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Bioelectronic medicine: engineering advances, physiological insights, and translational applications

New Content ItemEdited by Stavros Zanos, Timir Datta-Chaudhuri, Vasiliki Giagka, Loren Rieth, and Theodoros Zanos

The field of Bioelectronic Medicine has grown significantly in the last decade, in both academia and industry.  It is an intrinsically multidisciplinary field and therefore advances require collaboration across diverse areas of expertise. At the core of the field lies the concept of electrically interfacing with the nervous system to modulate and control the immune response and the physiological state of organs and systems. The field necessarily draws from numerous fields of research, including:

  • development of peripheral nerve electrodes and biological interfaces
  • stimulation techniques and technologies for organ- and fiber-specific neuromodulation
  • systems and algorithms for closed-loop neurostimulation
  • electronics and implantable devices that enable wired or wireless operation, including powering and communication
  • techniques for signal processing and machine learning to study the relationship between nerve signals and physiological function
  • validation of these systems in preclinical models of disease

For this thematic series we would like to invite original contributions and reviews in the following areas:

1. Novel neural interfaces

  • Electrode materials, fabrication, and validation
  • Electrode-tissue interface and tissue response
  • In vivo sensors of immune, metabolic, neural, and cardiovascular biomarkers

2. Methods, systems, and applications of targeted neuromodulation

  • Organ- and fiber type-specific neurostimulation
  • Optical stimulation
  • Ultrasonic neuromodulation systems
  • Closed-loop bioelectronic systems
  • Applications of targeted neuromodulation

3. Advances in bioelectronic data analytics

  • Decoding of nerve activity
  • Artifact rejection and signal-processing methods
  • Bandwidth reduction and high-throughput techniques

4. New implantable bioelectronic devices

  • System integration and packaging development and validation
  • Wireless power and telemetry
  • Device miniaturization for small rodents

5. Translation of bioelectronic therapies

  • Acute electrode evaluation of safety and efficacy of novel technologies
  • Chronic lifetime and performance
  • Bioelectronic therapies in animal models of metabolic, cardiovascular, and neurological disorders
  • Implications for clinical translation

Series keywords: Bioelectronics; Neural interfaces; Targeted neuromodulation; Closed-loop neuromodulation; Data analytics; Implantable devices; Animal models of disease; Translational medicine applications

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

You can submit to this series, here.

  1. Noninvasive ultrasound (US) has been used therapeutically for decades, with applications in tissue ablation, lithotripsy, and physical therapy. There is increasing evidence that low intensity US stimulation of...

    Authors: Claire R. W. Kaiser, Adam B. Tuma, Maryam Zebarjadi, Daniel P. Zachs, Anna J. Organ, Hubert H. Lim and Morgan N. Collins
    Citation: Bioelectronic Medicine 2023 9:25
  2. Autonomic nerve stimulation is used as a treatment for a growing number of diseases. We have previously demonstrated that application of efferent vagus nerve stimulation (eVNS) has promising glucose lowering e...

    Authors: Joel Villalobos, Sophie C. Payne, Glenn M. Ward, Sofianos Andrikopoulos, Tomoko Hyakumura, Richard J. MacIsaac and James B. Fallon
    Citation: Bioelectronic Medicine 2023 9:16
  3. Microelectrode arrays (MEA) enable the measurement and stimulation of the electrical activity of cultured cells. The integration of other neuromodulation methods will significantly enhance the application rang...

    Authors: Marta Saccher, Shinnosuke Kawasaki, Martina Proietti Onori, Geeske M. van Woerden, Vasiliki Giagka and Ronald Dekker
    Citation: Bioelectronic Medicine 2022 8:2
  4. In the past three decades, we have witnessed unprecedented progress in wireless implantable medical devices that can monitor physiological parameters and interface with the nervous system. These devices are be...

    Authors: Adam Khalifa, Sunwoo Lee, Alyosha Christopher Molnar and Sydney Cash
    Citation: Bioelectronic Medicine 2021 7:19
  5. This paper describes a method to reversibly block nerve conduction through direct application of a 1 Hz sinusoidal current waveform delivered through a bipolar nerve cuff electrode. This low frequency alternat...

    Authors: Maria Ivette Muzquiz, Lindsay Richardson, Christian Vetter, Macallister Smolik, Awadh Alhawwash, Adam Goodwill, Rizwan Bashirullah, Michael Carr and Ken Yoshida
    Citation: Bioelectronic Medicine 2021 7:9
  6. Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piez...

    Authors: Tao Sun, Jason Wright and Timir Datta-Chaudhuri
    Citation: Bioelectronic Medicine 2020 6:16

    The original article was published in Bioelectronic Medicine 2020 6:13

  7. Efficient identification of effective neurostimulation strategies is critical due to the growing number of clinical applications and the increasing complexity of the corresponding technology. In consequence, i...

    Authors: Marco Capogrosso and Scott F. Lempka
    Citation: Bioelectronic Medicine 2020 6:10
  8. Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...

    Authors: Amparo Güemes Gonzalez, Ralph Etienne-Cummings and Pantelis Georgiou
    Citation: Bioelectronic Medicine 2020 6:11
  9. The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...

    Authors: Imran S. Qureshi, Timir Datta-Chaudhuri, Kevin J. Tracey, Valentin A. Pavlov and Andrew C. H. Chen
    Citation: Bioelectronic Medicine 2020 6:7
  10. Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...

    Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev
    Citation: Bioelectronic Medicine 2020 6:4

    The Correction to this article has been published in Bioelectronic Medicine 2020 6:6