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More than 100 years since the outbreak of the 1918 influenza pandemic, we now face another: COVID-19, which is caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Despite great worldwide efforts made in almost every country since its first report in December 2019, this disease continues to spread globally with 140 million cases and 3 million deaths so far. Here, we showcase interesting research from the journal on this disease.  These papers describe the distinct aspects of the virus on immunology, epidemiology, as well as its liaison with potential therapeutic interventions.

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  1. SARS-CoV-2 infection could cause severe acute respiratory syndrome, largely attributed to dysregulated immune activation and extensive lung tissue damage. However, the underlying mechanisms are not fully under...

    Authors: He Ren, Chaobing Ma, Haoran Peng, Bo Zhang, Lulin Zhou, Yan Su, Xiaoyan Gao and Hongyan Huang
    Citation: Biology Direct 2021 16:20
  2. Skeletal muscle has an extraordinary regenerative capacity reflecting the rapid activation and effective differentiation of muscle stem cells (MuSCs). In the course of muscle regeneration, MuSCs are reprogramm...

    Authors: Jiankai Fang, Chao Feng, Wangwang Chen, Pengbo Hou, Zhanhong Liu, Muqiu Zuo, Yuyi Han, Chenchang Xu, Gerry Melino, Alexei Verkhratsky, Ying Wang, Changshun Shao and Yufang Shi
    Citation: Biology Direct 2021 16:18
  3. The interaction between proteins is a fundamental event for cellular life that is generally mediated by specialized protein domains or modules. PDZ domains are the largest class of protein–protein interaction ...

    Authors: Caterina Nardella, Lorenzo Visconti, Francesca Malagrinò, Livia Pagano, Marianna Bufano, Marianna Nalli, Antonio Coluccia, Giuseppe La Regina, Romano Silvestri, Stefano Gianni and Angelo Toto
    Citation: Biology Direct 2021 16:15
  4. Knowing the “point of view” of the immune system is essential to understand the characteristic of a pandemic, such as that generated by the Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2, responsib...

    Authors: Ivana Celardo, Luigia Pace, Loredana Cifaldi, Carlo Gaudio and Vincenzo Barnaba
    Citation: Biology Direct 2020 15:30
  5. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection spreaded rapidly worldwide, as far as it has become a global pandemic. Therefore, the introduction of serological tests for determination ...

    Authors: Annalisa Noce, Maria Luisa Santoro, Giulia Marrone, Cartesio D’Agostini, Ivano Amelio, Andrea Duggento, Manfredi Tesauro and Nicola Di Daniele
    Citation: Biology Direct 2020 15:21