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BMC Biology - 20th anniversary

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To celebrate BMC Biology's 20th anniversary, here we bring together perspective articles on the past and future of their fields from those who have shared our journey, alongside a selection of our most highly accessed papers. We hope you join us in marking this occasion and that you consider submitting your next manuscript to BMC Biology.

 

  6. The last two decades have seen impressive advances in functional genomics, but we are still a long way from understanding the complexity of gene function. Here, we pose questions on how much is currently known ab...

    Authors: Lydia Teboul, Yann Hérault, Sara Wells and Guillaume Pavlovic
    Citation: BMC Biology 2023 21:301
    Content type: Comment Published on:

  10. Recent progress in adult stem cell technology, along with interdisciplinary collaboration in the field of One Health, has accelerated the development of 3D organoid cultures in non-model animals, such as dogs....

    Authors: Karin Allenspach, Yana Zavros, Mohamed Elbadawy, Christopher Zdyrski and Jonathan Paul Mochel
    Citation: BMC Biology 2023 21:297
    Content type: Comment Published on:

  11. Modeling networks for single samples can facilitate discoveries in biology that go beyond those found when analyzing an “aggregate” network, i.e., one that merges information across all the samples in an omics...

    Authors: Margherita De Marzio, Kimberly Glass and Marieke L. Kuijjer
    Citation: BMC Biology 2023 21:296
    Content type: Comment Published on:

  16. RNA 5-methyluridine (m5U) modifications are obtained by methylation at the C5 position of uridine catalyzed by pyrimidine methylation transferase, which is related to the development of human diseases. Accurate i...

    Authors: Chunyan Ao, Xiucai Ye, Tetsuya Sakurai, Quan Zou and Liang Yu
    Citation: BMC Biology 2023 21:93
    Content type: Methodology article Published on:

  17. Fishes are the one of the most diverse groups of animals with respect to their modes of sex determination, providing unique models for uncovering the evolutionary and molecular mechanisms underlying sex determ...

    Authors: Le Wang, Fei Sun, Zi Yi Wan, Zituo Yang, Yi Xuan Tay, May Lee, Baoqing Ye, Yanfei Wen, Zining Meng, Bin Fan, Yuzer Alfiko, Yubang Shen, Francesc Piferrer, Axel Meyer, Manfred Schartl and Gen Hua Yue
    Citation: BMC Biology 2022 20:5
    Content type: Research article Published on:

  18. A robust molecular phylogeny is fundamental for developing a stable classification and providing a solid framework to understand patterns of diversification, historical biogeography, and character evolution. A...

    Authors: Fei Zhao, Ya-Ping Chen, Yasaman Salmaki, Bryan T. Drew, Trevor C. Wilson, Anne-Cathrine Scheen, Ferhat Celep, Christian Bräuchler, Mika Bendiksby, Qiang Wang, Dao-Zhang Min, Hua Peng, Richard G. Olmstead, Bo Li and Chun-Lei Xiang
    Citation: BMC Biology 2021 19:2
    Content type: Research article Published on:

  19. Parkinson’s disease (PD) is a systemic disease clinically defined by the degeneration of dopaminergic neurons in the brain. While alterations in the gut microbiome composition have been reported in PD, their f...

    Authors: Federico Baldini, Johannes Hertel, Estelle Sandt, Cyrille C. Thinnes, Lorieza Neuberger-Castillo, Lukas Pavelka, Fay Betsou, Rejko Krüger and Ines Thiele
    Citation: BMC Biology 2020 18:62
    Content type: Research article Published on:

  20. CRISPR-Cas12a (formerly Cpf1) is an RNA-guided endonuclease with distinct features that have expanded genome editing capabilities. Cas12a-mediated genome editing is temperature sensitive in plants, but a lack ...

    Authors: Aimee A. Malzahn, Xu Tang, Keunsub Lee, Qiurong Ren, Simon Sretenovic, Yingxiao Zhang, Hongqiao Chen, Minjeong Kang, Yu Bao, Xuelian Zheng, Kejun Deng, Tao Zhang, Valeria Salcedo, Kan Wang, Yong Zhang and Yiping Qi
    Citation: BMC Biology 2019 17:9
    Content type: Research article Published on:

  21. Tunicates are the closest relatives of vertebrates and are widely used as models to study the evolutionary developmental biology of chordates. Their phylogeny, however, remains poorly understood, and to date, ...

    Authors: Frédéric Delsuc, Hervé Philippe, Georgia Tsagkogeorga, Paul Simion, Marie-Ka Tilak, Xavier Turon, Susanna López-Legentil, Jacques Piette, Patrick Lemaire and Emmanuel J. P. Douzery
    Citation: BMC Biology 2018 16:39
    Content type: Research article Published on:

  22. Helicoverpa armigera and Helicoverpa zea are major caterpillar pests of Old and New World agriculture, respectively. Both, particularly H. armigera, are extremely polyphagous, and H. a...

    Authors: S. L. Pearce, D. F. Clarke, P. D. East, S. Elfekih, K. H. J. Gordon, L. S. Jermiin, A. McGaughran, J. G. Oakeshott, A. Papanikolaou, O. P. Perera, R. V. Rane, S. Richards, W. T. Tay, T. K. Walsh, A. Anderson, C. J. Anderson…
    Citation: BMC Biology 2017 15:63
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Biology 2017 15:69

  23. In February 2016, a new fungal disease was spotted in wheat fields across eight districts in Bangladesh. The epidemic spread to an estimated 15,000 hectares, about 16 % of the cultivated wheat area in Banglade...

    Authors: M. Tofazzal Islam, Daniel Croll, Pierre Gladieux, Darren M. Soanes, Antoine Persoons, Pallab Bhattacharjee, Md. Shaid Hossain, Dipali Rani Gupta, Md. Mahbubur Rahman, M. Golam Mahboob, Nicola Cook, Moin U. Salam, Musrat Zahan Surovy, Vanessa Bueno Sancho, João Leodato Nunes Maciel, Antonio NhaniJúnior…
    Citation: BMC Biology 2016 14:84
    Content type: Research article Published on:

  25. The study of microbial communities has been revolutionised in recent years by the widespread adoption of culture independent analytical techniques such as 16S rRNA gene sequencing and metagenomics. One potenti...

    Authors: Susannah J Salter, Michael J Cox, Elena M Turek, Szymon T Calus, William O Cookson, Miriam F Moffatt, Paul Turner, Julian Parkhill, Nicholas J Loman and Alan W Walker
    Citation: BMC Biology 2014 12:87
    Content type: Research article Published on:

  26. The intestinal mucus layer plays a key role in the maintenance of host-microbiota homeostasis. To document the crosstalk between the host and microbiota, we used gnotobiotic models to study the influence of tw...

    Authors: Laura Wrzosek, Sylvie Miquel, Marie-Louise Noordine, Stephan Bouet, Marie Joncquel Chevalier-Curt, Véronique Robert, Catherine Philippe, Chantal Bridonneau, Claire Cherbuy, Catherine Robbe-Masselot, Philippe Langella and Muriel Thomas
    Citation: BMC Biology 2013 11:61
    Content type: Research article Published on:

  27. There is overwhelming evidence that in vitro three-dimensional tumor cell cultures more accurately reflect the complex in vivo microenvironment than simple two-dimensional cell monolayers, not least with respect ...

    Authors: Maria Vinci, Sharon Gowan, Frances Boxall, Lisa Patterson, Miriam Zimmermann, William Court, Cara Lomas, Marta Mendiola, David Hardisson and Suzanne A Eccles
    Citation: BMC Biology 2012 10:29
    Content type: Methodology article Published on:

  28. Understanding how biodiversity is shaped through time is a fundamental question in biology. Even though tropical rain forests (TRF) represent the most diverse terrestrial biomes on the planet, the timing, loca...

    Authors: Thomas LP Couvreur, Félix Forest and William J Baker
    Citation: BMC Biology 2011 9:44
    Content type: Research article Published on:

  29. Relaxed molecular clock models allow divergence time dating and "relaxed phylogenetic" inference, in which a time tree is estimated in the face of unequal rates across lineages. We present a new method for rel...

    Authors: Alexei J Drummond and Marc A Suchard
    Citation: BMC Biology 2010 8:114
    Content type: Research article Published on:

  30. Membrane proteins form key nodes in mediating the cell's interaction with the surroundings, which is one of the main reasons why the majority of drug targets are membrane proteins.

    Authors: Markus Sällman Almén, Karl JV Nordström, Robert Fredriksson and Helgi B Schiöth
    Citation: BMC Biology 2009 7:50
    Content type: Research article Published on:

  31. Inherited bacteria have come to be recognised as important components of arthropod biology. In addition to mutualistic symbioses, a range of other inherited bacteria are known to act either as reproductive par...

    Authors: Olivier Duron, Didier Bouchon, Sébastien Boutin, Lawrence Bellamy, Liqin Zhou, Jan Engelstädter and Gregory D Hurst
    Citation: BMC Biology 2008 6:27
    Content type: Research article Published on:

  33. TBLASTN is a mode of operation for BLAST that aligns protein sequences to a nucleotide database translated in all six frames. We present the first description of the modern implementation of TBLASTN, focusing ...

    Authors: E Michael Gertz, Yi-Kuo Yu, Richa Agarwala, Alejandro A Schäffer and Stephen F Altschul
    Citation: BMC Biology 2006 4:41
    Content type: Methodology article Published on:

  34. It is a matter of ongoing debate whether a universal species concept is possible for bacteria. Indeed, it is not clear whether closely related isolates of bacteria typically form discrete genotypic clusters th...

    Authors: William P Hanage, Christophe Fraser and Brian G Spratt
    Citation: BMC Biology 2005 3:6
    Content type: Research article Published on:

  36. RNA silencing processes are widespread in almost all eukaryotic organisms. They have various functions including genome protection, and the control of gene expression, development and heterochromatin formation...

    Authors: Mickaël Durand-Dubief and Philippe Bastin
    Citation: BMC Biology 2003 1:2
    Content type: Research article Published on:
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