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Highlights in autophagy

This thematic series, published in Journal of Biomedical Science, highlights recent advances in the research field of autophagy. 

  1. Research

    Insulin receptor substrate-1 prevents autophagy-dependent cell death caused by oxidative stress in mouse NIH/3T3 cells

    Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen spe...

    Shih-Hung Chan, Ushio Kikkawa, Hidenori Matsuzaki, Jyh-Hong Chen and Wen-Chang Chang

    Journal of Biomedical Science 2012 19:64

    Published on: 12 July 2012

  2. Research

    Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila

    Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulatio...

    Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen and Horng-Dar Wang

    Journal of Biomedical Science 2012 19:52

    Published on: 23 May 2012