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The role of the ubiquitination-proteasome pathway in breast cancer

Nancy Hynes

  1. Aberrant activity of growth factor receptors has been implicated in the pathogenesis of a wide variety of malignancies. The negative regulation of signaling by growth factor receptors is mediated in large part...

    Authors: Stan Lipkowitz
    Citation: Breast Cancer Research 2002 5:8
  2. The ubiquitin-proteasome pathway is responsible for most eukaryotic intracellular protein degradation. This pathway has been validated as a target for antineoplastic therapy using both in vitro and preclinical mo...

    Authors: Robert Z Orlowski and E Claire Dees
    Citation: Breast Cancer Research 2002 5:1