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Bioelectronic medicine: engineering advances, physiological insights, and translational applications

New Content ItemEdited by Stavros Zanos, Timir Datta-Chaudhuri, Vasiliki Giagka, Loren Rieth, and Theodoros Zanos

The field of Bioelectronic Medicine has grown significantly in the last decade, in both academia and industry.  It is an intrinsically multidisciplinary field and therefore advances require collaboration across diverse areas of expertise. At the core of the field lies the concept of electrically interfacing with the nervous system to modulate and control the immune response and the physiological state of organs and systems. The field necessarily draws from numerous fields of research, including:

  • development of peripheral nerve electrodes and biological interfaces
  • stimulation techniques and technologies for organ- and fiber-specific neuromodulation
  • systems and algorithms for closed-loop neurostimulation
  • electronics and implantable devices that enable wired or wireless operation, including powering and communication
  • techniques for signal processing and machine learning to study the relationship between nerve signals and physiological function
  • validation of these systems in preclinical models of disease

For this thematic series we would like to invite original contributions and reviews in the following areas:

1. Novel neural interfaces

  • Electrode materials, fabrication, and validation
  • Electrode-tissue interface and tissue response
  • In vivo sensors of immune, metabolic, neural, and cardiovascular biomarkers

2. Methods, systems, and applications of targeted neuromodulation

  • Organ- and fiber type-specific neurostimulation
  • Optical stimulation
  • Ultrasonic neuromodulation systems
  • Closed-loop bioelectronic systems
  • Applications of targeted neuromodulation

3. Advances in bioelectronic data analytics

  • Decoding of nerve activity
  • Artifact rejection and signal-processing methods
  • Bandwidth reduction and high-throughput techniques

4. New implantable bioelectronic devices

  • System integration and packaging development and validation
  • Wireless power and telemetry
  • Device miniaturization for small rodents

5. Translation of bioelectronic therapies

  • Acute electrode evaluation of safety and efficacy of novel technologies
  • Chronic lifetime and performance
  • Bioelectronic therapies in animal models of metabolic, cardiovascular, and neurological disorders
  • Implications for clinical translation

Series keywords: Bioelectronics; Neural interfaces; Targeted neuromodulation; Closed-loop neuromodulation; Data analytics; Implantable devices; Animal models of disease; Translational medicine applications

This collection of articles has not been sponsored and articles have undergone the journal’s standard peer-review process.

You can submit to this series, here.

  1. Neuro-immune communication has gained enormous interest in recent years due to increasing knowledge of the way in which the brain coordinates functional alterations in inflammatory and autoimmune responses, an...

    Authors: Silvia V. Conde, Joana F. Sacramento and Fatima O. Martins

    Citation: Bioelectronic Medicine 2020 6:24

    Content type: Review

    Published on:

  2. Peripheral nerve reflexes enable organ systems to maintain long-term physiological homeostasis while responding to rapidly changing environmental conditions. Electrical nerve stimulation is commonly used to ac...

    Authors: Victoria Cotero, Tzu-Jen Kao, John Graf, Jeffrey Ashe, Christine Morton, Sangeeta S. Chavan, Stavros Zanos, Kevin J. Tracey and Christopher M. Puleo

    Citation: Bioelectronic Medicine 2020 6:21

    Content type: Research article

    Published on:

  3. Conventional neurostimulation systems for preclinical research can be bulky and invasive due to the need for batteries or wired interfaces. Emerging as a new neural interface technique, ultrasound-powered piez...

    Authors: Tao Sun, Jason Wright and Timir Datta-Chaudhuri

    Citation: Bioelectronic Medicine 2020 6:16

    Content type: Commentary

    Published on:

    The original article was published in Bioelectronic Medicine 2020 6:13

  4. Efficient identification of effective neurostimulation strategies is critical due to the growing number of clinical applications and the increasing complexity of the corresponding technology. In consequence, i...

    Authors: Marco Capogrosso and Scott F. Lempka

    Citation: Bioelectronic Medicine 2020 6:10

    Content type: Perspective

    Published on:

  5. Modulation of the nervous system by delivering electrical or pharmaceutical agents has contributed to the development of novel treatments to serious health disorders. Recent advances in multidisciplinary resea...

    Authors: Amparo Güemes Gonzalez, Ralph Etienne-Cummings and Pantelis Georgiou

    Citation: Bioelectronic Medicine 2020 6:11

    Content type: Mini-review

    Published on:

  6. Electrical stimulation of peripheral nerves is a widely used technique to treat a variety of conditions including chronic pain, motor impairment, headaches, and epilepsy. Nerve stimulation to achieve efficacio...

    Authors: Téa Tsaava, Timir Datta-Chaudhuri, Meghan E. Addorisio, Emily Battinelli Masi, Harold A. Silverman, Justin E. Newman, Gavin H. Imperato, Chad Bouton, Kevin J. Tracey, Sangeeta S. Chavan and Eric H. Chang

    Citation: Bioelectronic Medicine 2020 6:8

    Content type: Research article

    Published on:

    The original article was published in Bioelectronic Medicine 2020 6:12

  7. The recent opioid crisis is one of the rising challenges in the history of modern health care. New and effective treatment modalities with less adverse effects to alleviate and manage this modern epidemic are ...

    Authors: Imran S. Qureshi, Timir Datta-Chaudhuri, Kevin J. Tracey, Valentin A. Pavlov and Andrew C. H. Chen

    Citation: Bioelectronic Medicine 2020 6:7

    Content type: Mini-review

    Published on:

  8. Addictive disorders are a severe health concern. Conventional therapies have just moderate success and the probability of relapse after treatment remains high. Brain stimulation techniques, such as transcrania...

    Authors: Bettina Habelt, Mahnaz Arvaneh, Nadine Bernhardt and Ivan Minev

    Citation: Bioelectronic Medicine 2020 6:4

    Content type: Review

    Published on:

    The Correction to this article has been published in Bioelectronic Medicine 2020 6:6