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Seminal Plasma

An article collection published in Basic and Clinical Andrology.

Seminal plasma is a complex fluid comprised of secretions from all organs or tubules of the seminal tract (bulbourethral glands, seminal vesicles, prostate, vasa deferentia and epididymides) and from the seminiferous tubules in the testicles. 
Seminal plasma serves as a medium to carry, protect, and nourish spermatozoa after ejaculation up to fertilization, and as a functional modulator of spermatozoa function.  Moreover, seminal fluid contact at conception contributes to activating the endometrial gene expression and immune cell changes required for robust implantation, influencing not only the quality of the ensuing pregnancy but also the health of offspring.

Aim of the 'Seminal Plasma' series
Men are directly implicated in about 50% of couple infertility; however, in most cases of male infertility, the major treatment is female-oriented through Medically Assisted Reproductive Technologies (MART). It seems obvious that seminal plasma is still a black box to decipher. This article collection further explores the most recent research documenting the advancements in constitution, composition and functions of seminal plasma, the use of its components in the etiological diagnosis of male infertility, as well as its impacts on embryo’s implantation and ensuing pregnancy.

Submission is open to everyone, and all submitted manuscripts will be peer-reviewed through the regular journal review process. Manuscripts should be formatted according to the journal submission guidelines and submitted via the online submission system. In the submission system please ensure that the correct thematic series title is chosen from the additional information tab. Please also indicate clearly in the covering letter which thematic series you are submitting to.

If you have any research you would like us to consider for inclusion in our special collection, please submit directly to Basic and Clinical Andrology

Edited by: Roger Mieusset, MD, PhD
Guest Editor: Safouane Hamdi, PharmD, PhD

  1. Non-obstructive azoospermia (NOA) is considered to be the most severe form of male infertility. Before the emergence of surgical testicular sperm extraction and assisted reproductive technology, NOA patients c...

    Authors: Junjun Li, Fang Yang, Liang Dong, Degui Chang and Xujun Yu
    Citation: Basic and Clinical Andrology 2023 33:9
  2. Excess weight and metabolic disorders have a negative impact on male reproductive functions. The mechanisms involved are numerous and complex and epigenetic mechanisms may also be involved, notably through the...

    Authors: Sarah Saget, Laurent Kappeler, Valérie Grandjean, Patricia Leneuve, Isabelle Berthaut, Céline Faure, Sébastien Czernichow, Chrystèle Racine, Rachel Lévy and Charlotte Dupont
    Citation: Basic and Clinical Andrology 2022 32:9
  3. Extracellular Vesicles (EVs) are membrane-limited particles containing proteins, lipids, metabolites and nucleic acids that are secreted by healthy and cancerous cells. These vesicles are very heterogeneous in...

    Authors: Anne-Sophie Neyroud, Régina Chiechio, Marina Yefimova, Maria Josè Lo Faro, Nathalie Dejucq-Rainsford, Sylvie Jaillard, Pascale Even-Hernandez, Valérie Marchi and Célia Ravel
    Citation: Basic and Clinical Andrology 2021 31:25
  4. Sperm cryopreservation, an effective method for preserving male fertility, is very advantageous for men suffering from cancer. Unfortunately, as both physicians and cancer patients are unaware of the possibili...

    Authors: Xiao Liu, Bo Liu, Shasha Liu, Yang Xian, Wenrui Zhao, Bin Zhou, Xiao Xiao, Li Wang, Xiaofang Zhu, Bizhen Shu, Min Jiang and Fuping Li
    Citation: Basic and Clinical Andrology 2021 31:24
  5. In 1999, despite a longstanding use, the WHO manual for the examination of human semen finally proposed to assay several biochemical components of the seminal plasma for a functional exploration of the male ac...

    Authors: Safouane M. Hamdi, Erick Sanchez, Delphine Garimbay and Stéphanie Albarede
    Citation: Basic and Clinical Andrology 2020 30:18
  6. Only 2–5% of seminal fluid is composed of spermatozoa, while the rest is seminal plasma. The seminal plasma is a rich cocktail of organic and inorganic compounds including hormones, serving as a source of nutr...

    Authors: Jana Vitku, Lucie Kolatorova and Richard Hampl
    Citation: Basic and Clinical Andrology 2017 27:19
  7. More and more HIV-1-infected men on effective antiretroviral treatment (ART) have unprotected sex in order to procreate. The main factor influencing transmission is seminal HIV shedding. While the risk of HIV ...

    Authors: Christophe Pasquier, Marie Walschaerts, Stéphanie Raymond, Nathalie Moinard, Karine Saune, Myriam Daudin, Jacques Izopet and Louis Bujan
    Citation: Basic and Clinical Andrology 2017 27:17
  8. Semenogelins (SEMGs) are major components of human seminal vesicle secretions. Due to SEMG’s sperm-motility inhibitor, a significant negative correlation between sperm motility and the proportion of SEMG-bound...

    Authors: Kazumitsu Yamasaki, Kaoru Yoshida, Miki Yoshiike, Kazuhiko Shimada, Hiroyuki Nishiyama, Satoru Takamizawa, Kaoru Yanagida and Teruaki Iwamoto
    Citation: Basic and Clinical Andrology 2017 27:15