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Biomedical Engineering Online - 20th anniversary collection

New Content Item2022 marks an exciting milestone for Biomedical Engineering Online. We celebrate 20 years of publishing research and timely reviews in all areas of biomedical engineering, since our launch as a fully open access journal with BMC in 2002. With all research being made freely available online immediately after publication, and with a thorough and constructive review process, the journal has created a truly global community of biomedical engineers. In this 20th anniversary collection, we present a selection of highly cited publications that illustrate the broad scope and demonstrate the lasting impact of the journal on developments in the field.


  1. Osteosarcoma (OS) is the most common primary bone malignancy that affects children and young adults. OS is characterized by a high degree of malignancy, strong invasiveness, rapid disease progression, and extr...

    Authors: Xin Zhao, Qirui Wu, Xiuqing Gong, Jinfeng Liu and Yujie Ma
    Citation: BioMedical Engineering OnLine 2021 20:24
    Content type: Review Published on:

  2. The large volume and suboptimal image quality of portable chest X-rays (CXRs) as a result of the COVID-19 pandemic could post significant challenges for radiologists and frontline physicians. Deep-learning art...

    Authors: Lal Hussain, Tony Nguyen, Haifang Li, Adeel A. Abbasi, Kashif J. Lone, Zirun Zhao, Mahnoor Zaib, Anne Chen and Tim Q. Duong
    Citation: BioMedical Engineering OnLine 2020 19:88
    Content type: Research Published on:

  3. Functional electrical stimulation is a technique to produce functional movements after paralysis. Electrical discharges are applied to a person’s muscles making them contract in a sequence that allows performi...

    Authors: Cesar Marquez-Chin and Milos R. Popovic
    Citation: BioMedical Engineering OnLine 2020 19:34
    Content type: Review Published on:

  4. The organ-on-a-chip (OOAC) is in the list of top 10 emerging technologies and refers to a physiological organ biomimetic system built on a microfluidic chip. Through a combination of cell biology, engineering,...

    Authors: Qirui Wu, Jinfeng Liu, Xiaohong Wang, Lingyan Feng, Jinbo Wu, Xiaoli Zhu, Weijia Wen and Xiuqing Gong
    Citation: BioMedical Engineering OnLine 2020 19:9
    Content type: Review Published on:

  5. Non-invasive discrimination between lung squamous cell carcinoma (LUSC) and lung adenocarcinoma (LUAD) subtypes of non-small-cell lung cancer (NSCLC) could be very beneficial to the patients unfit for the inva...

    Authors: Xing Tang, Xiaopan Xu, Zhiping Han, Guoyan Bai, Hong Wang, Yang Liu, Peng Du, Zhengrong Liang, Jian Zhang, Hongbing Lu and Hong Yin
    Citation: BioMedical Engineering OnLine 2020 19:5
    Content type: Research Published on:

  6. The surgical success of cementless implants is determined by the evolution of the biomechanical properties of the bone–implant interface (BII). One difficulty to model the biomechanical behavior of the BII com...

    Authors: Maria Letizia Raffa, Vu-Hieu Nguyen and Guillaume Haiat
    Citation: BioMedical Engineering OnLine 2019 18:114
    Content type: Research Published on:

  7. Silk fibroin hydrogel, derived from Bombyx mori cocoons, has been shown to have potential effects on wound healing due to its excellent biocompatibility and less immunogenic and biodegradable properties. Many stu...

    Authors: Sirong He, Dan Shi, Zhigang Han, Zhaoming Dong, Yajun Xie, Fengmei Zhang, WenXin Zeng and Qiying Yi
    Citation: BioMedical Engineering OnLine 2019 18:97
    Content type: Research Published on:

  10. Docetaxel (DTX) is an anticancer drug that is currently formulated with polysorbate 80 and ethanol (50:50, v/v) in clinical use. Unfortunately, this formulation causes hypersensitivity reactions, leading to se...

    Authors: Na Qu, Yating Sun, Yujing Li, Fei Hao, Pengyu Qiu, Lesheng Teng, Jing Xie and Yin Gao
    Citation: BioMedical Engineering OnLine 2019 18:11
    Content type: Research Published on:

  11. Acute myocardial infarction (AMI) is the common cause of mortality in developed countries. The feasibility of whole-genome gene expression analysis to identify outcome-related genes and dysregulated pathways r...

    Authors: Zhihua Liu, Chenguang Ma, Junhua Gu and Ming Yu
    Citation: BioMedical Engineering OnLine 2019 18:9
    Content type: Research Published on:

  12. Lung segmentation constitutes a critical procedure for any clinical-decision supporting system aimed to improve the early diagnosis and treatment of lung diseases. Abnormal lungs mainly include lung parenchyma...

    Authors: Mingjie Xu, Shouliang Qi, Yong Yue, Yueyang Teng, Lisheng Xu, Yudong Yao and Wei Qian
    Citation: BioMedical Engineering OnLine 2019 18:2
    Content type: Research Published on:

  15. Since falls are a major public health problem among older people, the number of systems aimed at detecting them has increased dramatically over recent years. This work presents an extensive literature review o...

    Authors: Raul Igual, Carlos Medrano and Inmaculada Plaza
    Citation: BioMedical Engineering OnLine 2013 12:66
    Content type: Review Published on:

  16. Therapeutic irreversible electroporation (IRE) is an emerging technology for the non-thermal ablation of tumors. The technique involves delivering a series of unipolar electric pulses to permanently destabiliz...

    Authors: Christopher B Arena, Michael B Sano, John H Rossmeisl Jr, John L Caldwell, Paulo A Garcia, Marissa Nichole Rylander and Rafael V Davalos
    Citation: BioMedical Engineering OnLine 2011 10:102
    Content type: Research Published on:

  17. The latest generation of smartphones are increasingly viewed as handheld computers rather than as phones, due to their powerful on-board computing capability, capacious memories, large screens and open operati...

    Authors: Maged N Kamel Boulos, Steve Wheeler, Carlos Tavares and Ray Jones
    Citation: BioMedical Engineering OnLine 2011 10:24
    Content type: Review Published on:

  18. Interpreting and controlling bioelectromagnetic phenomena require realistic physiological models and accurate numerical solvers. A semi-realistic model often used in practise is the piecewise constant conducti...

    Authors: Alexandre Gramfort, Théodore Papadopoulo, Emmanuel Olivi and Maureen Clerc
    Citation: BioMedical Engineering OnLine 2010 9:45
    Content type: Research Published on:

  19. Abdominal aortic aneurysm (AAA) is a dilatation of the aortic wall, which can rupture, if left untreated. Previous work has shown that, maximum diameter is not a reliable determinant of AAA rupture. However, i...

    Authors: James H Leung, Andrew R Wright, Nick Cheshire, Jeremy Crane, Simon A Thom, Alun D Hughes and Yun Xu
    Citation: BioMedical Engineering OnLine 2006 5:33
    Content type: Research Published on: