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Bravecto TM

This article collection page focusing on Bravecto™ (fluranaler) was created to facilitate access to articles published in Parasites & Vectors relating to this topic. The article processing charges for the articles in the collection have been funded by MSD Animal Health and a detailed conflict of interest statement is included within each article. The articles in this collection have undergone the journal’s standard peer-review process and each article can also be found individually in the journal.

Non-English translations of some articles in this collection can be viewed here

Collection published: 6 March 2014

View all collections published in Parasites & Vectors


  1. Content type: Short report

    Fluralaner is a novel systemic ectoparasiticide for dogs and cats providing immediate and persistent flea- and tick-control after a single topical dose. Prescribing directions recommend waiting 72 h following ...

    Authors: Heide Dongus, Leon Meyer and Rob Armstrong

    Citation: Parasites & Vectors 2017 10:441

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  2. Content type: Research

    The clinical efficacy of fluralaner chewable tablets (Bravecto™, MSD Animal Health) against naturally acquired Linognathus setosus infestations on dogs was evaluated compared with permethrin (Exspot®, MSD Animal ...

    Authors: Heike Kohler-Aanesen, Seppo Saari, Rob Armstrong, Karine Péré, Janina Taenzler, Eva Zschiesche and Anja R Heckeroth

    Citation: Parasites & Vectors 2017 10:426

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  3. Content type: Research

    Adherence to a prescribed therapeutic regimen is a critical factor for achieving medication effectiveness and therefore treatment success. In the case of companion animal ectoparasite control, suboptimal owner...

    Authors: Robert P. Lavan, Kaan Tunceli, Dongmu Zhang, Dorothy Normile and Rob Armstrong

    Citation: Parasites & Vectors 2017 10:284

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  4. Content type: Research

    Orally administered fluralaner effectively controls fleas and ticks on dogs for 12 weeks. This study evaluates the flea control efficacy achieved with topically applied fluralaner in dogs.

    Authors: Cheyney Meadows, Frank Guerino and Fangshi Sun

    Citation: Parasites & Vectors 2017 10:36

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  5. Content type: Research

    Acaricides are used to treat and prevent tick infestations, and a common clinical scenario is to administer an acaricide on observing an attached tick. Consequently, immediate acaricidal efficacy (onset of act...

    Authors: Federica Burgio, Leon Meyer and Rob Armstrong

    Citation: Parasites & Vectors 2016 9:626

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  6. Content type: Research

    The efficacy of fluralaner, formulated as a chewable tablet (Bravecto™) or topical solution (Bravecto™ Spot-on Solution), was evaluated against naturally acquired Sarcoptes scabiei var. canis infestation in dogs.

    Authors: Janina Taenzler, Julian Liebenberg, Rainer K. A. Roepke, Régis Frénais and Anja R. Heckeroth

    Citation: Parasites & Vectors 2016 9:392

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  7. Content type: Research

    A study was conducted to evaluate and compare the effectiveness of two different oral flea and tick products to control flea infestations, reduce pruritus and minimize dermatologic lesions over a 12 week perio...

    Authors: Michael W. Dryden, Michael S. Canfield, Kimberly Kalosy, Amber Smith, Lisa Crevoiserat, Jennifer C. McGrady, Kaitlin M. Foley, Kathryn Green, Chantelle Tebaldi, Vicki Smith, Tashina Bennett, Kathleen Heaney, Lisa Math, Christine Royal and Fangshi Sun

    Citation: Parasites & Vectors 2016 9:365

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  8. Content type: Short report

    Fluralaner is a novel systemic ectoparasiticide for cats providing immediate and persistent flea- and tick-control after a single topical dose. Emodepsid and praziquantel are routinely used to control intestin...

    Authors: Feli M. Walther, Mark J. Allan and Rainer K. A. Roepke

    Citation: Parasites & Vectors 2016 9:322

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    The Erratum to this article has been published in Parasites & Vectors 2016 9:366

  9. Content type: Research

    The efficacy of fluralaner spot-on solution administered once topically against induced infestations with Rhipicephalus sanguineus was evaluated in dogs over a 12-week post-treatment period.

    Authors: Janina Taenzler, Julian Liebenberg, Machiel Mienie, William R. Everett, David R. Young, Thomas S. Vihtelic, Fangshi Sun, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth

    Citation: Parasites & Vectors 2016 9:276

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  10. Content type: Research

    Bravecto™ Chewable Tablets for Dogs, containing fluralaner as active ingredient, is an innovative treatment for flea and tick infestations that provides safe, rapid and long acting efficacy after a single oral...

    Authors: Susanne Kilp, Diana Ramirez, Mark J Allan and Rainer KA Roepke

    Citation: Parasites & Vectors 2016 9:296

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  11. Content type: Research

    Fluralaner spot-on solution provides immediate and persistent efficacy against tick and flea infestations in dogs and cats for 12-weeks following topical administration. The active ingredient fluralaner is dis...

    Authors: Janina Taenzler, Boyd Gale, Eva Zschiesche, Rainer K. A. Roepke and Anja R. Heckeroth

    Citation: Parasites & Vectors 2016 9:233

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  12. Content type: Research

    Fluralaner is the first orally administered isoxazoline to provide 12 weeks of activity against fleas and ticks after a single administration. As a result of its potent anti-flea activity, oral fluralaner may ...

    Authors: Odile Crosaz, Elodie Chapelle, Noëlle Cochet-Faivre, Diane Ka, Céline Hubinois and Jacques Guillot

    Citation: Parasites & Vectors 2016 9:174

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  13. Content type: Short Report

    Fluralaner is a novel systemic ectoparasiticide for dogs providing immediate and persistent flea, tick and mite control after a single oral dose. Ivermectin has been used in dogs for heartworm prevention and a...

    Authors: Feli M. Walther, Mark J. Allan and Rainer KA Roepke

    Citation: Parasites & Vectors 2015 8:508

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  14. Content type: Research

    Fluralaner is a potent insecticide and acaricide with rapid and persistent efficacy. This study measured the efficacy of fluralaner flavored chews (Bravecto®, Merck Animal Health) administered to dogs against ...

    Authors: Michael W Dryden, Vicki Smith, Tashina Bennett, Lisa Math, James Kallman, Kathleen Heaney and Fangshi Sun

    Citation: Parasites & Vectors 2015 8:364

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    The Erratum to this article has been published in Parasites & Vectors 2015 8:405

  15. Content type: Research

    Fluralaner is a new antiparasitic drug that was recently introduced as BravectoTM chewable tablets for the treatment of tick and flea infestations in dogs. Most marketed tick products exert their effect via topic...

    Authors: Heike Williams, Janina Demeler, Janina Taenzler, Rainer K.A. Roepke, Eva Zschiesche and Anja R. Heckeroth

    Citation: Parasites & Vectors 2015 8:352

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  16. Content type: Research

    The preventive effect of fluralaner chewable tablets (Bravecto™) against transmission of Babesia canis by Dermacentor reticulatus ticks was evaluated.

    Authors: Janina Taenzler, Julian Liebenberg, Rainer K.A. Roepke and Anja R. Heckeroth

    Citation: Parasites & Vectors 2015 8:305

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  17. Content type: Research

    Ixodes holocyclus ticks are a frequently fatal threat to dogs in eastern Australia. These ticks secrete a neurotoxin that can produce an ascending paralysis after 72 h attachment that can lead ...

    Authors: Petr Fisara and Maurice Webster

    Citation: Parasites & Vectors 2015 8:257

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  18. Content type: Research

    This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against ...

    Authors: Josephus J Fourie, Julian E Liebenberg, Ivan G Horak, Janina Taenzler, Anja R Heckeroth and Regis Frénais

    Citation: Parasites & Vectors 2015 8:187

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  19. Content type: Research

    Fluralaner is a novel isoxazoline eliciting both acaricidal and insecticidal activity through potent blockage of GABA- and glutamate-gated chloride channels. The aim of the study was to investigate the suscept...

    Authors: Heike Williams, Hartmut Zoller, Rainer KA Roepke, Eva Zschiesche and Anja R Heckeroth

    Citation: Parasites & Vectors 2015 8:90

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  20. Content type: Research

    Fluralaner (Bravecto™) is a novel systemic insecticide and acaricide that provides long persistent antiparasitic activity following a single administration at the minimum dose of 25 mg/kg body weight.

    Authors: Janina Taenzler, Christina Wengenmayer, Heike Williams, Josephus Fourie, Eva Zschiesche, Rainer KA Roepke and Anja R Heckeroth

    Citation: Parasites & Vectors 2014 7:567

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  21. Content type: Research

    Pathogens that are transmitted by ticks to dogs, such as Anaplasma phagocytophilum, Babesia spp., Borrelia burgdorferi sensu latu, and Ehrlichia canis, are an increasing problem in the world. One method to preven...

    Authors: Christina Wengenmayer, Heike Williams, Eva Zschiesche, Andreas Moritz, Judith Langenstein, Rainer KA Roepke and Anja R Heckeroth

    Citation: Parasites & Vectors 2014 7:525

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  22. Content type: Short report

    Fluralaner (Bravecto™; Merck/MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea and tick control after a single oral dose. Milbemycin oxime and praziquantel are routine...

    Authors: Feli M Walther, Petr Fisara, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:481

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  23. Content type: Research

    Fluralaner, a novel isoxazoline, has both acaricidal and insecticidal activity through potent blockage of GABA- and L-glutamate-gated chloride channels. This study investigated the in vitro and in vivo effects of...

    Authors: Heike Williams, David R Young, Tariq Qureshi, Hartmut Zoller and Anja R Heckeroth

    Citation: Parasites & Vectors 2014 7:275

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  24. Content type: Short report

    Bravecto™ (fluralaner; MSD Animal Health) is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. Scalibor™ Protectorband (deltamethrin; MSD Animal ...

    Authors: Feli M Walther, Petr Fisara, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:105

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  25. Content type: Research

    Fluralaner is a novel systemic insecticide and acaricide that provides long acting efficacy in dogs after a single oral treatment. This study investigated the safety of oral administration of fluralaner in che...

    Authors: Feli M Walther, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:87

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  26. Content type: Research

    Fluralaner is a novel systemic insecticide and acaricide. The purpose of these studies was to investigate the pharmacokinetic properties of fluralaner in Beagle dogs following single oral or intravenous (i.v.)...

    Authors: Susanne Kilp, Diana Ramirez, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:85

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  27. Content type: Research

    Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. This study investigated the safety of oral administration of fluralaner at 3 time...

    Authors: Feli M Walther, Allan J Paul, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:86

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  28. Content type: Research

    Fluralaner is a novel systemic ectoparasiticide for dogs providing long-acting flea- and tick-control after a single oral dose. The pharmacokinetics of orally administered drugs may be influenced by feeding. T...

    Authors: Feli M Walther, Mark J Allan, Rainer KA Roepke and Martin C Nuernberger

    Citation: Parasites & Vectors 2014 7:84

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  29. Content type: Research

    Fluralaner, a new molecular entity of the isoxazoline class, has potent insecticidal and acaricidal activity and can be safely administered orally to dogs.

    Authors: Nadja Rohdich, Rainer KA Roepke and Eva Zschiesche

    Citation: Parasites & Vectors 2014 7:83

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