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BMC Biology Reviews

Iconic imageBMC Biology publishes authoritative reviews on diverse topics. All reviews are open access and therefore free to read and share.

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  1. There is increasing evidence that all cells sense mechanical forces in order to perform their functions. In animals, mechanotransduction has been studied during the establishment of cell polarity, fate, and di...

    Authors: Olivier Hamant and Elizabeth S. Haswell
    Citation: BMC Biology 2017 15:59
    Content type: Review Published on:

  2. Macrophages are present in all vertebrate tissues, from mid-gestation throughout life, constituting a widely dispersed organ system. They promote homeostasis by responding to internal and external changes with...

    Authors: Siamon Gordon and Annette Plüddemann
    Citation: BMC Biology 2017 15:53
    Content type: Review Published on:

  6. Probing dynamic processes occurring within the cell nucleus at the quantitative level has long been a challenge in mammalian biology. Advances in bio-imaging techniques over the past decade have enabled us to ...

    Authors: Ziqing W. Zhao, Melanie D. White, Stephanie Bissiere, Valeria Levi and Nicolas Plachta
    Citation: BMC Biology 2016 14:115
    Content type: Review Published on:

  7. In his splendid article “Can a biologist fix a radio? — or, what I learned while studying apoptosis,” Y. Lazebnik argues that when one uses the right tools, similarity between a biological system, like a signa...

    Authors: Mustafa Khammash
    Citation: BMC Biology 2016 14:22
    Content type: Review Published on:

  12. The rod is a ubiquitous shape adopted by walled cells from diverse organisms ranging from bacteria to fungi to plants. Although rod-like shapes are found in cells of vastly different sizes and are constructed ...

    Authors: Fred Chang and Kerwyn Casey Huang
    Citation: BMC Biology 2014 12:54
    Content type: Review Published on:

  13. In a majority of cell types, mitochondria form highly dynamic, tubular networks. Maintaining the shape of this complex network is critical for both mitochondrial and cellular function and involves the activiti...

    Authors: Laura L Lackner
    Citation: BMC Biology 2014 12:35
    Content type: Review Published on:

  14. Almost 20 years ago, the discovery that mitochondrial release of cytochrome c initiates a cascade that leads to cell death brought about a wholesale change in how cell biologists think of mitochondria. Formerl...

    Authors: Navdeep S Chandel
    Citation: BMC Biology 2014 12:34
    Content type: Review Published on:

  16. The new field of viral dynamics, based on within-host modeling of viral infections, began with models of human immunodeficiency virus (HIV), but now includes many viral infections. Here we review developments ...

    Authors: Alan S Perelson and Ruy M Ribeiro
    Citation: BMC Biology 2013 11:96
    Content type: Review Published on:

  17. The posttranslational modification of target proteins with ubiquitin and ubiquitin-like proteins is accomplished by the sequential action of E1, E2, and E3 enzymes. Members of the E1 and E3 enzyme families can...

    Authors: Sonja Lorenz, Aaron J Cantor, Michael Rape and John Kuriyan
    Citation: BMC Biology 2013 11:65
    Content type: Review Published on:

  18. Long non-protein-coding RNAs (lncRNAs) are proposed to be the largest transcript class in the mouse and human transcriptomes. Two important questions are whether all lncRNAs are functional and how they could e...

    Authors: Aleksandra E Kornienko, Philipp M Guenzl, Denise P Barlow and Florian M Pauler
    Citation: BMC Biology 2013 11:59
    Content type: Review Published on:

  19. First discovered in Drosophila, the Hedgehog signaling pathway controls a wide range of developmental processes and is implicated in a variety of cancers. The success of a screen for chemical modulators of this p...

    Authors: Tom J Carney and Philip W Ingham
    Citation: BMC Biology 2013 11:37
    Content type: Review Published on: