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Advancing Respiratory Research and Pulmonary Medicine through Novel Technologies

Guest Editor: Dr. Xiaobo Zhou, Brigham and Women's Hospital

The field of respiratory research and pulmonary medicine has benefited and will continue to benefit from the development of novel technologies. This series of articles, published in Respiratory Research, provides comprehensive reviews on some of the most exciting and recent technological advances, ranging from new in vitro culture systems to extracellular nanovescicles and to CRISPR-based genome-editing tools. The articles will not only provide up-to-date review on these technologies but also will discuss how these technologies will specifically shape and advance respiratory research and pulmonary medicine. The articles aim to address the needs of basic researchers, clinicians and other individuals that need up-to-date information on technological innovations relevant to respiratory research.

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  1. The level of linked N-acetylglucosamine (O-GlcNAc) has been proved to be a sensor of cell state, but its relationship with hyperoxia-induced alveolar type 2 epithelial cells injure and bronchopulmonary dysplas...

    Authors: Yu Xuefei, Liu Dongyan, Li Tianming, Zheng Hejuan and Fu Jianhua
    Citation: Respiratory Research 2023 24:16
    Content type: Research Published on:

  2. Chronic obstructive pulmonary disease (COPD) is a common respiratory disease, whose pathogenetic complexity was strongly associated with aging/smoking and poorly understood.

    Authors: Qiqing Huang, Yuanyuan Wang, Lili Zhang, Wei Qian, Shaoran Shen, Jingshen Wang, Shuangshuang Wu, Wei Xu, Bo Chen, Mingyan Lin and Jianqing Wu
    Citation: Respiratory Research 2022 23:367
    Content type: Research Published on:

  3. Ventilatory power is a novel index which could reflect both ventilation efficiency and peripheral blood flow. However, its clinical value in pulmonary hypertension (PH) is rarely discussed. In the present stud...

    Authors: Xin Li, Yi Zhang, Qi Jin, Zhihui Zhao, Qing Zhao, Lu Yan, Anqi Duan, Zhihua Huang, Meixi Hu, Changming Xiong, Qin Luo and Zhihong Liu
    Citation: Respiratory Research 2022 23:285
    Content type: Research Published on:

  4. Respiratory diseases represent a global health burden. Because research on therapeutic strategies of airway diseases is essential, the technique of precision-cut lung slices (PCLS) has been developed and widel...

    Authors: Sarah Marie Nußbaum, Julia Krabbe, Svenja Böll, Aaron Babendreyer and Christian Martin
    Citation: Respiratory Research 2022 23:261
    Content type: Research Published on:

  5. Acute respiratory distress syndrome (ARDS) is a life-threatening disease caused by the induction of inflammatory cytokines and chemokines in the lungs. There is a dearth of drug applications that can be used t...

    Authors: Funda Terzi, Beste Demirci, İrfan Çınar, Mohammad Alhilal and Huseyin Serkan Erol
    Citation: Respiratory Research 2022 23:249
    Content type: Research Published on:

  6. Alpha-1 antitrypsin deficiency (AATD) is a genetic disorder most commonly secondary to a single mutation in the SERPINA1 gene (PI*Z) that causes misfolding and accumulation of alpha-1 antitrypsin (AAT) in hepa...

    Authors: Nazli Khodayari, Regina Oshins, Borna Mehrad, Jorge E. Lascano, Xiao Qiang, Jesse R. West, L. Shannon Holliday, Jungnam Lee, Gayle Wiesemann, Soroush Eydgahi and Mark Brantly
    Citation: Respiratory Research 2022 23:232
    Content type: Research Published on:

    The Correction to this article has been published in Respiratory Research 2023 24:266

  7. Bangladesh introduced the 10-valent pneumococcal conjugate vaccine (PCV10) for children aged < 1 year in March 2015. Previous vaccine effectiveness (VE) studies for pneumonia have used invasive pneumococcal di...

    Authors: William Checkley, Shakir Hossen, Eric D. McCollum, Farhan Pervaiz, Catherine H. Miele, Miguel A. Chavez, Lawrence H. Moulton, Nicole Simmons, Arunangshu D. Roy, Nabidul H. Chowdhury, Salahuddin Ahmed, Nazma Begum, Abdul Quaiyum, Mathuram Santosham and Abdullah H. Baqui
    Citation: Respiratory Research 2022 23:198
    Content type: Research Published on:

  8. Some COVID-19 patients experience dyspnea without objective impairment of pulmonary or cardiac function. This study determined diaphragm function and its central voluntary activation as a potential correlate w...

    Authors: Jens Spiesshoefer, Janina Friedrich, Binaya Regmi, Jonathan Geppert, Benedikt Jörn, Alexander Kersten, Alberto Giannoni, Matthias Boentert, Gernot Marx, Nikolaus Marx, Ayham Daher and Michael Dreher
    Citation: Respiratory Research 2022 23:187
    Content type: Correspondence Published on:

  9. Recent studies have demonstrated the important role of metabolomics in the pathogenesis of asthma. However, the role of lung metabolomics in childhood persistent wheezing (PW) or wheezing recurrence remains po...

    Authors: Lingfang Liang, Minfei Hu, Yuanling Chen, Lingke Liu, Lei Wu, Chengcheng Hang, Xiaofei Luo and Xuefeng Xu
    Citation: Respiratory Research 2022 23:161
    Content type: Research Published on:

  10. Currently, strategies for improving alpha1 antitrypsin deficiency (AATD) diagnosis are needed. Here we report the performance of a multinational multiplex-based genotyping test on dried blood spots and buccal ...

    Authors: José Luis Lopez-Campos, Lourdes Osaba, Karen Czischke, José R. Jardim, Mariano Fernandez Acquier, Abraham Ali, Hakan Günen, Noelia Rapun, Estrella Drobnic and Marc Miravitlles
    Citation: Respiratory Research 2022 23:152
    Content type: Research Published on:

  11. Quantitative computed tomography (QCT) analysis may serve as a tool for assessing the severity of coronavirus disease 2019 (COVID-19) and for monitoring its progress. The present study aimed to assess the as...

    Authors: Ying Su, Ze-song Qiu, Jun Chen, Min-jie Ju, Guo-guang Ma, Jin-wei He, Shen-ji Yu, Kai Liu, Fleming Y. M. Lure, Guo-wei Tu, Yu-yao Zhang and Zhe Luo
    Citation: Respiratory Research 2022 23:105
    Content type: Research Published on:

  12. Airway pressure release ventilation (APRV) is widely available on mechanical ventilators and has been proposed as an early intervention to prevent lung injury or as a rescue therapy in the management of refrac...

    Authors: Sonal Mistry, Anup Das, Sina Saffaran, Nadir Yehya, Timothy E. Scott, Marc Chikhani, John G. Laffey, Jonathan G. Hardman, Luigi Camporota and Declan G. Bates
    Citation: Respiratory Research 2022 23:101
    Content type: Research Published on:

  13. Chronic cough is prevalent in the clinic. The existing therapies are mostly limited to medical treatment, with poor curative effects and serious side effects. Studies have suggested that the right dorsolateral...

    Authors: Peijun Gui, Lin Wang, Liya Guo, Chunwei Wu, Bo Zhang, Chen Chen and Ying Xie
    Citation: Respiratory Research 2022 23:99
    Content type: Research Published on:

  14. High-resolution computed tomography (HRCT) is recommended diagnosing and monitoring connective tissue disease-associated interstitial lung disease (CTD-ILD). Quantitative computed tomography has the potential ...

    Authors: Ling Chen, Min Zhu, Haiyan Lu, Ting Yang, Wanjiang Li, Yali Zhang, Qibing Xie, Zhenlin Li, Huajing Wan and Fengming Luo
    Citation: Respiratory Research 2022 23:47
    Content type: Research Published on:

  15. Recent studies have demonstrated that airway basal stem cells (BCs) transplantation can ameliorate bleomycin-induced idiopathic pulmonary fibrosis (IPF) through lung regeneration promotion. However, BCs under ...

    Authors: Huanbin Liu, Shuna Liu, Jinjun Jiang, Yidi Zhang, Yulong Luo, Jingxin Zhao, Jian Xu, Yuan Xie, Weiping Liao, Wei Wang, Yichu Nie, Shiyue Li and Wenbin Deng
    Citation: Respiratory Research 2022 23:39
    Content type: Research Published on:

  16. Chronic obstructive pulmonary disease (COPD) is an age-related condition that has been associated with early telomere attrition; the clinical implications of telomere shortening in COPD are not well known. In ...

    Authors: Ana I. Hernández Cordero, Chen Xi Yang, Xuan Li, Stephen Milne, Virginia Chen, Zsuzsanna Hollander, Raymond Ng, Gerard J. Criner, Prescott G. Woodruff, Stephen C. Lazarus, John E. Connett, MeiLan K. Han, Fernando J. Martinez, Robert M. Reed, S. F. Paul Man, Janice M. Leung…
    Citation: Respiratory Research 2021 22:316
    Content type: Research Published on:

  17. The intention of this short primer is to raise your appetite for proper quantitative assessment of lung micro-structure. The method of choice for obtaining such data is stereology. Rooted in stochastic geometr...

    Authors: Matthias Ochs and Julia Schipke
    Citation: Respiratory Research 2021 22:305
    Content type: Review Published on:

    The Correction to this article has been published in Respiratory Research 2022 23:53

  18. Dysbiosis of the gut microbiome is involved in the pathogenesis of various diseases, but the contribution of gut microbes to the progression of chronic obstructive pulmonary disease (COPD) is still poorly unde...

    Authors: Naijian Li, Zhouli Dai, Zhang Wang, Zhishan Deng, Jiahuan Zhang, Jinding Pu, Weitao Cao, Tianhui Pan, Yumin Zhou, Zhaowei Yang, Jing Li, Bing Li and Pixin Ran
    Citation: Respiratory Research 2021 22:274
    Content type: Research Published on:

  19. In patients with chronic obstructive pulmonary disease (COPD), the maximum level of diaphragm excursion (DEmax) is correlated with dynamic lung hyperinflation and exercise tolerance. This study aimed to elucidate...

    Authors: Masashi Shiraishi, Yuji Higashimoto, Ryuji Sugiya, Hiroki Mizusawa, Yu Takeda, Shuhei Fujita, Osamu Nishiyama, Shintarou Kudo, Tamotsu Kimura, Yasutaka Chiba, Kanji Fukuda, Yuji Tohda and Hisako Matsumoto
    Citation: Respiratory Research 2021 22:271
    Content type: Research Published on:

  20. Clinical course of pleuroparenchymal fibroelastosis (PPFE) shows considerable variation among patients, but there is no established prognostic prediction model for PPFE.

    Authors: Yoshiaki Kinoshita, Takato Ikeda, Takuto Miyamura, Yusuke Ueda, Yuji Yoshida, Hisako Kushima, Masaki Fujita, Takashi Ogura, Kentaro Watanabe and Hiroshi Ishii
    Citation: Respiratory Research 2021 22:215
    Content type: Research Published on:

  21. In this study, we tested whether a combination of radiomic features extracted from baseline pre-immunotherapy computed tomography (CT) images and clinicopathological characteristics could be used as novel noni...

    Authors: Bin Yang, Li Zhou, Jing Zhong, Tangfeng Lv  , Ang Li, Lu Ma, Jian Zhong, Saisai Yin, Litang Huang, Changsheng Zhou, Xinyu Li, Ying Qian Ge, Xinwei Tao, Longjiang Zhang, Yong Son and Guangming Lu
    Citation: Respiratory Research 2021 22:189
    Content type: Research Published on:

  22. Whole lung tissue transcriptomic profiling studies in chronic obstructive pulmonary disease (COPD) have led to the identification of several genes associated with the severity of airflow limitation and/or the ...

    Authors: Xiuying Li, Guillaume Noell, Tracy Tabib, Alyssa D. Gregory, Humberto E. Trejo Bittar, Ravi Vats, Tomasz W. Kaminski, John Sembrat, Mark E. Snyder, Divay Chandra, Kong Chen, Chunbin Zou, Yingze Zhang, Prithu Sundd, John F. McDyer, Frank Sciurba…
    Citation: Respiratory Research 2021 22:100
    Content type: Research Published on:

  23. Pulmonary infections are associated with a brisk inflammatory reaction to bacterial surface components. Lipopolysaccharides (LPS) trigger macrophage activation and release of mitochondrial metabolites that con...

    Authors: Sebastián A. Riquelme and Alice Prince
    Citation: Respiratory Research 2020 21:326
    Content type: Review Published on: