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Tyrosine kinase signalling in breast cancer

Nancy Hynes

  1. The ability of growth factors and their cognate receptors to induce mammary epithelial proliferation and differentiation is dependent on their ability to activate a number of specific signal transduction pathw...

    Authors: Eran R Andrechek and William J Muller

    Citation: Breast Cancer Research 2000 2:211

    Content type: Review

    Published on:

  2. Both the non-receptor tyrosine kinase, c-Src, and members of the epidermal growth factor (EGF) receptor family are overexpressed in high percentages of human breast cancers. Because these molecules are plasma ...

    Authors: Jacqueline S Biscardi, Rumey C Ishizawar, Corinne M Silva and Sarah J Parsons

    Citation: Breast Cancer Research 2000 2:203

    Content type: Review

    Published on:

  3. The past decade has seen the definition of key signalling pathways downstream of receptor tyrosine kinases (RTKs) in terms of their components and the protein-protein interactions that facilitate signal transd...

    Authors: Rania Kairouz and Roger J Daly

    Citation: Breast Cancer Research 2000 2:197

    Content type: Review

    Published on:

  4. The fibroblast growth factors [Fgfs (murine), FGFs (human)] constitute a large family of ligands that signal through a class of cell-surface tyrosine kinase receptors. Fgf signalling has been associated in vitro ...

    Authors: Clive Dickson, Bradley Spencer-Dene, Christian Dillon and Vera Fantl

    Citation: Breast Cancer Research 2000 2:191

    Content type: Review

    Published on:

  5. Cross-communication between different signalling systems is critical for the integration of multiple and changing environmental influences on individual cells. The epidermal growth factor receptor (EGFR) has b...

    Authors: Norbert Prenzel, Esther Zwick, Michael Leserer and Axel Ullrich

    Citation: Breast Cancer Research 2000 2:184

    Content type: Review

    Published on: