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BMC Medicine Reviews 2017

This list will be updated with all new review articles published in BMC Medicine. All of our articles are open access and therefore free to read and share.

  1. Review

    Is Graves’ disease a primary immunodeficiency? New immunological perspectives on an endocrine disease

    Uncertainty about factors influencing the susceptibility and triggers for Graves’ disease persists, along with a wide variation in the response to anti-thyroid drugs, currently at approximately 50% of non-resp...

    Tristan Struja, Alexander Kutz, Stefan Fischli, Christian Meier, Beat Mueller, Mike Recher and Philipp Schuetz

    BMC Medicine 2017 15:174

    Published on: 25 September 2017

  2. Minireview

    What makes gouty inflammation so variable?

    Acute gout arthritis flares contribute dominantly to gout-specific impaired health-related quality of life, representing a progressively increasing public health problem. Flares can be complex and expensive to...

    Robert Terkeltaub

    BMC Medicine 2017 15:158

    Published on: 18 August 2017

  3. Review

    The renin–angiotensin system: a possible new target for depression

    Depression remains a debilitating condition with an uncertain aetiology. Recently, attention has been given to the renin–angiotensin system. In the central nervous system, angiotensin II may be important in mu...

    João Vian, Círia Pereira, Victor Chavarria, Cristiano Köhler, Brendon Stubbs, João Quevedo, Sung-Wan Kim, André F. Carvalho, Michael Berk and Brisa S. Fernandes

    BMC Medicine 2017 15:144

    Published on: 1 August 2017

  4. Minireview

    The genetics of gout: towards personalised medicine?

    Over the last decade, there have been major advances in the understanding of the genetic basis of hyperuricaemia and gout as well as of the pharmacogenetics of urate-lowering therapy. Key findings include the ...

    Nicola Dalbeth, Lisa K. Stamp and Tony R. Merriman

    BMC Medicine 2017 15:108

    Published on: 31 May 2017

  5. Minireview

    When less may be more: calorie restriction and response to cancer therapy

    Calorie restriction (CR) extends lifespan and has been shown to reduce age-related diseases including cancer, diabetes, and cardiovascular and neurodegenerative diseases in experimental models. Recent translat...

    Ciara H. O’Flanagan, Laura A. Smith, Shannon B. McDonell and Stephen D. Hursting

    BMC Medicine 2017 15:106

    Published on: 24 May 2017

  6. Review

    Emerging concepts in liquid biopsies

    Characterizing and monitoring tumor genomes with blood samples could achieve significant improvements in precision medicine. As tumors shed parts of themselves into the circulation, analyses of circulating tum...

    Samantha Perakis and Michael R. Speicher

    BMC Medicine 2017 15:75

    Published on: 6 April 2017

  7. Minireview

    Elimination of Hepatitis B: Is It a Mission Possible?

    Chronic hepatitis B virus (HBV) infection is a global public health issue. Although the disease cannot be cured effectively, disease management has been improved over the past decade. The introduction of poten...

    Tai-Chung Tseng and Jia-Horng Kao

    BMC Medicine 2017 15:53

    Published on: 15 March 2017

  8. Minireview

    Successes and failures: what did we learn from recent first-line treatment immunotherapy trials in non-small cell lung cancer?

    Immune checkpoint inhibitors have significantly modified the therapeutic landscape of advanced non-small cell lung cancer in second-line settings, with a more recent advancement in first-line settings. Given t...

    Jordi Remon, Benjamin Besse and Jean-Charles Soria

    BMC Medicine 2017 15:55

    Published on: 13 March 2017

    The Erratum to this article has been published in BMC Medicine 2017 15:82

  9. Review

    Genetics of vascular dementia – review from the ICVD working group

    Vascular dementia is a common disorder resulting in considerable morbidity and mortality. Determining the extent to which genes play a role in disease susceptibility and their pathophysiological mechanisms cou...

    M. Arfan Ikram, Anna Bersano, Raquel Manso-Calderón, Jian-Ping Jia, Helena Schmidt, Lefkos Middleton, Benedetta Nacmias, Saima Siddiqi and Hieab H.H. Adams

    BMC Medicine 2017 15:48

    Published on: 6 March 2017

  10. Minireview

    Non-alcoholic fatty liver disease

    Non-alcoholic fatty liver disease has emerged a major challenge because of it prevalence, difficulties in diagnosis, complex pathogenesis, and lack of approved therapies. As the burden of hepatitis C abates ov...

    Brent A. Neuschwander-Tetri

    BMC Medicine 2017 15:45

    Published on: 28 February 2017

  11. Review

    Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) as a model of small vessel disease: update on clinical, diagnostic, and management aspects

    Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common and best known monogenic small vessel disease. Here, we review the clinical, neuroimaging...

    Ilaria Di Donato, Silvia Bianchi, Nicola De Stefano, Martin Dichgans, Maria Teresa Dotti, Marco Duering, Eric Jouvent, Amos D. Korczyn, Saskia A. J. Lesnik-Oberstein, Alessandro Malandrini, Hugh S. Markus, Leonardo Pantoni, Silvana Penco, Alessandra Rufa, Osman Sinanović, Dragan Stojanov…

    BMC Medicine 2017 15:41

    Published on: 24 February 2017

  12. Review

    Ultrasound and dynamic functional imaging in vascular cognitive impairment and Alzheimer’s disease

    The vascular contributions to neurodegeneration and neuroinflammation may be assessed by magnetic resonance imaging (MRI) and ultrasonography (US). This review summarises the methodology for these widely avail...

    Branko Malojcic, Panteleimon Giannakopoulos, Farzaneh A. Sorond, Elsa Azevedo, Marina Diomedi, Janja Pretnar Oblak, Nicola Carraro, Marina Boban, Laszlo Olah, Stephan J. Schreiber, Aleksandra Pavlovic, Zsolt Garami, Nantan M. Bornstein and Bernhard Rosengarten

    BMC Medicine 2017 15:27

    Published on: 9 February 2017

  13. Minireview

    Translational models for vascular cognitive impairment: a review including larger species

    Disease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we revie...

    Atticus H. Hainsworth, Stuart M. Allan, Johannes Boltze, Catriona Cunningham, Chad Farris, Elizabeth Head, Masafumi Ihara, Jeremy D. Isaacs, Raj N. Kalaria, Saskia A. M. J. Lesnik Oberstein, Mark B. Moss, Björn Nitzsche, Gary A. Rosenberg, Julie W. Rutten, Melita Salkovic-Petrisic and Aron M. Troen

    BMC Medicine 2017 15:16

    Published on: 25 January 2017

  14. Minireview

    Procalcitonin-guided diagnosis and antibiotic stewardship revisited

    Several controlled clinical studies have evaluated the potential of the infection biomarker procalcitonin (PCT) to improve the diagnostic work-up of patients with bacterial infections and its influence on deci...

    Ramon Sager, Alexander Kutz, Beat Mueller and Philipp Schuetz

    BMC Medicine 2017 15:15

    Published on: 24 January 2017

  15. Review

    Post-stroke dementia – a comprehensive review

    Post-stroke dementia (PSD) or post-stroke cognitive impairment (PSCI) may affect up to one third of stroke survivors. Various definitions of PSCI and PSD have been described. We propose PSD as a label for any ...

    Milija D. Mijajlović, Aleksandra Pavlović, Michael Brainin, Wolf-Dieter Heiss, Terence J. Quinn, Hege B. Ihle-Hansen, Dirk M. Hermann, Einor Ben Assayag, Edo Richard, Alexander Thiel, Efrat Kliper, Yong-Il Shin, Yun-Hee Kim, SeongHye Choi, San Jung, Yeong-Bae Lee…

    BMC Medicine 2017 15:11

    Published on: 18 January 2017