Skip to main content


Peripheral biomarkers

This Peripheral biomarkers special series, published in Alzheimer's Research & Therapy, tackles the current issues surrounding the search to identify blood biomarkers for Alzheimer’s disease and discusses biomarker approaches that have already produced data that may help to advance the field.

This series of articles has not been sponsored. All articles have undergone the journal’s standard peer review process overseen by the Series Editor, with final decisions made by the Editors in Chief. The Series Editor and Editors in Chief declare no competing interests.

  1. Review

    Circulating biomarkers that predict incident dementia

    Dementia is currently diagnosed based on clinical symptoms and signs, but significant brain damage has already occurred by the time a clinical diagnosis of dementia is made, and it is increasingly recognized t...

    Galit Weinstein and Sudha Seshadri

    Alzheimer's Research & Therapy 2014 6:6

    Published on: 21 January 2014

  2. Research

    Calmodulin levels in blood cells as a potential biomarker of Alzheimer’s disease

    The clinical features of Alzheimer’s disease (AD) overlap with a number of other dementias and conclusive diagnosis is only achieved at autopsy. Accurate in-life diagnosis requires finding biomarkers suitable ...

    Noemí Esteras, Carolina Alquézar, Ana de la Encarnación, Alberto Villarejo, Félix Bermejo-Pareja and Ángeles Martín-Requero

    Alzheimer's Research & Therapy 2013 5:55

    Published on: 7 November 2013

  3. Review

    Multiplex biomarkers in blood

    Advances in the field of blood biomarker discovery will help in identifying Alzheimer's disease in its preclinical stage, allowing treatment to be initiated before irreversible damage occurs. This review discu...

    Veer Bala Gupta, Ramani Sundaram and Ralph N Martins

    Alzheimer's Research & Therapy 2013 5:31

    Published on: 25 June 2013

  4. Research

    Exploring the potential of the platelet membrane proteome as a source of peripheral biomarkers for Alzheimer's disease

    Peripheral biomarkers to diagnose Alzheimer's disease (AD) have not been established. Given parallels between neuron and platelet biology, we hypothesized platelet membrane-associated protein changes may diffe...

    Laura E Donovan, Eric B Dammer, Duc M Duong, John J Hanfelt, Allan I Levey, Nicholas T Seyfried and James J Lah

    Alzheimer's Research & Therapy 2013 5:32

    Published on: 13 June 2013

  5. Review

    Advances in blood-based protein biomarkers for Alzheimer's disease

    Alzheimer's disease (AD) is a neurodegenerative disorder that accounts for the majority of dementia cases. While research over the past decades has made advances into understanding disease pathology, definite ...

    Lorraine Fuhrmann Clark and Thomas Kodadek

    Alzheimer's Research & Therapy 2013 5:18

    Published on: 9 May 2013