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The biology of mood and anxiety disorders

 We are witnessing a dramatic shift in the foundations of mental health and psychiatry, where research into the biological underpinnings of psychopathology is becoming increasingly important. This article collection aims to focus on all areas relevant to the mood and anxiety disorders at the level of their underlying mechanisms, including but not limited to: pathophysiology, predictive risk markers, treatment predictors, individual differences and developmental trajectories of mood and anxiety disorders. We welcome further research submissions on these topics. If you would like to submit your manuscript for consideration in the series, please contact

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  1. The habenula plays an important role in regulating behavioral responses to stress and shows increased cerebral blood flow and decreased gray matter volume in patients with mood disorders. Here, we compare the ...

    Authors: Jonathan B Savitz, Omer Bonne, Allison C Nugent, Meena Vythilingam, Wendy Bogers, Dennis S Charney and Wayne C Drevets
    Citation: Biology of Mood & Anxiety Disorders 2011 1:7
  2. Exposure to combat can have a significant impact across a wide array of domains, and may manifest as post-traumatic stress disorder (PTSD), a debilitating mental illness that is associated with neural and affe...

    Authors: Alan N Simmons, Scott C Matthews, Irina A Strigo, Dewleen G Baker, Heather K Donovan, Arame Motezadi, Murray B Stein and Martin P Paulus
    Citation: Biology of Mood & Anxiety Disorders 2011 1:6
  3. Despite the sparseness of the currently available data, there is accumulating evidence of information processing impairment in post-traumatic stress disorder (PTSD). Studies of event-related potentials (ERPs) ...

    Authors: Arash Javanbakht, Israel Liberzon, Alireza Amirsadri, Klevest Gjini and Nash N Boutros
    Citation: Biology of Mood & Anxiety Disorders 2011 1:5
  4. Administration of exogenous corticosterone is an effective preclinical model of depression, but its use has involved primarily adult rodents. Using two different procedures of administration drawn from the lit...

    Authors: Patti Waters and Cheryl M McCormick
    Citation: Biology of Mood & Anxiety Disorders 2011 1:4
  5. Fractional anisotropy anomalies occurring in the white matter tracts in the brains of depressed patients may reflect microstructural changes underlying the pathophysiology of this disorder. We conducted a meta...

    Authors: Melissa L Murphy and Thomas Frodl
    Citation: Biology of Mood & Anxiety Disorders 2011 1:3
  6. The amygdala and medial prefrontal cortex (mPFC) comprise a key corticolimbic circuit that helps shape individual differences in sensitivity to threat and the related risk for psychopathology. Although seroton...

    Authors: Patrick M Fisher, Julie C Price, Carolyn C Meltzer, Eydie L Moses-Kolko, Carl Becker, Sarah L Berga and Ahmad R Hariri
    Citation: Biology of Mood & Anxiety Disorders 2011 1:2