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Highlights in autophagy

This thematic series, published in Journal of Biomedical Science, highlights recent advances in the research field of autophagy. 

  1. Autophagy is a protein degradative process important for normal cellular metabolism. It is apparently used also by cells to eliminate invading pathogens. Interestingly, many pathogens have learned to subvert t...

    Authors: Sai-Wen Tang, Aurelie Ducroux, Kuan-Teh Jeang and Christine Neuveut
    Citation: Journal of Biomedical Science 2012 19:92
  2. Insulin receptor substrate (IRS)-1 is associated with tumorigenesis; its levels are elevated in several human cancers. IRS-1 protein binds to several oncogene proteins. Oxidative stress and reactive oxygen spe...

    Authors: Shih-Hung Chan, Ushio Kikkawa, Hidenori Matsuzaki, Jyh-Hong Chen and Wen-Chang Chang
    Citation: Journal of Biomedical Science 2012 19:64
  3. Autophagy and molecular chaperones both regulate protein homeostasis and maintain important physiological functions. Atg7 (autophagy-related gene 7) and Hsp27 (heat shock protein 27) are involved in the regulatio...

    Authors: Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang, Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen and Horng-Dar Wang
    Citation: Journal of Biomedical Science 2012 19:52
  4. Autophagy plays a significant role in myocardial ischemia-reperfusion (IR) injury. So it is important to inhibit autophagy to protect cardiomyocytes besides anti-apoptosis. MiRNA has been demonstrated to prote...

    Authors: Jian Xiao, Xiaoyan Zhu, Bin He, Yufeng Zhang, Bo Kang, Zhinong Wang and Xin Ni
    Citation: Journal of Biomedical Science 2011 18:35