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Biomarkers of neurological diseases

Guest Editors:
Santiago Perez-Lloret: Pontifical Catholic University of Argentina, National Research Council of Argentina
Wen-Jun Tu: Chinese Academy of Medical Sciences & Peking Union Medical College, China

BMC Neurology announced a new Collection focused on biomarkers of neurological diseases.

This Collection aims to explore how research into associated biomarkers can contribute to our understanding, diagnosis, and management of neurological conditions that affect millions of people worldwide.

SDG logo smallThis collection supports and amplifies research related to SDG 3: Good Health & Well-Being.

Meet the Guest Editors

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Santiago Perez-Lloret: Pontifical Catholic University of Argentina, National Research Council of Argentina

Santiago Perez-Lloret is a leading expert in neurophysiology and neuropharmacology, with more than 130 papers published in international medical journals. After obtaining his MD and PhD at the University of Buenos Aires, he pursued master’s courses in pharmacoepidemiology, clinical pharmacology, and biostatistics at the Universities of Toulouse, Bordeaux, and Paris. Dr Perez-Lloret is an Assistant Professor of Neurophysiology at the Medicine School of the University of Buenos Aires and a Senior Researcher at the Catholic University of Argentina, National Research Council. He is also an Associate Editor of BMC Neurology and a member of the Evidence-Based Medicine Committee of the International Parkinson’s Disease and Movement Disorder Society (MDS).
 

Wen-Jun Tu: Chinese Academy of Medical Sciences & Peking Union Medical College, China

Dr Wen-Jun Tu mainly engages in the following fields: prevention, diagnosis, prognosis, and rehabilitation of cerebrovascular diseases; development of biological kits; and construction of cerebrovascular disease biobanks. The future of his work is mainly focused on clinical applications of brain-computer interfaces. He has published more than 50 recent SCI-indexed papers with over 2,000 citations. He is an Associate Editor of several medical titles, including BMC Neurology.

About the collection

BMC Neurology is now welcoming submissions to a new Collection on biomarkers of neurological diseases and their potential in understanding, diagnosing, and managing various neurological conditions that impact millions of lives worldwide.

Neurological diseases, such as stroke, Parkinson’s disease, and multiple sclerosis pose significant challenges to individuals, their families, and healthcare systems. These conditions remain a significant public health concern, and as such, effective diagnostic tools, prognostic indicators, and personalized treatment strategies are in high demand. Measurable molecules and substances known as biomarkers hold immense promise in fulfilling these needs.

In this Collection, we invite submissions of cutting-edge original research offering novel perspectives on the identification, validation, and utilization of biomarkers in neurological diseases. We seek contributions that span a broad spectrum of disciplines, including genomics, proteomics, epidemiology, metabolomics, and transcriptomics. By embracing the synergistic power of these fields, we can harness the potential of biomarkers and grow closer to implementing them in clinical contexts.

Topics of interest to this Collection include, but are not limited to:

  •  Novel biomarkers for early detection and diagnosis of stroke, Parkinson’s disease, multiple sclerosis, or other neurological diseases
  •  Advancements in MRI, PET, or CT-based imaging biomarkers for neurologic disease detection and monitoring
  •  Using inflammatory markers as predictors of neurological disease progression and severity
  •  Oxidative stress as an indicator of neurodegeneration and potential targets for treatment response
  •  Using neurofilament proteins, tau protein, alpha-synuclein, and myelin-specific markers to diagnose the neuronal damage, degeneration, and myelin integrity associated with various neurological diseases
  •  The role of non-invasive biomarkers in neurology, such as blood-based or cerebrospinal fluid (CSF) biomarkers
  •  Challenges and opportunities in translating biomarker research to clinical practice


Image credit: Shidlovski / Getty Images / iStock

  1. Base excess (BE) is associated with mortality from many diseases. However, the relationship between BE and mortality in patients with ischemic stroke remains uncertain. Our aim is to investigate the relationsh...

    Authors: Jueheng Liu, Jiamei Li, Xuting Jin, Jiajia Ren, Ruohan Li, Jingjing Zhang, Ya Gao, Xiaochuang Wang and Gang Wang
    Citation: BMC Neurology 2024 24:351
    Content type: Research Published on:

  2. Associations between HbA1c and adverse outcomes in ischemic and hemorrhagic stroke have been confirmed. It is still unclear whether HbA1c is related to the activities of daily living (ADL) score in complex chr...

    Authors: Ying Zheng, Chenju Zhan, Qixi Liu and Chengsheng Chen
    Citation: BMC Neurology 2024 24:342
    Content type: Research Published on:

  4. Neurolymphomatosis (NL) is a rare neurologic manifestation of non-Hodgkin lymphoma (NHL) with poor prognosis. Investigations including MRI, PET/CT, nerve biopsy and cerebrospinal fluid (CSF) analysis can aid t...

    Authors: Honglian Zhang, Si Chen, Jing Li, Huan Yang and Yue-Bei Luo
    Citation: BMC Neurology 2024 24:320
    Content type: Case Report Published on:

  5. The objective of this study was to establish a predictive model utilizing machine learning techniques to anticipate the likelihood of thrombolysis resistance (TR) in acute ischaemic stroke (AIS) patients under...

    Authors: Xiaorui Wang, Song Luo, Xue Cui, Hongdang Qu, Yujie Zhao and Qirong Liao
    Citation: BMC Neurology 2024 24:296
    Content type: Research Published on:

  7. Glycated albumin (GA) is an indicator of glycemic variability over the past 2–4 weeks and has suitable characteristics for predicting the prognosis of ischemic stroke during the acute phase. This study evaluat...

    Authors: Ki-Woong Nam, Jung Hoon Han, Chi Kyung Kim, Hyung-Min Kwon, Yong-Seok Lee, Kyungmi Oh, Keon-Joo Lee and Byeongsu Park
    Citation: BMC Neurology 2024 24:278
    Content type: Research Published on:

  8. Prior research had indicated a relationship between fibrinogen and stroke-associated pneumonia (SAP), yet the nature of this relationship had not been thoroughly investigated. Therefore, this study was designe...

    Authors: Xiaoqiang Li, Hui Du, Zhibin Song, Meiqi, Guifeng Zhang, Suhua Yuan, Yuanfeng and Hui Wang
    Citation: BMC Neurology 2024 24:256
    Content type: Research Published on:

  9. Neurofilament Light (NfL) is a biomarker for early neurodegeneration in Alzheimer’s disease (AD). This study aims to examine the association between plasma NfL and multi-modal neuroimaging features across the ...

    Authors: Qili Hu, Mengqiu Shi, Yunfei Li and Xiaohu Zhao
    Citation: BMC Neurology 2024 24:236
    Content type: Research Published on:

  10. Diagnosis and monitoring of leptomeningeal malignancy remain challenging, and are usually based on neurological, radiological, cerebrospinal fluid (CSF) and pathological findings. This study aimed to investiga...

    Authors: Le Zhang, Kechi Fang, Haitao Ren, Siyuan Fan, Jing Wang and Hongzhi Guan
    Citation: BMC Neurology 2024 24:223
    Content type: Research Published on:

  11. Growing evidence indicated that to develop of atherosclerosis observed more often by people with Alzheimer’s disease (AD), but the underlying mechanism is not fully clarified. Considering that amyloid-β (Aβ) d...

    Authors: Chen Chen, Wang Anqi, Gao Ling, Wei Shan, Dang Liangjun, Shang Suhang, Huo Kang, Gao Fan, Wang Jingyi, Qu Qiumin and Wang Jin
    Citation: BMC Neurology 2024 24:218
    Content type: Research Published on:

  12. Parkinson’s disease (PD) significantly impacts the health-related quality of life of affected individuals and their relatives. In order to support the affected individuals and their families in coping with PD,...

    Authors: Theresia Krieger, Leonie Jozwiak, Georg Ebersbach, Thorsten Suess, Björn Falkenburger, Tim Feige, Carsten Eggers, Tobias Warnecke, Winfried Scholl, Christian Schmidt-Heisch, Ann-Kristin Folkerts, Elke Kalbe and Ümran Sema Seven
    Citation: BMC Neurology 2024 24:208
    Content type: Research Published on:

  13. Hypoxia can cause a variety of diseases, including ischemic stroke and neurodegenerative diseases. Within a certain range of partial pressure of oxygen, cells can respond to changes in oxygen. Changes in oxyge...

    Authors: Chuncheng Liu, Gehui Liu, Xinyang Zuo, Donghui Qu, Yefeng Sun, Linan Liu, Xiujuan Zhao, Jun Li and Lu Cai
    Citation: BMC Neurology 2024 24:204
    Content type: Research Published on:

  14. Individuals with spinal cord injury (SCI) can experience accelerated cognitive aging. Myokines (factors released from muscle cells during contractions), such as brain-derived neurotrophic factor (BDNF), are th...

    Authors: Wouter A. J. Vints, Oron Levin, Martijn van Griensven, Johan W. S. Vlaeyen, Nerijus Masiulis, Jeanine Verbunt and Charlotte C. M. van Laake-Geelen
    Citation: BMC Neurology 2024 24:197
    Content type: Study Protocol Published on:

  15. The newest generation of Neuroform Atlas stentâ„¢ (Stryker, Fremont, California) represents a recent advance of cerebral laser-cut microstents for the treatment of intracranial wide-necked aneurysms, and postope...

    Authors: Shibao Chen, Huibin Kang, Dili Wang, Yan Li, Jamali Aikebaier, Yabo Li, Xinshan Wu, Yuhua Guan and Yisen Zhang
    Citation: BMC Neurology 2024 24:195
    Content type: Research Published on:

  16. Serum uric acid (UA) and the neutrophil-to-lymphocyte ratio (NLR) have been reported to be associated with outcomes in acute ischemic stroke (AIS). However, whether UA is related to the prognosis of AIS patien...

    Authors: Chentao Wang, Meili Zhou, Tingting Kang, Shoujiang You, Yongjun Cao, Weina Kong and Jijun Shi
    Citation: BMC Neurology 2024 24:183
    Content type: Research Published on:

  17. Acute ischemic stroke (AIS) is one of the most common cerebrovascular diseases which accompanied by a disruption of aminothiols homeostasis. To explore the relationship of aminothiols with neurologic impairmen...

    Authors: Wei-Chong Dong, Jia-Liang Guo, Lei Xu, Xin-Hui Jiang, Cheng-Hao Chang, Ye Jiang and Ying-Ze Zhang
    Citation: BMC Neurology 2024 24:175
    Content type: Research Published on:

  18. The thalamus has a central role in the pathophysiology of idiopathic cervical dystonia (iCD); however, the nature of alterations occurring within this structure remain largely elusive. Using a structural magne...

    Authors: Yuhan Luo, Huiming Liu, Linchang Zhong, Ai Weng, Zhengkun Yang, Yue Zhang, Jiana Zhang, Xiuye He, Zilin Ou, Zhicong Yan, Qinxiu Cheng, Xinxin Fan, Xiaodong Zhang, Weixi Zhang, Qingmao Hu, Kangqiang Peng…
    Citation: BMC Neurology 2024 24:174
    Content type: Research Published on:

  20. Atherosclerosis are well established risk factors for ischemic stroke, however the association between alcohol consumption and atherosclerosis is controversial. This study aims to explore the potential correla...

    Authors: Yiti Liu, Shuo Gu, Maoyuan Gou and Xiaoyan Guo
    Citation: BMC Neurology 2024 24:135
    Content type: Research Published on:

  21. Serum CGRP has been found to increase during migraine attack. However, whether CGRP can identify MA with PFO subtypes in MA remains unknown. This study aimed to investigate the differential expression of calci...

    Authors: Chaojie Li, Yu Yu, Ningning Li, Ya-Na Yin, Lianjun Zhang, Kehang Xie and Donghui Huang
    Citation: BMC Neurology 2024 24:126
    Content type: Research Published on:

  22. Complex interactions between the immune system and the brain may affect neural development, survival, and function, with etiological and therapeutic implications for neurodegenerative diseases. However, previo...

    Authors: Min Shen, Linlin Zhang, Chen Chen, Xiaocen Wei, Yuning Ma and Yuxia Ma
    Citation: BMC Neurology 2024 24:98
    Content type: Research Published on:

  24. Human prion diseases (HPDs) are fatal neurodegenerative disorders characterized by abnormal prion proteins (PrPSc). However, the detection of prion seeding activity in patients with high sensitivity remains ch...

    Authors: Toshiaki Nonaka, Yasushi Iwasaki, Hiroyuki Horiuchi and Katsuya Satoh
    Citation: BMC Neurology 2024 24:92
    Content type: Research Published on:

  25. The global prevalence of VCI has increased steadily in recent years, but diagnostic biomarkers for VCI in patients with non-disabling ischemic cerebrovascular incidents (NICE) remain indefinite. The primary ob...

    Authors: Binghan Li, Zhengsheng Gu, Weisen Wang, Bingying Du, Chenghao Wu, Bin Li, Tianren Wang, Ge Yin, Xin Gao, Jingjing Chen, Xiaoying Bi, Hailing Zhang and Xu Sun
    Citation: BMC Neurology 2024 24:86
    Content type: Research Published on:

  27. CADASIL(Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy)is an inherited small vessel disease caused by mutations in NOTCH3 gene. Although NOTCH3 has numerous hotspots...

    Authors: Weili Liu, Jie Zhang, Jian Li, Shuai Jia, Yanqiang Wang, Jianhong Geng and Yaozhen Wang
    Citation: BMC Neurology 2024 24:77
    Content type: Case Report Published on:

  30. Little is known regarding the leading risk factors for dementia/Alzheimer’s disease (AD) in individuals with and without APOE4. The identification of key risk factors for dementia/Alzheimer’s disease (AD) in i...

    Authors: Siting Ye, Eddy Roccati, Wei Wang, Zhuoting Zhu, Katerina Kiburg, Yu Huang, Xueli Zhang, Xiayin Zhang, Jiahao Liu, Shulin Tang, Yijun Hu, Zongyuan Ge, Honghua Yu, Mingguang He and Xianwen Shang
    Citation: BMC Neurology 2024 24:71
    Content type: Research Published on:

  31. Identification of the causes of stroke of undetermined etiology, specifically cardioembolism (CE) and non-CE causes, can inform treatment planning and prognosis prediction. The objective of this study was to a...

    Authors: Yi Jiang, Zhichao Sun, Zhonglin Ge, Zhonghai Tao, Mengqian Liu, Wen Zhong, Nan Dong, Lei Xu, Hui Wang, Yiwen Xu and Xiaozhu Shen
    Citation: BMC Neurology 2024 24:70
    Content type: Research Published on:

  32. Objective assessment of post-COVID-19 cognitive dysfunction is highly warranted. This study aimed to evaluate the cognitive dysfunction of COVID-19 survivors with cognitive complaints, both clinically and neur...

    Authors: Manal M. Gaber, Hanan Hosny, Mona Hussein, Mona A. Ashmawy and Rehab Magdy
    Citation: BMC Neurology 2024 24:60
    Content type: Research Published on:

  33. Status epilepticus (SE) is a severe acute condition in neurocritical care with high mortality. Searching for risk factors affecting the prognosis in SE remains a significant issue. The primary study’s aim was ...

    Authors: Zdenek Krejzar, David Sila, Petr Waldauf, Eduard Kuriscak, Petr Mokrejs and Vera Spatenkova
    Citation: BMC Neurology 2024 24:46
    Content type: Research Published on:

  34. There is often a fear of social stigma experienced by people with multiple sclerosis (pwMS), which negatively impacts the quality of their lives (QoL). Currently, no Persian-validated questionnaire is availabl...

    Authors: Mohammad Amin Habibi, Mohammad Yazdan Panah, Saeed Vaheb, Meysam Olfatifar, Aysa Shaygannejad, Yousef Mokary, Majid Ghasemi, Sangharsha Thapa, Vahid Shaygannejad and Omid Mirmosayyeb
    Citation: BMC Neurology 2024 24:36
    Content type: Research Published on:

  35. Myasthenia gravis (MG) is an autoimmune disease that affects neuromuscular junction. The literature suggests the involvement of circulating cytokines (CK), gut microbiota (GM), and serum metabolites (SM) with ...

    Authors: Wenwen Wang, Wei Ge, Junling Feng, Manli Huang, Xihua Zhang, Jielai Xia, Ling Wang and Chen Li
    Citation: BMC Neurology 2024 24:33
    Content type: Research Published on:

  36. Inflammation is a major pathological mechanism underlying cerebrovascular disease. Recently, a new inflammatory marker based on the ratio between monocyte count and high-density lipoprotein (HDL) cholesterol h...

    Authors: Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park and Kyungha Min
    Citation: BMC Neurology 2024 24:18
    Content type: Research Published on:

  37. Stress hyperglycemia is a relatively transient increase in blood glucose in response to inflammation of the body and neurohormonal disorders. It is still debated whether stress hyperglycemia ratio (SHR) in the...

    Authors: Zhuoya Jiang, Kunyu Wang, Hanying Duan, Heqian Du, Su Gao, Jing Chen and Shaokuan Fang
    Citation: BMC Neurology 2024 24:13
    Content type: Research Published on:

  38. Thrombosis of dural sinuses and/or cerebral veins (CVT) is an uncommon form of cerebrovascular disease. Malnutrition is common in patients with cerebrovascular disease, and early assessment of malnutrition and...

    Authors: Weiwei Xiang, Yangyang Liang, Zhibo Chen, Hanmin Wang, Yangtai Guan and Dewei Xie
    Citation: BMC Neurology 2023 23:449
    Content type: Research Published on:

  40. Multiple inflammatory biomarkers have been shown to predict symptomatic cerebral vasospasm (SCVS) and poor functional outcome in patients with aneurysmal subarachnoid hemorrhage. However, the impact of the low...

    Authors: Ling wang, Ling Chen, Yang Jin, Xiangyang Cao, Liujun Xue and Qiantao Cheng
    Citation: BMC Neurology 2023 23:436
    Content type: Research Published on:

  41. Trimethylamine-N-oxide (TMAO), an intestinal microbiota-derived choline metabolite, has been found to be associated with ischemic stroke (IS) in more and more studies. However, the causal role of TMAO on IS oc...

    Authors: Xinhua Hu, Haiyan Ren and Yuan Cao
    Citation: BMC Neurology 2023 23:413
    Content type: Research Published on:

  42. A Phase I study showed that it is feasible to implement a home-based self-management program aimed at increasing physical activity in individuals after stroke with mild walking disability in Brazil. The next s...

    Authors: Maria Tereza Mota Alvarenga, Louise Ada, Elisabeth Preston, Lívia Cristina Guimarães Caetano, Luci Fuscaldi Teixeira-Salmela and Aline A Scianni
    Citation: BMC Neurology 2023 23:412
    Content type: Study Protocol Published on:

Submission Guidelines

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This Collection welcomes submission of original Research Articles. Should you wish to submit a different article type, please read our submission guidelines to confirm that type is accepted by the journal. Articles for this Collection should be submitted via our submission system, Snapp. During the submission process you will be asked whether you are submitting to a Collection, please select "Biomarkers of neurological diseases" from the dropdown menu.

Articles will undergo the journal’s standard peer-review process and are subject to all of the journal’s standard policies. Articles will be added to the Collection as they are published.

The Guest Editors have no competing interests with the submissions which they handle through the peer review process. The peer review of any submissions for which the Guest Editors have competing interests is handled by another Editorial Board Member who has no competing interests.