. Allan and Rainer K. A. Roepke
    Citation: Parasites & Vectors 2016 9:322
    Content type: Short report Published on:

    The Erratum to this article has been published in Parasites & Vectors 2016 9:366

  33. Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral...

    Authors: Susanne Kilp, Diana Ramirez, Mark J Allan and Rainer KA Roepke
    Citation: Parasites & Vectors 2016 9:296
    Content type: Research Published on:

  34. The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period.

    Authors: Janina Taenzler, Julian Liebenberg, Machiel Mienie, William R. Everett, David R. Young, Thomas S. Vihtelic, Fangshi Sun, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth
    Citation: Parasites & Vectors 2016 9:276
    Content type: Research Published on:

  36. Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. The active ingredient fluralaner is dis...

    Authors: Janina Taenzler, Boyd Gale, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth
    Citation: Parasites & Vectors 2016 9:233
    Content type: Research Published on:

  37. Fluralaner is the first orally administered isoxazoline to provide 12 weeks of activity against fleas and ticks after a single administration. As a result of its potent anti-flea activity, oral fluralaner may ...

    Authors: Odile Crosaz, Elodie Chapelle, Noëlle Cochet-Faivre, Diane Ka, Céline Hubinois and Jacques Guillot
    Citation: Parasites & Vectors 2016 9:174
    Content type: Research Published on:

  38. Fluralaner is a novel systemic ectoparasiticide for dogs providing immediate and persistent flea, tick and mite control after a single oral dose. Ivermectin has been used in dogs for heartworm prevention and a...

    Authors: Feli M. Walther, Mark J. Allan and Rainer KA Roepke
    Citation: Parasites & Vectors 2015 8:508
    Content type: Short Report Published on:

  39. Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against ...

    Authors: Michael W Dryden, Vicki Smith, Tashina Bennett, Lisa Math, James Kallman, Kathleen Heaney and Fangshi Sun
    Citation: Parasites & Vectors 2015 8:364
    Content type: Research Published on:

    The Erratum to this article has been published in Parasites & Vectors 2015 8:405

  40. Fluralaner is a new antiparasitic drug that was recently introduced as BravectoTM chewable tablets for the treatment of tick and flea infestations in dogs. Most marketed tick products exert their effect via topic...

    Authors: Heike Williams, Janina Demeler, Janina Taenzler, Rainer K.A. Roepke, Eva Zschiesche and Anja R. Heckeroth
    Citation: Parasites & Vectors 2015 8:352
    Content type: Research Published on:

  41. The preventive effect of fluralaner chewable tablets (Bravecto™) against transmission of Babesia canis by Dermacentor reticulatus ticks was evaluated.

    Authors: Janina Taenzler, Julian Liebenberg, Rainer K.A. Roepke and Anja R. Heckeroth
    Citation: Parasites & Vectors 2015 8:305
    Content type: Research Published on:

  42. Ixodes holocyclus ticks are a frequently fatal threat to dogs in eastern Australia. These ticks secrete a neurotoxin that can produce an ascending paralysis after 72 h attachment that can lead ...

    Authors: Petr Fisara and Maurice Webster
    Citation: Parasites & Vectors 2015 8:257
    Content type: Research Published on:

  43. This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against ...

    Authors: Josephus J Fourie, Julian E Liebenberg, Ivan G Horak, Janina Taenzler, Anja R Heckeroth and Regis Frénais
    Citation: Parasites & Vectors 2015 8:187
    Content type: Research Published on:

  44. Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the suscept...

    Authors: Heike Williams, Hartmut Zoller, Rainer KA Roepke, Eva Zschiesche and Anja R Heckeroth
    Citation: Parasites & Vectors 2015 8:90
    Content type: Research Published on:

  45. Fluralaner (Bravecto™) is a novel systemic insecticide and acaricide that provides long persistent antiparasitic activity following a single administration at the minimum dose of 25 mg/kg body weight.

    Authors: Janina Taenzler, Christina Wengenmayer, Heike Williams, Josephus Fourie, Eva Zschiesche, Rainer KA Roepke and Anja R Heckeroth
    Citation: Parasites & Vectors 2014 7:567
    Content type: Research Published on:

  46. Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to preven...

    Authors: Christina Wengenmayer, Heike Williams, Eva Zschiesche, Andreas Moritz, Judith Langenstein, Rainer KA Roepke and Anja R Heckeroth
    Citation: Parasites & Vectors 2014 7:525
    Content type: Research Published on:

  47. Fluralaner (Bravecto™; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routine...

    Authors: Feli M Walther, Petr Fisara, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger
    Citation: Parasites & Vectors 2014 7:481
    Content type: Short report Published on:

  49. Fluralaner, a novel isoxazoline, has both acaricidal and insecticidal activity through potent blockage of GABA- and L-glutamate-gated chloride channels. This study investigated the in vitro and in vivo effects of...

    Authors: Heike Williams, David R Young, Tariq Qureshi, Hartmut Zoller and Anja R Heckeroth
    Citation: Parasites & Vectors 2014 7:275
    Content type: Research Published on:

  50. Bravecto™ (fluralaner; MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Scalibor™ Protectorband (deltamethrin; MSD Animal ...

    Authors: Feli M Walther, Petr Fisara, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger
    Citation: Parasites & Vectors 2014 7:105
    Content type: Short report Published on: